Abstract: The present invention relates to new 14-aminosteroids, pharmaceutical compositions containing the new compounds and methods of treatment for humans or other mammals afflicted with congestive heart failure.

Abstract: The present invention relates to oligosaccharide-containing 14-aminosteroid compounds and the pharmaceutically-acceptable acid salts or esters thereof of the general formula: ##STR1## wherein a) R.sub.1 is(i) COOR.sub.5, whereR.sub.5 is hydrogen, a 1-6 carbon lower alkyl; a 1-6 carbon lower alkyl substituted by an amino group; an arylalkyl or heteroarylalkyl or a carbocyclic ring, or(ii) CHR.sub.6 OH, whereR.sub.6 is a hydrogen atom or 1-6 carbon lower alkyl group, or(iii) COR'", where R'" is hydrogen; 1-6 carbon lower alkyl; 1-6 carbon lower alkyl substituted amino; amino or dialkylamino; andb) R.sub.2 is --NR.sub.7 R.sub.8, whereR.sub.7 and R.sub.8, which may be the same or different, are hydrogen atoms or a 1-6 carbon lower alkyl; andc) R.sub.3 is an oligosaccharide sugar residue; andd) R.sub.4 is(i) OH, or(ii) H, or(iii) OR.sub.13, whereR.sub.13 is a monosaccharide sugar residue; acetoxy; benzoxy; arylalkyl or heteroarylalkyl; ande) Z is(i) --CH--, wherea and b are single bonds, or(ii) .dbd.