Abstract: The present invention includes compounds of formula (I) and methods for its preparation and treatment of disorders with activated peroxisome preoliferator-activated receptor gamma (PPARG), particularly cancer.

Abstract: The present invention includes compounds of formula (I) and methods for its preparation and treatment of disorders with activated peroxisome preoliferator-activated receptor gamma (PPARG), particularly cancer.

Abstract: The present invention relates to compounds of formula (1) in which A, U and R1 are as defined herein, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant KRAS signaling, as a sole agent or in combination with other active ingredients.

Abstract: Protein-inhibitory substituted pyrrolopyridine derivatives of formula (I) in which X, Y, R1, R2, R3 and R4 are as defined herein, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients.

Abstract: A breathing aid for laryngotomoy tracheostomy patients includes a filter house made from plastics material, which is provided to receive a replaceable filter and which is made in one piece with a cover having perforations, the cover being provided to close the filter house via a flexible integral hinge strip. The breathing aid includes a hood applicable upon the cover and having a downwardly directed suction channel through which the inhaled air has to pass before it reaches the filter, the hood having a recess which by cooperation with the hinge strip guarantees the correct orientation of the hood and holds it in this position. The filter house can be secured to an adhesive foil which has rectangular or square shape and the filter house is so orientated in relation to the foil that the pivot axis of the hinge will be parallel to one of the sides of the foil.

Abstract: The invention is directed to a breathing valve for patients requiring humidication and filtration of breathing air inhaled via tracheostomas and tracheal tubes. The breathing valve includes a valve body, a filter removably placeable inside the valve body, a cup-shaped cap attached over the opening of the valve body and a disc-shaped membrane disposed in front of the filter in the path of the inspired air. The breathing valve is intended to be a complete system. The system can be easily disassembled and components can be replaced by the user as required and this applies especially to the filter.