Patents by Inventor Roland Knoblauch

Roland Knoblauch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dosing Regimen for Therapies Comprising Bispecific Anti-EGFR/C-Met Antibodies
    Publication number: 20240109969
    Abstract: Provided are methods of treating an epidermal growth factor receptor (EGFR)-expressing or hepatocyte growth factor receptor (c-Met)-expressing cancer in a subject in need thereof. The methods comprise administering to the subject a therapy comprising an isolated bispecific anti-EGFR/c-Met antibody, wherein the administration comprises a dose of about 1400-2100 mg, administered once per a 21-day cycle.
    Type: Application
    Filed: July 14, 2023
    Publication date: April 4, 2024
    Inventor: Roland Knoblauch
  • High Concentration Bispecific Antibody Formulations
    Publication number: 20240034813
    Abstract: Provided herein are stable aqueous pharmaceutical compositions comprising high concentration formulations of a bispecific epidermal growth factor receptor (EGFR)/hepatocyte growth factor receptor (c-Met) antibody and methods of preparing the same. Also provided herein are methods of treating cancer in a subject in need thereof by subcutaneously administering to the subject the stable aqueous pharmaceutical compositions as disclosed herein.
    Type: Application
    Filed: May 24, 2023
    Publication date: February 1, 2024
    Inventors: Roland Knoblauch, Satyen Torne
  • Use of Amivantamab to Treat Colorectal Cancer
    Publication number: 20230183360
    Abstract: The present invention relates to methods of treating colorectal cancer (CRC), such as metastatic colorectal cancer (mCRC), in a subject in need thereof, comprising administering a therapeutically effective amount of an antibody (e.g., a bispecific antibody) to the subject, wherein the antibody specifically binds epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (c-Met).
    Type: Application
    Filed: December 8, 2022
    Publication date: June 15, 2023
    Inventor: Roland Knoblauch
  • Use of Approved Bispecific EGFR and Met Specific Antibody Drug Product to Treat Non-Small Cell Lung Cancer (NSCLCL)
    Publication number: 20230174677
    Abstract: The present invention relates to methods of treating lung cancer using an approved drug product comprising amivantamab. Also described are drug products containing amivantamab, and methods of selling or offering for sale a drug product comprising amivantamab.
    Type: Application
    Filed: November 16, 2022
    Publication date: June 8, 2023
    Inventor: Roland Knoblauch
  • High Concentration Bispecific Antibody Formulations
    Publication number: 20220395573
    Abstract: Provided herein are stable aqueous pharmaceutical compositions comprising high concentration formulations of a bispecific epidermal growth factor receptor (EGFR)/hepatocyte growth factor receptor (c-Met) antibody and methods of preparing the same. Also provided herein are methods of treating cancer in a subject in need thereof by subcutaneously administering to the subject the stable aqueous pharmaceutical compositions as disclosed herein.
    Type: Application
    Filed: April 21, 2022
    Publication date: December 15, 2022
    Inventors: Roland Knoblauch, Satyen Torne
  • Treatment of Non-Small Cell Lung Cancer with EGFR Mutations
    Publication number: 20220064306
    Abstract: The present invention relates to treatment of subjects having EGFR exon 20 insertion and other uncommon EGFR mutations.
    Type: Application
    Filed: August 25, 2021
    Publication date: March 3, 2022
    Inventors: Roland Knoblauch, Sheri Moores
  • Treatment of Patients Having c-Met Exon 14 Skipping Mutations
    Publication number: 20210253717
    Abstract: The present invention relates to treatment of subjects having a cancer that is positive for c-Met exon 14 skipping mutations.
    Type: Application
    Filed: February 12, 2021
    Publication date: August 19, 2021
    Inventors: Roland Knoblauch, Sylvie Laquerre, Sheri Moores
  • Methods of treating cancer with phenformin
    Patent number: 8574829
    Abstract: Methods of using phenformin to treat certain types of cancers are described.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: November 5, 2013
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Craig B. Thompson, Roland Knoblauch
  • METHODS OF TREATING CANCER WITH PHENFORMIN
    Publication number: 20120114676
    Abstract: Methods of using phenformin to treat certain types of cancers are described.
    Type: Application
    Filed: March 30, 2010
    Publication date: May 10, 2012
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Craig B. Thompson, Roland Knoblauch