Abstract: The present invention provides an immunotherapeutic composition for use in combination with one or more MDSC (Myeloid-derived suppressor cells) modulator(s) and a kit of parts comprising such components as well as methods using such components in combination. The invention also provides the use of Phosphodiesterase-5 (PDE5) inhibitors for reversing immunosuppression in chronic infectious diseases. The invention is of very special interest in treating or preventing diseases, especially chronic infectious diseases such as hepatitis B.

Abstract: The present invention generally relates to an immunostimulatory combination comprising a first composition comprising a therapeutic vaccine and a second composition comprising one or more TLR9 ligand(s) such as CpG-containing oligonucleotide(s) as well as the use of such a first composition in combination with said second composition for treating a subject in need thereof. A specific embodiment is directed to the combination of a vectorized therapeutic vaccine encoding antigen(s) and a CpG-containing oligonucleotide such as Litenimod. Embodiments also include kits comprising such compositions as well as methods for treating, preventing or inhibiting diseases, in particular proliferative diseases or infectious diseases comprising administration of such first and second compositions.

Abstract: The invention is related to fusion proteins comprising two or more IgG binding domains of streptococcal protein G, linked to a polypeptide of interest. These fusion proteins can be complexed with IgG antibodies directed against surface receptors of target cells, allowing their delivery to said target cells.

Abstract: The present invention relates to a process for preparing a catalyst solid for olefin polymerization which is obtainable by bringing A) at least one organic transition metal compound, B) at least one organometallic compound, C) at least one organic compound having at least one functional group containing active hydrogen, D) at least one Lewis base and E) at least one support, into contact with one another, wherein the components are combined in any order without any work-up of the mixtures present at intermediate stages being carried out. In addition, the invention relates to the use of the catalyst solid for olefin polymerization, to catalyst solids obtainable by this process, to catalyst systems in which these catalyst solids are present and to a process for the polymerization of olefins in which these catalyst solids are used.

Abstract: A process for the polymerization of olefins, in particular a process for the copolymerization of propylene with further olefins, is carried out in the presence of highly active catalyst systems comprising specifically selected metallocenes, in particular ones which bear different substituents in position 2 and position 4 on an indenyl ligand. Novel polypropylene copolymers can be obtained by this process.

Abstract: The present invention relates to a process for preparing a supported cocatalyst for olefin polymerization, which comprises reacting A) a support bearing functional groups, B) triethylaluminum and C) a compound of the formula (I), (R1)x—A—OH)y??(I) where A is an atom of group 13 or 15 of the Periodic Table, R1 are identical or different and are each, independently of one another, hydrogen, halogen, C1-C20-alkyl, C1-C20-haloalkyl, C1-C10-alkoxy, C6-C20-aryl, C6-C20-haloaryl, C6-C20-aryloxy, C7-C40-arylalky, C7-C40-haloarylalkyl, C7-C40-alkylaryl, C7-C40-haloalkylaryl or an OSiR32 group, where R2 are identical or different and are each hydrogen, halogen, C1-C20-alkyl, C1-C20-haloalkyl, C1-C10-alkoxy, C6-C20-aryl, C6-C20-haloaryl, C6-C20-aryloxy, C7-C40-arylalkyl, C7-C40-haloarylalkyl, C7-C40-alkylaryl or C7-C40-haloalkylaryl, y is 1 or 2 and x is 3 minus y.

Abstract: The present invention relates to a process for preparing a catalyst composition for olefin polymerization, which comprises preparing a catalyst solid in a first step by bringing A) at least one support, B) at least one organic compound having at least one functional group containing active hydrogen, C) at least one organometallic compound and D) at least one organic transition metal compound into contact with one another, then bringing this catalyst solid into contact with E) at least one organoaluminum compound in a second step and then using this mixture for the polymerization without further work-up. In addition, the invention relates to catalyst system for the polymerization of olefins which comprise such catalyst compositions, to the use of the catalyst compositions or the catalyst systems for the polymerization of olefins and to a process of the polymerization of olefins.

Abstract: A process for the polymerization of olefins, in particular a process for the copolymerization of propylene with further olefins, is carried out in the presence of highly active catalyst systems comprising specifically selected metallocenes, in particular ones which bear different substituents in position 2 and position 4 on an indenyl ligand. Novel polypropylene copolymers can be obtained by this process.

Abstract: The present invention relates to a process for preparing a catalyst for olefin polymerization which is obtainable by bringing A) at least one organic transition metal compound, B) a mixture of at least two different organo metallic compounds and C) at least one cation-forming compound into contact with one another, wherein the organic transition metal compound A) is firstly brought into contact with the mixture of the organo metallic compounds B). In addition, the invention relates to the use of the catalyst for olefin polymerization, to catalysts obtainable by this process and to a process for the polymerization of olefins in which these catalysts are used.

Abstract: The present invention relates to a process for preparing a supported cocatalyst for olefin polymerization, which comprises reacting A) a support bearing functional groups, B) triethylaluminum and C) a compound of the formula (I), (R1)x—A—OH)y??(I) where A is an atom of group 13 or 15 of the Periodic Table, R1 are identical or different and are each, independently of one another, hydrogen, halogen, C1-C20-alkyl, C1-C20-haloalkyl, C1-C10-alkoxy, C6-C20-aryl, C6-C20-haloaryl, C6-C20-aryloxy, C7-C40-arylalky, C7-C40-haloarylalkyl, C7-C40-alkylaryl, C7-C40-haloalkylaryl or an OSiR32 group, where R2 are identical or different and are each hydrogen, halogen, C1-C20-alkyl, C1-C20-haloalkyl, C1-C10-alkoxy, C6-C20-aryl, C6-C20-haloaryl, C6-C20-aryloxy, C7-C40-arylalkyl, C7-C40-haloarylalkyl, C7-C40-alkylaryl or C7-C40-haloalkylaryl, y is 1 or 2 and x is 3 minus y.

Abstract: The present invention relates to a process for preparing a catalyst solid for olefin polymerization which is obtainable by bringing A) at least one organic transition metal compound, B) at least one organometallic compound, C) at least one organic compound having at least one functional group containing active hydrogen, D) at least one Lewis base and E) at least one support, into contact with one another, wherein the components are combined in any order without any work-up of the mixtures present at intermediate stages being carried out. In addition, the invention relates to the use of the catalyst solid for olefin polymerization, to catalyst solids obtainable by this process, to catalyst systems in which these catalyst solids are present and to a process for the polymerization of olefins in which these catalyst solids are used.

Abstract: The present invention relates to a process for preparing a catalyst composition for olefin polymerization, which comprises preparing a catalyst solid in a first step by bringing A) at least one support, B) at least one organic compound having at least one functional group containing active hydrogen, C) at least one organometallic compound and D) at least one organic transition metal compound into contact with one another, then bringing this catalyst solid into contact with E) at least one organoaluminum compound in a second step and then using this mixture for the polymerization without further work-up. In addition, the invention relates to catalyst system for the polymerization of olefins which comprise such catalyst compositions, to the use of the catalyst compositions or the catalyst systems for the polymerization of olefins and to a process of the polymerization of olefins.

Abstract: A process for the polymerization of olefins, in particular a process for the copolymerization of propylene with further olefins, is carried out in the presence of highly active catalyst systems comprising specifically selected metallocenes, in particular ones which bear different substituents in position 2 position 4 on an indenyl ligand. Novel polypropylene copolymers can be obtained by this process.

Abstract: The present invention relates to a process for preparing a catalyst for olefin polymerization which is obtainable by bringing A) at least one organic transition metal compound, B) a mixture of at least two different organo metallic compounds and C) at least one cation-forming compound into contact with one another, wherein the organic transition metal compound A) is firstly brought into contact with the mixture of the organo metallic compounds B). In addition, the invention relates to the use of the catalyst for olefin polymerization, to catalysts obtainable by this process and to a process for the polymerization of olefins in which these catalysts are used.

Abstract: A catalyst system comprising at least one metallocene, at least one cocatalyst, at least one support material and, if desired, further organometallic compounds is described. The catalyst system can advantageously be used for the polymerization of olefins and displays a high catalyst activity and gives a good polymer morphology without it being necessary to use aluminoxanes such as methylaluminoxane (MAO), which usually has to be used in high excess, as cocatalyst.

Abstract: A catalyst solid comprising: A) support particles having a mean particle diameter d50 of from 5 to 200 ?m and a specific surface area of from 30 to 1 000 m2/g and obtainable by agglomeration of primary particles of a pyrogenic silica having a mean particle diameter dm of from 1 to 50 nm, and B) at least one organic transition metal compound, can be used for the polymerization or copolymerization of olefins.

Abstract: Ligand systems containing indenyl structures, transition metal compounds of the metallocene type and catalyst systems comprising such transition metal compounds are described. The novel transition metal compounds can be used in the polymerization of olefins, in particular to give polyolefins having a low molar mass.

Abstract: A process for the polymerization of olefins, in particular a process for the copolymerization of propylene with further olefins, is carried out in the presence of highly active catalyst systems comprising specifically selected metallocenes, in particular ones which bear different substituents in position 2 and position 4 on an indenyl ligand. Novel polypropylene copolymers can be obtained by this process.

Abstract: The invention relates to a catalyst system, containing at least one metallocene, at least one co-catalyst, at least one supporting material and optionally additional organometallic compounds. The catalyst system can be used advantageously for polymerising olefins, as it obviates the use of aluminoxanes, such as methylaluminoxane (MAO), which is conventionally used in excess quantities as a co-catalyst, whilst at the same time producing strong catalyst activity and excellent polymer morphology.

Abstract: A boron-containing zwitterionic neutral transition metal compound which can advantageously be used for the polymerization of olefins is described. Here, the use of aluminoxanes, such as methylaluminoxane (MAO), as a cocatalyst can be dispensed with and a high catalyst activity and a good polymer morphology can nevertheless be achieved.