Abstract: What is claimed is a process for preparing amino- or hydroxybenzonitriles, in which, in the course of an ammonolysis, the corresponding amino- or hydroxybenzoic acid compounds are reacted with ammonia in the presence of a supported catalyst comprising phosphate at temperatures between 250° C. and 500° C. The actual preparation step is performed in a reaction gas (mixture) and without involvement of an organic solvent, and is followed by an at least 2-stage purification step. In this purification step, the gaseous mixture obtained from the preparation step is first converted to an aqueous basic suspension and then the product present in the solid is released from this suspension. The main advantage of this combination process is that the starting materials are not esters, which is why the resulting products, in contrast to the processes which are otherwise customary, are free of the by-products which are otherwise customary, which leads to a high product purity.

Abstract: A method of isolating 1-[N2-((S)-ethoxycarbonyl)-3-phenylpropyl)-N6-trifluoroacetyl]-L-lysyl-L-proline (lisinopril (TFA) ethyl ester, LPE). The solvent or solvent mixture used for the extraction is also a main constituent of the solvent or solvent mixture from which the crystallization takes place. High yield as well as good purity of the end product are obtained, without distillation. 1-[N2-((S)-ethoxycarbonyl)-3-phenylpropyl)-N6-trifluoroacetyl]-L-lysyl-L-proline (lisinopril (TFA) ethyl ester, LPE) is described as a precursor for producing an ACE inhibitor.

Abstract: Process and apparatus for cutting a running material web in which the material web is wound onto several winding cores in succession, such that winding of the material web onto a new winding core begins after a predetermined diameter has been attained in a wound roll formed on an old winding core. The process includes moving the new winding core between a winding roll and the wound roll, such that the material web is fed onto the wound roll from the winding roll. The process further includes forming a nip between the new winding core and the winding roll, positioning at least one cutting device one of in a region between the wound roll and the nip and in a region upstream of the winding roll relative to a web run direction, and moving the at least one cutting device relative to the material web in a plane substantially parallel to the material web. In this manner, the running material web can be completely cut.

Abstract: Apparatus and process for winding a material web into a wound roll on a winding core. The apparatus includes a press roll, movable press roll bearings coupled to the press roll, and a pressing device positioned to press the press roll against the wound roll. In this manner, the press roll and the wound roll form a winding nip, and the material web is guided the press roll and through the winding nip. The pressing device is adapted to set a line load in the winding nip, and movable winding core bearings are couplable to the winding core of the wound roll and are adapted to move the winding core to compensate for an increasing wound roll diameter. The winding nip one of remains in an at least approximately same position and is displaced by a small amount during winding. A driving device is positioned to move each of the movable winding core bearings, and a control device is arranged to control the driving device as a function of movement of the press roll from a desired position.

Abstract: Process and apparatus for threading a material web onto a reel. The process includes guiding a beginning of the material web to be wound around the drum, directing blower air to keep the material web away from the reel, supplying the material web to a preparation station, and threading the reel with the material web. The apparatus includes a drum positioned to precede the reel, a blower bar arranged cross-wise to a web travel direction and including at least one exit opening adapted to provide blower air, a blower supply device adapted to supply blower air to the blower bar, and a control unit adapted to control activation of the blower air.

Abstract: Winding machine and process for winding a material web, in particular a paper or cardboard web, onto a reel. The material web is guided by a carrying drum that can be supplied with suction, and a nip is formed between the carrying drum and the reel. The carrying drum, which has a perforated casing and/or is provided with circumferential grooves, is supplied with suction by way of at least one external suction box. The suction box is disposed with at least one suction opening opposite the circumference region of the carrying drum that is not wrapped by the material web. The suction box has at least one sealing element that cooperates with the carrying drum in the vicinity of the suction opening.

Abstract: Method for winding a material web onto a reel in an apparatus that includes a rotatable feed roll, a carrying drum, a discharge roll and a pulper. Winding device for winding a material web onto a reel, said winding device including: a feed roll, a carrying drum, and a support belt which is adapted to guide the material web over the feed roll and the carrying drum. An external vacuum device is positioned adjacent a circumferential surface of the carrying drum which is not contacted by the support belt and the material web and a winding nip is formed between the carrying drum and the reel. A discharge roll is provided for guiding the support belt, and the discharge roll is located in the vicinity of a pulper, downstream from the carrying drum, relative to a web run direction. The discharge roll is also adapted to divert at least a portion of the material web to the pulper before feeding the material web to the reel.

Abstract: A winding machine and process for winding a material web onto a reel. The material web is guided around a carrying drum, in which a nip is formed between the carrying drum and the reel. One of the reel and the carrying drum may be cyclically inclined in relation to a travel direction of the material web by a drive device or press device in order to achieve an axial changing of the material web in a winding roll.

Abstract: Process and winding machine for the continuous winding of a web of material onto a reel spool to form a reel. The process includes forming a winding nip between a peripheral zone of a reel drum the reel, guiding the material web over the peripheral zone of the reel drum, positioning the reel in a secondary zone, and displacing and pressing the reel drum against the reel in the secondary zone. In this manner, one of control and regulation of a linear force in the winding nip occurs through the displacement of the reel drum.

Abstract: Winding machine for continuous winding of a material web, in particular a paper or cardboard web, onto a reel into a winding roll, having a movable pressing drum, which forms a winding gap with the winding roll, having at least one primary transport device by means of which the reel can be moved along a first guide track, and at least one secondary transport device that guides the reel along a second guide track. To prepare for a reel change, the new reel can be shifted by the primary transport device into a reel-changing position in which a new winding gap is formed between the new reel and the pressing drum. In the reel-changing position, the material web is guided over a circumference region of the new reel.

Abstract: The invention relates to the production and purification of salts of 6,8-bis (amidiniumthio)octanoic acid, its enantiomers (+)-6,8-bis(amidiniumthio)octanoic acid and (-)-6,8-bis (amidiniumthio)octanoic acid and of the esters of these compounds as well as to their use to produce dihydrolipoic acid and .alpha.-lipoic acid.

Abstract: For winding up of a paper web to form a paper roll, a first reel spool is accelerated to the speed of the web and brought into a first, start-of-winding position in which it forms a nip with a driveable press drum. The beginning of the web of paper is guided around the press drum and is wound onto the first reel spool. When a first layer thickness has been wound, the first reel spool is transferred into a second, complete-winding position and the paper roll is wound up there to its desired layer thickness. During the entire winding process, the press drum or a special press roll are pressed against the winding surface of the developing paper roll, a torque is introduced into the axis of the first reel spool by means of a central drive and the press drum and/or press roll and the first reel spool with the developing paper roll thereon are displaced, preferably exclusively horizontally, without substantial changes in the direction or orientation of those elements.

Abstract: The present invention is relative to a method of producing dry thioctic acid in which a raw material in which concentrated thioctic acid is present is treated with liquid or supercritical CO.sub.2, thus yielding thioctic acid with low residual solvent contents in a simple industrial method.

Abstract: There is provided a process for the work-up of this material having the formula ##STR1## because of its poor crystallizability has heretofore been available only with large yield losses. The yield losses are due to the fact that the crystals of this compound are associated with large amounts of residual solvent material which gives rise to complex and expensive drying procedures. In accordance with the present invention the crude LPE is dried by means of fluid or supercritical carbon dioxide which maces it possible to reduce drying times from the previous range of about 124 hours to about 10 hours for the same amount of product and thus produce a dry LPE which has smaller amounts of residual solvent, as well as smaller by-products than that obtained by conventional drying.

Abstract: A method of isolating 1-?N.sup.2 -((S)-ethoxycarbonyl)-3-phenylpropyl)-N.sup.6 -trifluoroacetyl!-L-lysyl-L-proline (lisinopril (TFA) ethyl ester, LPE). The solvent or solvent mixture used for the extraction is also a main constituent of the solvent or solvent mixture from which the crystallization takes place. High yield as well as good purity of the end product are obtained, without distillation. 1-?N.sup.2 -((S)-ethoxycarbonyl)-3-phenylpropyl)-N.sup.6 -trifluoroacetyl!-L-lysyl-L-proline (lisinopril (TFA) ethyl ester, LPE) is described as a precursor for producing an ACE inhibitor.

Abstract: A method and device for winding a paper web to form a reel. The web is wound onto a shell that is predominantly centrally driven to introduce a torque that winds the web on the shell into a reel. A pressure element extends over the width of the web and acts continuously on the outer surface of the reel being wound in order to squeeze out air. A web threading roll comes adjacent the shell during web threading. Once the web is threaded, the shell is moved generally horizontally from the web threading toward the main winding position where the web is wound. A compensation device supports the reel being wound. The first pressure element in contact with the reel may move away, and a second pressure element closer to the compensation device may press upon the reel, after the first pressure element has moved away.

Abstract: This disclosure describes two technical procedures for the high-yield synthesis of heterocyclic seven-membered ring-systems by Dieckmann-condensation avoiding usual dilution techniques and long reaction times. Thus, it significantly increases the overall yields of the pharmaceutically active ingredients azelastine and flezelastine, whose synthesis, starting from these seven-membered heterocyclic rings, is reported elsewhere. Yields range from 80-89%, avoiding waste and increasing economics of the synthesis.

Abstract: The invention relates to the production and purification of salts of 6,8-bis(amidiniumthio) octanoic acid, its enantiomers (+)-6,8-bis(amidiniumthio)octanoic acid and (-)-6,8-bis (amidiniumthio)octanoic acid and of the esters of these compounds as well as to their use to produce dihydrolipoic acid and .alpha.-lipoic acid.

Abstract: 1. A method of producing flowable R,S-thioctic acid, R,S-thioctic acid and its use.2.1. Known methods of preparing flowable thioctic acid which can be galenically further processed by pressing to highly-concentrated, solid presentations with active-substance contents of more than 200 mg pure substance require the mixing of the thioctic-acid forms of different origins and/or a spraying on of galenic adjuvants from aqueous solution and a subsequent grinding process in order to arrive at a pressable granulate.2.2.

Abstract: RS-thioctic acid with a novel morphology which is obtained by a recrystallization process.