Abstract: An interchangeable disposable measuring cassette for insertion into a measuring apparatus for detecting target molecules in a liquid sample by measuring fluorescence emission has a flow measurement cell in which an excitation radiation provided by the measuring apparatus produces an evanescent field in the liquid sample beyond a boundary layer for the liquid sample and the measurement cell. To be better able to ensure that no sample liquid can cross from the measurement cell into the measuring apparatus, the measuring cassette includes a body including an optically transparent material and a base in contact with the underside of the body. The measurement cell is formed by a cutout provided in the body, the base, or both. The areas on which the body and the base are on top of one another around this cutout are connected to one another directly and in fluid-tight fashion by laser welding.

Abstract: An interchangeable disposable measuring cassette for insertion into a measuring apparatus for detecting target molecules in a liquid sample by measuring fluorescence emission has a flow measurement cell in which an excitation radiation provided by the measuring apparatus produces an evanescent field in the liquid sample beyond a boundary layer for the liquid sample and the measurement cell. To be better able to ensure that no sample liquid can cross from the measurement cell into the measuring apparatus, the measuring cassette includes a body including an optically transparent material and a base in contact with the underside of the body. The measurement cell is formed by a cutout provided in the body, the base, or both. The areas on which the body and the base are on top of one another around this cutout are connected to one another directly and in fluid-tight fashion by laser welding.

Abstract: An interchangeable disposable measuring cassette for insertion into a measuring apparatus for detecting target molecules in a liquid sample by measuring fluorescence emission has a flow measurement cell in which an excitation radiation provided by the measuring apparatus produces an evanescent field in the liquid sample beyond a boundary layer for the liquid sample and the measurement cell. To be better able to ensure that no sample liquid can cross from the measurement cell into the measuring apparatus, the measuring cassette includes a body including an optically transparent material and a base in contact with the underside of the body. The measurement cell is formed by a cutout provided in the body, the base, or both. The areas on which the body and the base are on top of one another around this cutout are connected to one another directly and in fluid-tight fashion by laser welding.

Abstract: An automated analysis apparatus having sample, reagent and process rotors, at least three pipetting devices for transferring first and second reagents and a sample, a mixing device, a measuring device, and a flushing device. The analysis apparatus operates in successive operating cycles with the process rotor rotating about its axis of rotation. Simultaneously in each operating cycle in different process containers at different positions of the process rotor a sample is transferred into a process container, the first reagent is transferred into a process container, the second reagent is transferred into a process container, the process mixture is mixed in a process container, the measurement parameter of the process mixture in a process container is measured, and at least one process container is flushed. The rotation of the process rotor is stopped at most twice per operating cycle to transfer a sample and the first and second reagents into a process container.

Abstract: The invention relates to an automatic pipetting device, which comprises at least two pumping units of different capacities and a liquid line, said liquid line opening on one side into a rinsing liquid reservoir and on the other side into a pipetting needle.

Abstract: The present invention concerns a reagent container for liquid reagents comprising a substantially circular sector-shaped, trapezoidal or triangular container bottom and container top and container side walls which extend substantially vertically from the container bottom to the container top and which converge towards each other from a container rear wall to a container front side, wherein the container top has an opening. In order to be able to fit reagent containers of various sizes into a reagent carousel in exactly positioned and reliably fixed relationship it is proposed in accordance with the invention that provided at at least one container side wall of the reagent container is at least one positioning groove or positioning abutment surface which starts from the container bottom and extends vertically in the direction of the container top.

Abstract: In a winding apparatus for endless threads, a revolving disc (6) has at least two clamping chucks (8, 10) rotatably supported on the periphery thereof. A friction roll (2), the shaft (4) of which as well as the shaft (12) of the revolving disc (6) are mounted in a frame (14) at fixed locations. The shaft (12) is connected to a first drive device (120) and the first shaft (4) is connected to a second drive device (40). Each clamping chuck (8, 10) is provided with its own third drive device (80), and fourth drive device (100) respectively.

Abstract: In a winding apparatus for endless threads with a revolving disc (6) in the periphery of which at least two clamping chucks (8, 10) are rotatably supported and with a friction roll (2) the shaft of which as well as the shaft (12) of the revolving disc (6) are mounted at fixed locations in a frame, a shaft each (4, 12) is connected to a first drive device (120), and with a second drive device (40) respectively. Each clamping chuck is provided with its own third drive device (80), and a fourth drive device (100) respectively. The contacting pressure between the friction roll (2) and a respective clamping chuck each can be adjusted as a function of the diameter of a thread package being built on a clamping chuck.

Abstract: The present invention provides a process for the determination of a specifically bindable substance by incubation of the sample solution with at least three receptors R.sub.1, R.sub.2 and R.sub.3, of which R.sub.1 and R.sub.2 are bindable with one another and R.sub.3 is specifically bindable with the substance to be determined and measurement of the agglutination which takes place in the case of the reaction, wherein, as receptor R.sub.1, there is used a conjugate of a partner of a specifically binding pair P and of a substance S which corresponds to the substance to be determined or is a derivative thereof and has at least one epitope of the substance to be determined, as receptor R.sub.2 there is used a receptor which has at least two binding positions for P and as receptor R.sub.3 there is used a receptor which has at least two binding positions, of which at least one binds specifically with an epitope of the substance to be determined or of S.

Abstract: The application describes homogeneous assays for determining ligands. A sample is contacted with a labeled substance P.sub.2 and receptor R. The receptor R consists of one molecule of P.sub.1, which monovalently and specifically binds to P.sub.2, and one molecule for R.sub.1, which binds to the ligand of interest. Complexes of P.sub.1, P.sub.2, R.sub.1 and ligand form, and are determined. R.sub.1 must be a nucleic acid molecule.

Abstract: Method for the immunological determination of a ligand in which the ligand to be determined is reacted witha) at least 2 molecules of a specifically bindable substance P2 of which at least one of these molecules carries a label andb) a receptor R which consists of a binding partner P1 which is capable of monovalent binding to P2 and a binding site R.sub.1 for the ligand to be determined and then the label is determined,as well as a reagent for the immunological determination of a ligand which contains a specifically bindable substance P2 which is present at least partially in labelled form and a receptor R which consists of a binding partner P1 which is capable of monovalent binding to P2 and a binding site R.sub.1 for the ligand to be determined.

Abstract: For the determination of a specifically bindable substance by incubation of the sample solution with at least two receptors R.sub.1 and R.sub.2, whereby R.sub.1 and R.sub.2 are capable of binding to each other and R.sub.1 is capable of specific binding to the substance to be determined and measurement of the agglutination which occurs in the reaction, a conjugate of one partner of a specific binding pair P and a component K capable of specific binding to the substance to be determined is used as the receptor R.sub.1 and a receptor which has at least two binding sites for P is used as R.sub.2.

Abstract: The invention provides a cleaning solution and a method of using the cleaning solution for cleaning diagnostic analyzers. The solution contains a rapidly wetting surfactant and an inorganic or organic acid. The invention provides rapid and effective cleaning of proteins from all types of materials used for components of automatic analyzers.

Abstract: Hapten-biotin conjugates in which the hapten is linked with biotin via a spacer, which has 26 to 40 atoms in its chain and contains at least 5 heteroatoms, are novel and are suitable, in particular for use in a competitive homogeneous immunoassay in which the agglutination which occurs in the reaction is evaluated by turbidimetric or nephelometric measurements.

Abstract: The present invention provides a process for the determination of a specifically bindable substance by incubation of a sample solution with at least three receptors R.sub.1, R.sub.2 and R.sub.3, of which R.sub.1 is specifically bindable with R.sub.2 and R.sub.3, as well as with the substance to be determined, R.sub.2 brings about the binding to a solid phase and R.sub.3 carries a labelling, separation of bound labelling from unbound labelling and measurement of the labelling in one of the two phases, wherein, as receptor R.sub.1, a receptor is used which has at least two binding positions which bind specifically with an epitope of the substance to be determined, as R.sub.2 a conjugate of a partner P.sub.1 of a specifically binding pair and of a substance S which corresponds to the substance to be determined or is a derivative thereof and has at least one epitope of the substance to be determined, the partner P.sub.1 thereby either being bound to a solid phase or being immobilized, and as R.sub.