Abstract: A hot-gas conducting component for a flow machine has a nickel-base wrought alloy as structural material and a hot gas-side lining made from the group of iron-chromium-aluminum-yttrium alloys and a flow machine having a component of this type.

Abstract: Protein replacement therapy for patients with hemophilia or other inherited protein deficiencies is often complicated by pathogenic antibody responses, including antibodies that neutralize the therapeutic protein or that predispose to potentially life-threatening anaphylactic reactions by formation of IgE. Using murine hemophilia B as a model, we have developed a prophylactic protocol against such responses that is non-invasive and does not include immune suppression or genetic manipulation of the patient's cells. Oral delivery of coagulation factor IX (F. IX) expressed in chloroplasts, bioencapsulated in plant cells, effectively blocked formation of inhibitory antibodies in protein replacement therapy. Inhibitor titers were mostly undetectable and up to 100-fold lower in treated mice when compared to controls. Moreover, this treatment eliminated fatal anaphylactic reactions that occurred after 4 to 6 exposures to intravenous F. IX protein. While only 20-25% of control animals survived after 6-8 F.

Abstract: A kit having a) a cleaning device, the cleaning device (1) including an elongated base member (2) formed of at least two wires (3) being twisted with each other, and a plurality of bristles (4) fixed between the twisted wires (3) and extending away from the twisted wires (3), whereby the bristles (4) are positioned in a cleaning section (5) at a first end (6) of the base member (2); wherein the bristles (4) consist of titanium or a titanium alloy; and b) a container having a composition including ethylene diaminotetraacetic acid (EDTA) is disclosed. A method for cleaning and/or debriding and/or conditioning a biological mineralized surface and/or a biological soft tissue surface and/or a dental implant is also disclosed. Additionally, there is disclosed a method for preventing and/or treating a condition in a patient in need of such treatment.

Abstract: A method for applying a protective layer resistant to high-temperature degradation by corrosion and erosion to a base metal, comprises: applying a MCrAlY-based bond layer to the base metal; coating, by overaluminizing with an Al diffusion layer, the bond layer; subjecting the Al diffusion layer (14) to abrasion treatment so that an outer build-up layer is removed from the Al diffusion layer; and applying a ceramic thermal barrier coating of yttria partially stabilized zirconia to the remaining Al diffusion layer. The ceramic thermal barrier coating is applied to the remaining Al diffusion layer by air plasma spraying. The applied bond layer is subjected to a polishing treatment before being overaluminized such that a surface roughness of Ra?2 ?m is produced at the bond layer.

Abstract: Protein replacement therapy for patients with hemophilia or other inherited protein deficiencies is often complicated by pathogenic antibody responses, including antibodies that neutralize the therapeutic protein or that predispose to potentially life-threatening anaphylactic reactions by formation of IgE. Using murine hemophilia B as a model, we have developed a prophylactic protocol against such responses that is non-invasive and does not include immune suppression or genetic manipulation of the patient's cells. Oral delivery of coagulation factor IX (F. IX) expressed in chloroplasts, bioencapsulated in plant cells, effectively blocked formation of inhibitory antibodies in protein replacement therapy. Inhibitor titers were mostly undetectable and up to 100-fold lower in treated mice when compared to controls. Moreover, this treatment eliminated fatal anaphylactic reactions that occurred after 4 to 6 exposures to intravenous F. IX protein. While only 20-25% of control animals survived after 6-8 F.

Abstract: The present invention relates to the field of cleaning and/or conditioning of biological and dental implant surfaces. More particularly, the invention relates to a kit comprising a) a cleaning device said cleaning device (1) comprising: an elongated base member (2) formed of at least two wires (3) being twisted with each other, and a plurality of bristles (4) fixed between said twisted wires (3) and extending away from said twisted wires (3), whereby said bristles (4) are positioned in a cleaning section (5) at a first end (6) of said base member (2) wherein said bristles (4) consist of titanium or a titanium alloy; and b) a container comprising a composition comprising ethylene diaminotetraacetic acid (EDTA). The kit may be used for the cleaning and/or debridement and/or conditioning of a biological or dental implant surface in order to e.g. improve implant attachment and facilitate wound healing.

Abstract: A The hot-gas conducting component for a flow machine has a nickel-base wrought alloy as structural material and a hot gas-side lining made from the group of iron-chromium-aluminum-yttrium alloys and a flow machine having a component of this type.

Abstract: A method for marking titanium dioxide pigment particles, as well as a method for identifying and verifying products via the marked titanium dioxide pigment particles contained in these products. The marker substance(s) is/are added during titanium dioxide production, preferably during surface treatment, drying or steam-milling. Particularly suitable as marker substances are the lanthanides, yttrium, zinc, molybdenum, tungsten, germanium, tin and scandium. The method is used to verify authentic product, to identify product forgeries (product piracy), to track distribution channels, or to identify the pigment used in order to counter unjustified complaints. It can be used in the product segments: fibres for textiles, papers for documents, pharmaceuticals, and also for plastics and coatings.

Abstract: A device for determining the optimal dimensions of the components of a knee endoprosthesis, including A) an angular element (7) having a first anterior plate (9) and a second distal plate (10) that is arranged at right-angle thereto; B) a first caliper (16) that is arranged on the second plate (10) in a manner that permits it to be displaced parallel to the central axis (19) and to be arrested, and which has a bearing surface (25), the bearing surface being essentially parallel to the first plate (9) and provided for resting against a tibial plateau (29) when a knee joint is bent; and, C) a second caliper (11) that is arranged in a manner that permits the second caliper to be displaced parallel to the longitudinal axis (8) of the first plate (9) and to be arrested, and which has a bearing surface (24), the bearing surface being essentially parallel to the inner side (23) of the second plate (10) and provided for resting against the tibial plateau (29) when the knee joint is straightened.

Abstract: A device for aligning a guide template used in resecting a distal femur in a one-compartment joint replacement. The device includes first and second support members (12;5), at least one rod-like transverse coupler (10;12), and a guide template (20). The support members each include a support surface (3;6) that is adjustable to lie in one plane (1) and designed to bear against one condyle (24;25) of a femur (21). The transverse coupler is arranged parallel to a transverse axis (2), which, in its end portion, is connected to the first support member (12) and is releasably connectable to the second support member (5). The transverse axis (2) extends parallel to a plane (1). The guide template (20) is displaceable parallel to the plane (1) relative to the second support member (5) and releasably lockable thereon.

Abstract: The device for determining the optimal dimensions of the components of a knee endoprosthesis is essentially comprised of: