Patents by Inventor Roland K. Robins, deceased

Roland K. Robins, deceased has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Procedures for obtaining ribo-C-nucleosides
    Patent number: 5907036
    Abstract: Novel procedures for obtaining ribo-C-nucleosides, including especially 2-.beta.-D-ribofuranosylthiazole-4-carboxylamide (tiazofirin) and 2-.beta.-D-ribofuranosylselenazole-4-carboxylamide (sylenazofurin) and synthesis intermediates thereof. The novel procedures involve introducing a cyano group at the 1' position of a ribose, directly or indirectly converting the cyano group to HN.dbd.C--OR.sub.1 or thicarboxylamide wherein R.sub.1 is a lower alkyl, forming the group which substituted for the cyano group into a heterocyclic ring containing an ester, and converting the ester into an amide.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: May 25, 1999
    Assignee: ICN Pharmaceuticals, Inc.
    Inventors: Kandasamy Ramasamy, Arthur F Lewis, Roland K Robins, deceased, Natarajan Raju, Ramesh Bharadwaj, Vjera Pejanovic
  • 8-chloro camp and related camp compounds as antineoplastic agents
    Patent number: 5792752
    Abstract: Site 1- and site 2-selective derivatives of cAMP have been found to inhibit the growth of a variety of cancer and leukemic cells. The compounds have been found to have a synergistic effect in cancer and leukemic cell growth inhibition when a site 1-selective compound is used in combination with a site 2-selective compound.
    Type: Grant
    Filed: October 27, 1994
    Date of Patent: August 11, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Yoon Sang Cho-Chung, Roland K. Robins, deceased
  • Treatment of malignant tumors with 8-chloroadenosine 3',5'-cyclic monophasphate
    Patent number: 5763419
    Abstract: The compound 8-chloroadenosine 3',5'-cyclic phosphate and its pharmaceutically acceptable salts are used to treat malignant tumors in afflicted hosts.
    Type: Grant
    Filed: May 10, 1995
    Date of Patent: June 9, 1998
    Assignee: ICN Pharmaceuticals
    Inventors: Roland K. Robins, deceased, Yoon Sang Cho-Chung