Abstract: Methods, systems, apparatus, and computer programs, detecting behavioral anomalies in treatment adherence patterns.

Abstract: Methods, systems, and computer programs for predicting an entity's adherence or non-adherence to a regimen. A method includes accessing observed attributes of an entity during a first time duration, accessing historical data describing attributes of another entity, where the historical data was previously obtained during respective second time durations, for each of the other entities, that are each equal in duration to the first time duration, filtering the historical data to only include historical data describing attributes of at least one other entity that satisfy a similarity threshold, the similarity threshold defining a relationship between the observed attributes and the historical data based on a distorted distance measure, collapsing the remaining historical data into one or more representative data, and for each representative data series, generating a similarity based prediction related to an outcome for the entity based on (i) the observed data and (ii) the representative data attributes.

Abstract: The present invention concerns heterobicyclic compounds of formula (I) processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

Abstract: A loose wheel restraint safety system provides bolt-on support brackets in a system for attachment to the chassis or to the body of a vehicle, to which brackets wheel restraint bars are detachably mounted. The brackets of the system are located adjacent the wheels of the vehicle, such that the restraint bars, when mounted, are located in close proximity to the tires and extend horizontally across the wheel. The system elements, when bolted in place form, in combination with the adjoining vehicle bed or chassis portions, substantial wheel enclosures that permit each wheel and rim to turn freely upon its axle or spindle, while restraining the wheel against lateral deviation from its axle. The system is applied to each outer wheel of a multi-wheel rig, to restrain a break-away wheel against run-away, such that the driver, upon observing the situation, can pull the rig off the road and to a halt.