Abstract: A method of producing a protein of interest (POI) by culturing a recombinant eukaryotic cell line comprising an expression construct comprising a regulatable promoter and a nucleic acid molecule encoding a POI under the transcriptional control of said promoter, comprising the steps a) cultivating the cell line with a basal carbon source repressing the promoter, b) cultivating the cell line with a limited amount of a supplemental carbon source de-repressing the promoter to induce production of the POI at a transcription rate of at least 15% as compared to the native pGAP promoter, and c) producing and recovering the POI; and further an isolated regulatable promoter and a respective expression system.

Abstract: The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.

Abstract: A holding element for a terminal connector, having at least one socket part and at least one plug part, wherein the plug part can be inserted or is inserted in a socket portion of the socket part. The holding element can be plugged or is plugged onto the plug part for detachably holding the plug part in the socket part. The holding element has a holding element body, holding arms having latching lugs that are directed inwards with respect to the holding element, holding arms having latching lugs that are directed outwards with respect to the holding element, and axially on both sides, has an uninterrupted, continuous edge on the end side. The holding arms each have a free end that is spring-elastically movable in the radial direction, and an end opposite thereof that is fixed to the holding element body.

Abstract: A connector, having a socket part and a plug part being insertable into a socket section of the socket part, wherein the plug part is provided with a retaining element for detachably retaining the plug part in the socket part, the retaining element having a retaining arm with at least one outwardly projecting engaging catch, a free end, and an end secured to the retaining element body and can be spring-elastically moved in the radial direction in relation to the plug part for blocking the engaging catch on a blocking surface or a blocking opening of the socket part and releasing it from same, and a locking device being provided for securing the blocking status of the plug part and socket part and for indicating an incorrect assembly thereof, the locking device cooperating with the retaining element, and being a radially insertable locking element that cooperates with the retaining element in the region of the retaining arm thereof.

Abstract: A device for mounting an object on an interior trim of a vehicle. The interior trim forms a depression for receiving the object and has a holder to fix the object in the depression. Advantageously, at least two oppositely arranged protrusions, which function as a first holder and which narrow a loading opening of the depression, are provided and arranged such that during the loading of the depression with the object to be mounted, the object can be inserted into the depression between the protrusions solely with its narrow side in front and is held or can be held in the depression, in particular on all sides, via a subsequent rotational movement about a longitudinal axis of the object.

Abstract: The invention relates to a method for producing a polymer by means of nitroxyl-controlled polymerisation. According to the invention, a mixture is initiated which contains at least one radically polymerisable monomer and additionally contains at least one initiator, at least one reactive agent that converts at least one portion of the alkoxyamine end groups produced during the radical polymerisation into a non-polymerisable group, and at least one additive that accelerates the hydroxyl-controlled polymerisation and/or the conversion of the alkoxyamine end groups into a non-polymerisable group.

Abstract: The present invention relates to a method for casting electronic components. The invention also relates to a curable compound that can be used as casting compound in the method. The casting compound contains at least one cross-linking component which is homogeneously distributed in the casting compound and can cross-link to at least two different cross-linked systems. A first of these networks has a higher cross-link density than a second cross-linked system, wherein the cross-linking to the first cross-linked system is triggered via an event other than the cross-linking to the second cross-linked system. During casting, the at least one cross-linking component of the casting compound is cured at least in part to the first cross-linked system in at least one first region spaced from the components and at least to the second cross-linked system in a second region enclosing and immediately surrounding the components.

Abstract: A connector for connecting at least one fluid line with another fluid line or a power unit. The connector includes a housing, a mating connector and an adapter sleeve. The adapter sleeve includes positive-locking elements that retain the adapter sleeve engaged with the housing. The adapter sleeve further includes latching arms releasably retaining the mating connector in the adapter sleeve.

Abstract: A line connector with two mutually separate flow paths for the connection of a pipe-in-pipe line. The line connector has an inner connecting element for connecting to an inner pipe of the pipe-in-pipe line, an outer connecting element for connecting to an outer pipe of the pipe-in-pipe line, a first attachment element for attachment of the first line to the inner pipe, and a second attachment element for attachment of the second line to the outer pipe. The inner connecting element and the first attachment element are integrally formed on a separate attachment part. The outer connecting element is integrally formed on a separate pipe adapter part. And, the second attachment element is integrally formed on a separate connecting sleeve. The connecting sleeve permits at both sides, in the unassembled state, being pushed over the outer pipe. The invention also relates to a line set including the line connector.

Abstract: A plug-in connector assembly for connecting at least one fluid line to another fluid line or to an aggregate connection. The plug-in connector assembly includes, a housing, a mating plug-in connector and an adapter sleeve. The mating plug-in connector and the adapter sleeve are received within a sleeve section of the housing, with the adapter sleeve operating to attach the mating plug-in connector to the housing in a releasable manner.

Abstract: A device for mounting an object on an interior trim of a vehicle. The interior trim forms a depression for receiving the object and has a holder to fix the object in the depression. Advantageously, at least two oppositely arranged protrusions, which function as a first holder and which narrow a loading opening of the depression, are provided and arranged such that during the loading of the depression with the object to be mounted, the object can be inserted into the depression between the protrusions solely with its narrow side in front and is held or can be held in the depression, in particular on all sides, via a subsequent rotational movement about a longitudinal axis of the object.

Abstract: The present invention relates to a method for casting electronic components. The invention also relates to a curable compound that can be used as casting compound in the method. The casting compound contains at least one cross-linking component which is homogeneously distributed in the casting compound and can cross-link to at least two different cross-linked systems. A first of these networks has a higher cross-link density than a second cross-linked system, wherein the cross-linking to the first cross-linked system is triggered via an event other than the cross-linking to the second cross-linked system. During casting, the at least one cross-linking component of the casting compound is cured at least in part to the first cross-linked system in at least one first region spaced from the components and at least to the second cross-linked system in a second region enclosing and immediately surrounding the components.

Abstract: The invention relates to a method for producing a polymer by means of nitroxyl-controlled polymerisation. According to the invention, a mixture is initiated which contains at least one radically polymerisable monomer and additionally contains at least one initiator, at least one reactive agent that converts at least one portion of the alkoxyamine end groups produced during the radical polymerisation into a non-polymerisable group, and at least one additive that accelerates the hydroxyl-controlled polymerisation and/or the conversion of the alkoxyamine end groups into a non-polymerisable group.

Abstract: A holding element for a terminal connector, having at least one socket part and at least one plug part, wherein the plug part can be inserted or is inserted in a socket portion of the socket part. The holding element can be plugged or is plugged onto the plug part for detachably holding the plug part in the socket part. The holding element has a holding element body, holding arms having latching lugs that are directed inwards with respect to the holding element, holding arms having latching lugs that are directed outwards with respect to the holding element, and axially on both sides, has an uninterrupted, continuous edge on the end side. The holding arms each have a free end that is spring-elastically movable in the radial direction, and an end opposite thereof that is fixed to the holding element body.

Abstract: A connector, having a socket part and a plug part being insertable into a socket section of the socket part, wherein the plug part is provided with a retaining element for detachably retaining the plug part in the socket part, the retaining element having a retaining arm with at least one outwardly projecting engaging catch, a free end, and an end secured to the retaining element body and can be spring-elastically moved in the radial direction in relation to the plug part for blocking the engaging catch on a blocking surface or a blocking opening of the socket part and releasing it from same, and a locking device being provided for securing the blocking status of the plug part and socket part and for indicating an incorrect assembly thereof, the locking device cooperating with the retaining element, and being a radially insertable locking element that cooperates with the retaining element in the region of the retaining arm thereof

Abstract: A line connector for a urea-water solution in an SCR catalytic converter system. The line connector has two mutually separate flow paths for two fluid media, one for a functional medium and another for a temperature control medium for controlling the temperature of the functional medium. The line connector includes a connector body having a first connection for a first line conducting a functional medium, a second connection conducting a temperature control medium, and a third connection for a double line having an inner line and a coaxial outer line. The third connection has an inner connecting element with an inner passage and an outer connecting element with an outer passage. The connector body is formed in its interior such that the first and second connections merge separately from one another into the inner and outer passages, respectively, of the third connection.

Abstract: A plug-in connector assembly for connecting at least one fluid line to another fluid line or to an aggregate connection. The plug-in connector assembly includes, a housing, a mating plug-in connector and an adapter sleeve. The mating plug-in connector and the adapter sleeve are received within a sleeve section of the housing, with the adapter sleeve operating to attach the mating plug-in connector to the housing in a releasable manner.

Abstract: A connector for connecting at least one fluid line with another fluid line or a power unit. The connector includes a housing, a mating connector and an adapter sleeve. The adapter sleeve includes positive-locking elements that retain the adapter sleeve engaged with the housing. The adapter sleeve further includes latching arms releasably retaining the mating connector in the adapter sleeve.

Abstract: The present invention relates to a fiber reinforced composite comprising a reinforcing constituent of fibers embedded in a resin matrix, wherein the resin matrix comprises epoxy resin crosslinked with aminated lignin. The invention further relates to a method for the production of a fiber reinforced composite.

Abstract: The present invention related to a fiber mat reinforced resin composite comprising a reinforcing constituent of fibers in the form of at least one mat embedded within a resin matrix. The invention further relates to a method for the production of a fiber mat reinforced resin composite.