Abstract: The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: An Ethernet switch and a switch microcontroller or CPU are integrated onto a system-on-a-chip (SoC). The Ethernet switch remains independently operating at full speed even though the remainder of the SoC is being reset or is otherwise nonoperational. The Ethernet switch is on a separated power and clock domain from the remainder of the integrated SoC. A warm reset signal is trapped by control microcontroller (MCU) to allow the switch CPU to isolate the Ethernet switch and save state. When the Ethernet switch is isolated and operating independently, the warm reset request is provided to the other entities on the integrated SoC. When warm reset is completed, the state is restored and the various DMA and flow settings redeveloped in the integrated SoC to allow return to normal operating condition.

Abstract: Utilizing the techniques disclosed herein, sensor data inaccuracies may be corrected such that calculated fill levels more accurately reflect the actual fill level of the item within an automatic replenishment device (ARD). For example, the ARD may include a sensor configured to collect the sensor data (e.g., a distance between the sensor and an item contained within the ARD). Sensor data associated with an item within the ARD may be received. A measurement offset value specific to the item may be identified. An estimated fill level of the item within the ARD may be calculated based at least in part on the distance measured between the sensor and the item and the measurement offset value specific to the item.

Abstract: The embodiments provide a surgical marking system for measuring and marking the location of various anatomical landmarks/bones on patient's skin before a surgical procedure. The system includes a shaft having a plurality of metallic markings and a radiographical pointer tip which is visible on fluoroscopic x-ray images. The shaft further includes a fluid reservoir for marking the location of an incision so that it is visible through fluoroscopic imaging technology and which provides a temporary marking agent that readily disappears after the surgical procedure has completed.