Patents by Inventor Roland Lauster

Roland Lauster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preparing an artificial tooth primordium in vitro and artificial tooth primordium derived therefrom
    Patent number: 11578308
    Abstract: The present invention is directed to a method of preparing an artificial tooth primordium in vitro, comprising the steps: a) providing isolated mesenchymal dental pulp cells; and b) culturing the mesenchymal dental pulp cells under non-adherent conditions to form a cell aggregate representing an artificial tooth primordium; as well as to an artificial tooth primordium derived therefrom.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: February 14, 2023
    Assignee: TECHNISCHE UNIVERSITAET BERLIN
    Inventors: Roland Lauster, Uwe Marx, Jennifer Binder, Mark Rosowski
  • METHOD OF PREPARING AN ARTIFICIAL TOOTH PRIMORDIUM IN VITRO AND ARTIFICIAL TOOTH PRIMORDIUM DERIVED THEREFROM
    Publication number: 20190185815
    Abstract: The present invention is directed to a method of preparing an artificial tooth primordium in vitro, comprising the steps: a) providing isolated mesenchymal dental pulp cells; and b) culturing the mesenchymal dental pulp cells under non-adherent conditions to form a cell aggregate representing an artificial tooth primordium; as well as to an artificial tooth primordium derived therefrom.
    Type: Application
    Filed: January 18, 2019
    Publication date: June 20, 2019
    Inventors: Roland LAUSTER, Uwe MARX, Jennifer BINDER, Mark ROSOWSKI
  • 3D in vitro bi-phasic cartilage-bone construct
    Patent number: 9856458
    Abstract: A 3D in vitro bi-phasic cartilage-bone organoid includes a layer of an artificial cartilage tissue, and a layer of an artificial bone tissue comprising a structure-giving scaffold and a bone marrow structure. The layer of the artificial cartilage tissue contacts at least one surface of the layer of the artificial bone tissue.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: January 2, 2018
    Assignee: TISSUSE GMBH
    Inventors: Mark Rosowski, Shirin Kadler, Roland Lauster, Uwe Marx
  • Methods for producing hair microfollicles and papillae and their use for in vitro tests and in vivo implantations
    Patent number: 9764064
    Abstract: The present invention relates to a method for producing hair microfollicles comprising the steps of: a) providing de novo papillae, b) providing other cell populations selected from the group of fibroblasts, keratinocytes and melanocytes, and co-culturing the de novo papillae with at least one other cell population in non-adherent culture vessels. The present invention relates also to methods of producing de novo papillae usable in said method for producing hair microfollicles.
    Type: Grant
    Filed: August 26, 2014
    Date of Patent: September 19, 2017
    Assignee: TECHNISCHE UNIVERSITAT BERLIN
    Inventors: Gerd Lindner, Roland Lauster
  • Circulation system
    Patent number: 9506024
    Abstract: A self-contained circulation system, which supports the formation of capillaries in capillary growth sections and allows the formation of micro organoids and/or micro tissue sections for monitoring the effect of one or more test compounds and determining efficacy, side-effects, biosafety, metabolites, mode of action or organ regeneration as well as methods of establishing such micro organoids and/or micro tissue in the self-contained circulation system.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: November 29, 2016
    Assignee: TISSUSE GMBH
    Inventors: Uwe Marx, Gerd Lindner, Reyk Horland, Silke Hoffmann, Roland Lauster
  • 3D IN VITRO BI-PHASIC CARTILAGE-BONE CONSTRUCT
    Publication number: 20150093428
    Abstract: A 3D in vitro bi-phasic cartilage-bone organoid includes a layer of an artificial cartilage tissue, and a layer of an artificial bone tissue comprising a structure-giving scaffold and a bone marrow structure. The layer of the artificial cartilage tissue contacts at least one surface of the layer of the artificial bone tissue.
    Type: Application
    Filed: February 28, 2013
    Publication date: April 2, 2015
    Applicant: TISSUSE GMBH
    Inventors: Mark Rosowski, Shirin Fatehi-Varkani, Roland Lauster, Uwe Marx
  • METHOD OF PREPARING AN ARTIFICIAL TOOTH PRIMORDIUM IN VITRO AND ARTIFICIALTOOTH PRIMORDIUM DERIVED THEREFROM
    Publication number: 20140377233
    Abstract: The present invention is directed to a method of preparing an artificial tooth primordium in vitro, comprising the steps: a) providing isolated mesenchymal dental pulp cells; and b) culturing the mesenchymal dental pulp cells under non-adherent conditions to form a cell aggregate representing an artificial tooth primordium; as well as to an artificial tooth primordium derived therefrom.
    Type: Application
    Filed: February 20, 2013
    Publication date: December 25, 2014
    Inventors: Roland Lauster, Uwe Marx, Jennifer Binder, Mark Rosowski
  • Methods for Producing Hair Microfollicles and De Novo Papillae and Their Use for In Vitro Tests and In Vivo Implantations
    Publication number: 20140370070
    Abstract: The present invention relates to a method for producing hair microfollicles comprising the steps of: a) providing de novo papillae, b) providing other cell populations selected from the group of fibroblasts, keratinocytes and melanocytes, and co-culturing the de novo papillae with at least one other cell population in non-adherent culture vessels. The present invention relates also to methods of producing de novo papillae usable in said method for producing hair microfollicles.
    Type: Application
    Filed: August 26, 2014
    Publication date: December 18, 2014
    Inventors: Gerd LINDNER, Roland LAUSTER
  • Methods for producing hair microfollicles and papillae and their use for in vitro tests and in vivo implantations
    Patent number: 8841124
    Abstract: The present invention relates to a method for producing hair microfollicles comprising the steps of: a) providing de novopapillae, b) providing other cell populations selected from the group of fibroblasts, keratinocytes and melanocytes, and co-culturing the de novopapillae with at least one other cell population in non-adherent culture vessels. The present invention relates also to methods of producing de novo papillae usable in said method for producing hair microfollicles.
    Type: Grant
    Filed: March 23, 2009
    Date of Patent: September 23, 2014
    Assignee: Technische Universitat Berlin
    Inventors: Gerd Lindner, Roland Lauster
  • CIRCULATION SYSTEM
    Publication number: 20130295598
    Abstract: A self-contained circulation system, which supports the formation of capillaries in capillary growth sections and allows the formation of micro organoids and/or micro tissue sections for monitoring the effect of one or more test compounds and determining efficacy, side-effects, biosafety, metabolites, mode of action or organ regeneration as well as methods of establishing such micro organoids and/or micro tissue in the self-contained circulation system.
    Type: Application
    Filed: August 5, 2011
    Publication date: November 7, 2013
    Applicant: TECHNISCHE UNIVERSITAET BERLIN
    Inventors: Uwe Marx, Gerd Lindner, Reyk Horland, Silke Hoffman, Roland Lauster
  • Methods for Producing Hair Microfollicles and De Novo Papillae and Their Use for In Vitro Tests and In Vivo Implantations
    Publication number: 20110086079
    Abstract: The present invention relates to a method for producing hair microfollicles comprising the steps of: a) providing de novopapillae, b) providing other cell populations selected from the group of fibroblasts, keratinocytes and melanocytes, and co-culturing the de novopapillae with at least one other cell population in non-adherent culture vessels. The present invention relates also to methods of producing de novo papillae usable in said method for producing hair microfollicles.
    Type: Application
    Filed: March 23, 2009
    Publication date: April 14, 2011
    Inventors: Gerd Lindner, Roland Lauster