Patents by Inventor Roland Franke

Roland Franke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DELIVERY OF DRUG NANOPARTICLES AND METHODS OF USE THEREOF
    Publication number: 20220331261
    Abstract: A hydrophobic topical skin composition is disclosed. The composition includes greater than 50% w/w of the composition of a continuous hydrophobic carrier, 5-24% w/w of one or more volatile silicone fluids, and 0.1 to 5% w/w of the composition of a plurality of taxane nanoparticles, wherein the mean particle size (number) of the taxane nanoparticles is from 0.1 microns to 1.5 microns, and wherein the taxane nanoparticles are crystalline nanoparticles or a combination of amorphous and crystalline nanoparticles.
    Type: Application
    Filed: March 17, 2022
    Publication date: October 20, 2022
    Inventors: Keith JOHNSON, Robert LATHROP, Meidong YANG, Holly MAULHARDT, Roland FRANKE
  • Delivery of drug nanoparticles and methods of use thereof
    Patent number: 11331278
    Abstract: A hydrophobic topical skin composition is disclosed. The composition includes greater than 50% w/w of the composition of a continuous hydrophobic carrier, 5-24% w/w of one or more volatile silicone fluids, and 0.1 to 5% w/w of the composition of a plurality of taxane nanoparticles, wherein the mean particle size (number) of the taxane nanoparticles is from 0.1 microns to 1.5 microns, and wherein the taxane nanoparticles are crystalline nanoparticles or a combination of amorphous and crystalline nanoparticles.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: May 17, 2022
    Assignee: DFB SORIA, LLC
    Inventors: Keith Johnson, Robert Lathrop, Meidong Yang, Holly Maulhardt, Roland Franke
  • DELIVERY OF DRUG NANOPARTICLES AND METHODS OF USE THEREOF
    Publication number: 20210106539
    Abstract: A hydrophobic topical skin composition is disclosed. The composition includes greater than 50% w/w of the composition of a continuous hydrophobic carrier, 5-24% w/w of one or more volatile silicone fluids, and 0.1 to 5% w/w of the composition of a plurality of taxane nanoparticles, wherein the mean particle size (number) of the taxane nanoparticles is from 0.1 microns to 1.5 microns, and wherein the taxane nanoparticles are crystalline nanoparticles or a combination of amorphous and crystalline nanoparticles.
    Type: Application
    Filed: December 4, 2020
    Publication date: April 15, 2021
    Applicant: DFB Soria, LLC
    Inventors: Keith JOHNSON, Robert LATHROP, Meidong YANG, Holly MAULHARDT, Roland FRANKE
  • Delivery of drug nanoparticles and methods of use thereof
    Patent number: 10918606
    Abstract: Disclosed are compositions and methods useful for enhancing the skin penetration of drug nanoparticles. The compositions can be hydrophobic and include a hydrophobic carrier, a volatile silicone fluid, and drug nanoparticles. Also disclosed are methods for inhibiting crystal growth of drug nanoparticles in an aqueous carrier or a hydrophobic carrier. Further, methods to topically treat psoriasis using compositions containing nanoparticles of paclitaxel or other taxanes are disclosed.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: February 16, 2021
    Assignee: DFB Soria, LLC
    Inventors: Keith Johnson, Robert Lathrop, Meidong Yang, Holly Maulhardt, Roland Franke
  • DELIVERY OF DRUG NANOPARTICLES AND METHODS OF USE THEREOF
    Publication number: 20200069600
    Abstract: Disclosed are compositions and methods useful for enhancing the skin penetration of drug nanoparticles. The compositions can be hydrophobic and include a hydrophobic carrier, a volatile silicone fluid, and drug nanoparticles. Also disclosed are methods for inhibiting crystal growth of drug nanoparticles in an aqueous carrier or a hydrophobic carrier. Further, methods to topically treat psoriasis using compositions containing nanoparticles of paclitaxel or other taxanes are disclosed.
    Type: Application
    Filed: September 11, 2019
    Publication date: March 5, 2020
    Applicant: DFB Soria, LLC
    Inventors: Keith JOHNSON, Robert LATHROP, Meidong YANG, Holly MAULHARDT, Roland FRANKE
  • Delivery of drug nanoparticles and methods of use thereof
    Patent number: 10449162
    Abstract: Disclosed are compositions and methods useful for enhancing the skin penetration of drug nanoparticles. The compositions can be hydrophobic and include a hydrophobic carrier, a volatile silicone fluid, and drug nanoparticles. Also disclosed are methods for inhibiting crystal growth of drug nanoparticles in an aqueous carrier or a hydrophobic carrier. Further, methods to topically treat psoriasis using compositions containing nanoparticles of paclitaxel or other taxanes are disclosed.
    Type: Grant
    Filed: February 19, 2018
    Date of Patent: October 22, 2019
    Assignee: DFB Soria LLC
    Inventors: Keith Johnson, Robert Lathrop, Meidong Yang, Holly Maulhardt, Roland Franke
  • DELIVERY OF DRUG NANOPARTICLES AND METHODS OF USE THEREOF
    Publication number: 20180177739
    Abstract: Disclosed are compositions and methods useful for enhancing the skin penetration of drug nanoparticles. The compositions can be hydrophobic and include a hydrophobic carrier, a volatile silicone fluid, and drug nanoparticles. Also disclosed are methods for inhibiting crystal growth of drug nanoparticles in an aqueous carrier or a hydrophobic carrier. Further, methods to topically treat psoriasis using compositions containing nanoparticles of paclitaxel or other taxanes are disclosed.
    Type: Application
    Filed: February 19, 2018
    Publication date: June 28, 2018
    Applicant: DFB Soria, LLC
    Inventors: Keith JOHNSON, Robert LATHROP, Meidong YANG, Holly MAULHARDT, Roland FRANKE
  • Purification of Taxanes and Taxane Mixtures Using Polyethyleneimine-Bonded Resins
    Publication number: 20080076936
    Abstract: This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.
    Type: Application
    Filed: June 18, 2007
    Publication date: March 27, 2008
    Inventors: James Johnson, T.G. Sambandam, Barry Hand, Christopher Howe, Roland Franke, Brian Bucher, John Juchum, Rex Gallagher, Marc Plante, Edward Desimone, Dong Yang
  • Conversion of taxane molecules
    Publication number: 20050234249
    Abstract: The invention provides methods and compositions for reductively deoxygenating an amide group at a C-3? position of a taxane molecule followed by subsequent intra-molecular acyl migration of an acyl group to the C-3? position.
    Type: Application
    Filed: April 5, 2003
    Publication date: October 20, 2005
    Inventors: James Johnson, Rex Gallagher, Roland Franke