Abstract: A hydrophobic topical skin composition is disclosed. The composition includes greater than 50% w/w of the composition of a continuous hydrophobic carrier, 5-24% w/w of one or more volatile silicone fluids, and 0.1 to 5% w/w of the composition of a plurality of taxane nanoparticles, wherein the mean particle size (number) of the taxane nanoparticles is from 0.1 microns to 1.5 microns, and wherein the taxane nanoparticles are crystalline nanoparticles or a combination of amorphous and crystalline nanoparticles.

Abstract: Disclosed are compositions and methods useful for enhancing the skin penetration of drug nanoparticles. The compositions can be hydrophobic and include a hydrophobic carrier, a volatile silicone fluid, and drug nanoparticles. Also disclosed are methods for inhibiting crystal growth of drug nanoparticles in an aqueous carrier or a hydrophobic carrier. Further, methods to topically treat psoriasis using compositions containing nanoparticles of paclitaxel or other taxanes are disclosed.

Abstract: A system for detecting a temperature of a railroad train wheel or bearing includes a thermal line scanner and a processor. The thermal line scanner is positioned to capture a plurality of thermal line scans of the wheel or bearing. The processor is configured to analyze each of the plurality of thermal line scans, identify a selected line of the plurality of thermal line scans, and calculate the temperature of the wheel or the bearing based on the selected line. Thus, the system and method disclosed herein reduce the acquired thermal data first to a single line for one or both of the wheel temperature and bearing temperature and then to single values.

Abstract: Disclosed are compositions and methods useful for enhancing the skin penetration of drug nanoparticles. The compositions can be hydrophobic and include a hydrophobic carrier, a volatile silicone fluid, and drug nanoparticles. Also disclosed are methods for inhibiting crystal growth of drug nanoparticles in an aqueous carrier or a hydrophobic carrier. Further, methods to topically treat psoriasis using compositions containing nanoparticles of paclitaxel or other taxanes are disclosed.

Abstract: A system for detecting a temperature of a railroad train wheel or bearing includes a thermal line scanner and a processor. The thermal line scanner is positioned to capture a plurality of thermal line scans of the wheel or bearing. The processor is configured to analyze each of the plurality of thermal line scans, identify a selected line of the plurality of thermal line scans, and calculate the temperature of the wheel or the bearing based on the selected line. Thus, the system and method disclosed herein reduce the acquired thermal data first to a single line for one or both of the wheel temperature and bearing temperature and then to single values.

Abstract: The invention relates to a heatable floor for livestock stalls comprising a plurality of hollow, right-angled plate elements whose hollow spaces are filled with a heat transfer fluid and can be heated by means of heating lines (11) running through the hollow spaces, wherein each plate element comprises one upper shell (1) having an inlet opening (5) and forming a standing surface for the livestock and one lower shell (7) supporting the upper shell (1), the shells being connected to one another liquid-tight at their edges and having means for suspending carriers and being supported on one another by supports (6, 9) that run through the hollow space.

Abstract: The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular Argyrin and derivatives thereof, preferably Argyrin A, for the treatment of proliferative diseases, such as cancer, as well as the derivatization of said macrocycles.

Abstract: The invention relates to a heatable floor for livestock stalls comprising a plurality of hollow, right-angled plate elements whose hollow spaces are filled with a heat transfer fluid and can be heated by means of heating lines (11) running through the hollow spaces, wherein each plate element comprises one upper shell (1) having an inlet opening (5) and forming a standing surface for the livestock and one lower shell (7) supporting the upper shell (1), the shells being connected to one another liquid-tight at their edges and having means for suspending carriers and being supported on one another by supports (6, 9) that run through the hollow space.

Abstract: This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.

Abstract: The invention provides methods and compositions for reductively deoxygenating an amide group at a C-3? position of a taxane molecule followed by subsequent intra-molecular acyl migration of an acyl group to the C-3? position.

Abstract: The present invention provides a system which uses a number of network nodes (2) which can communicate wire lessly with communications devices (3-8) coupled to the network. The network nodes are all connected to a network server (1) which can be used to provide additional services, such as Internet connection. The system uses at least a local short range radio connection for interconnecting the network nodes (2) to the communications device (3-8), thereby allowing the user of a communications device access to the network from anywhere within range of a suitable network node. This allows network nodes to be located throughout a building, such that a user can have access to the communications network at any location within the building.

Abstract: The present invention provides a call handling device for connecting a wireless communications device to a communications network and allows call control features to be implemented. This is achieved by transferring control information indicative the call control features available to the user via a wireless connection. The call control features selected by a user are then implemented by the call handling device, making the call control features available to the user. The present invention also allows control information to be sent to alternative communications devices. This is useful for example when a user assistant is using a portable handset or the like to make a telephone call. In this case with the key pad located on the handset it is typically difficult to push buttons as well as speak on the phone simultaneously.