Patents by Inventor Roland Selig

Roland Selig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH
    Publication number: 20240116931
    Abstract: The invention relates to pyrazolo-pyridine compounds which inhibit mitogen-activated protein kinase kinase 4 (MKK4) and in particular, selectively inhibit MKK4 over protein kinases JNK1 and MKK7. The compounds are useful for promoting liver regeneration or reducing or preventing hepatocyte death. They are further useful for treating osteoarthritis or rheumatoid arthritis, or CNS-related diseases.
    Type: Application
    Filed: November 8, 2023
    Publication date: April 11, 2024
    Applicant: HEPAREGENIX GMBH
    Inventors: Brent PRAEFKE, Philip KLÖVEKORN, Roland SELIG, Wolfgang ALBRECHT, Stefan LAUFER
  • Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
    Patent number: 11912701
    Abstract: The invention relates to compounds of formula (I) which are inhibitors of MKK4 (mitogen-activated protein kinase kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The compounds selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7. (I), wherein Rx, Ry, Rz and Rzz are selected from: a) Rx and Ry are F and Rz and Rzz are H; b) Rx, Ry and Rzz are independently halogen and Rz is H; c) Rx Rz and Rzz are independently halogen and Ry is H; and d) Rx Ry and Rz are independently halogen and Rzz is H.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: February 27, 2024
    Assignee: HepaRegeniX GmbH
    Inventors: Wolfgang Albrecht, Stefan Laufer, Roland Selig, Phillip Klövekorn, Bent Präfke
  • Protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
    Patent number: 11858927
    Abstract: The invention relates to pyrazolo-pyridine compounds which inhibit mitogen-activated protein kinase kinase 4 (MKK4) and in particular, selectively inhibit MKK4 over protein kinases JNK1 and MKK7. The compounds are useful for promoting liver regeneration or reducing or preventing hepatocyte death. They are further useful for treating osteoarthritis or rheumatoid arthritis, or CNS-related diseases.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: January 2, 2024
    Assignee: HepaRegeniX GmbH
    Inventors: Bent Praefke, Philip Klövekorn, Roland Selig, Wolfgang Albrecht, Stefan Laufer
  • Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
    Patent number: 11731968
    Abstract: Tricyclic mitogen-activated protein kinases kinase 4 (MKK4) inhibitor compounds useful for promoting liver regeneration or reducing hepatocyte death by selectively inhibiting MKK4 over protein kinases JNK and MKK7.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: August 22, 2023
    Assignee: HepaRegeniX GmbH
    Inventors: Michael Juchum, Roland Selig, Stefan Laufer, Wolfgang Albrecht
  • 3-BENZOYL-1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS MKK4 INHIBITORS FOR TREATING LIVER DISEASES
    Publication number: 20230088395
    Abstract: The invention relates to compounds of formula (I) which are inhibitors of MKK4 (mitogen-activated protein kinase kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The compounds selectively inhibit protein kinase MKK4 over protein kinases JNK1 and MKK7. In formula (I), especially, Rw is —NR10SO2R12; either a) Rx and Ry are F and Rz and Rzz are H; or b) Rx, Ry and Rzz are independently halogen and Rz is H; R5 is substituted phenyl or pyrimidinyl.
    Type: Application
    Filed: January 13, 2021
    Publication date: March 23, 2023
    Inventors: Roland SELIG, Stefan LAUFER, Wolfgang ALBRECHT
  • HETEROARYL-SUBSTITUTED PYRAZOLO-PYRIDINE PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH
    Publication number: 20220340561
    Abstract: The invention relates to pyrazolo-pyridine compounds which inhibit mitogen-activated protein kinase kinase 4 (MKK4) and in particular, selectively inhibit MKK4 over protein kinases JNK1 and MKK7. The compounds are useful for promoting liver regeneration or reducing or preventing hepatocyte death. They are further useful for treating osteoarthritis or rheumatoid arthritis, or CNS-related diseases.
    Type: Application
    Filed: July 27, 2020
    Publication date: October 27, 2022
    Inventors: Bent PFAFFENROT, Roland SELIG, Stefan LAUFER, Wolfgang ALBRECHT
  • PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH
    Publication number: 20220281864
    Abstract: The invention relates to compounds of formula (I) which are inhibitors of MKK4 (mitogen-activated protein kinase kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The compounds selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7.
    Type: Application
    Filed: July 16, 2019
    Publication date: September 8, 2022
    Inventors: Wolfgang ALBRECHT, Stefan LAUFER, Roland SELIG, Phillip KLÖVEKORN, Bent PRÄFKE
  • TRICYCLIC PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH
    Publication number: 20210261545
    Abstract: The invention relates to tricyclic compounds which are MKK4 (mitogen-activated protein kinase kinase 4) inhibitors which selectively inhibit protein kinase kinase MKK4 over protein kinases JNK and MKK7. They are useful for promoting liver regeneration or reducing or preventing hepatocyte death.
    Type: Application
    Filed: June 18, 2019
    Publication date: August 26, 2021
    Inventors: Michael JUCHUM, Roland SELIG, Stefan LAUFER, Wolfgang ALBRECHT
  • Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
    Patent number: 11040027
    Abstract: The invention relates to MKK4 (mitogen-activated protein kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The MKK4 inhibitors selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: June 22, 2021
    Assignee: Heparegenix GMBH
    Inventors: Wolfgang Albrecht, Stefan Laufer, Roland Selig, Phillip Klövekorn, Bent Präfke
  • PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH
    Publication number: 20210078995
    Abstract: The invention relates to pyrazolo-pyridine compounds which inhibit mitogen-activated protein kinase kinase 4 (MKK4) and in particular, selectively inhibit MKK4 over protein kinases JNK1 and MKK7. The compounds are useful for promoting liver regeneration or reducing or preventing hepatocyte death. They are further useful for treating osteoarthritis or rheumatoid arthritis, or CNS-related diseases.
    Type: Application
    Filed: January 30, 2019
    Publication date: March 18, 2021
    Inventors: Bent PRAEFKE, Philip KLÖVEKORN, Roland SELIG, Wolfgang ALBRECHT, Stefan LAUFER
  • PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH
    Publication number: 20190365723
    Abstract: The invention relates to MKK4 (mitogen-activated protein kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The MKK4 inhibitors selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7.
    Type: Application
    Filed: January 17, 2018
    Publication date: December 5, 2019
    Inventors: Wolfgang Albrecht, Stefan Laufer, Roland Selig, Phillip Klövekorn, Bent Präfke
  • MMF-derivatives of ethyleneglycols
    Patent number: 9969674
    Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis, rheumatoid arthritis and psoriasis.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: May 15, 2018
    Assignee: ratiopharm GmbH
    Inventors: Wolfgang Albrecht, Roland Selig, Frank Lehmann, Richard Guserle, Annemarie Maier
  • Prodrugs of monomethyl fumarate (MMF)
    Patent number: 9868690
    Abstract: The present invention relates to novel compounds for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: January 16, 2018
    Assignee: ratiopharm GmbH
    Inventors: Wolfgang Albrecht, Roland Selig, Sebastian Rabe, Richard Guserle, Annemarie Maier
  • Derivatives of polyhydroxy compounds
    Patent number: 9796659
    Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: October 24, 2017
    Assignee: ratiopharm GmbH
    Inventors: Wolfgang Albrecht, Frank Lehmann, Roland Selig, Sebastian Rabe, Annemarie Maier, Richard Guserle
  • BIS-MMF derivatives
    Patent number: 9663480
    Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel medicaments, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, or inflammatory diseases, for example multiple sclerosis and psoriasis.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: May 30, 2017
    Assignee: ratiopharm GmbH
    Inventors: Wolfgang Albrecht, Roland Selig, Sebastian Rabe, Annemarie Maier, Richard Guserle
  • Derivatives of tartaric acid
    Patent number: 9593068
    Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel medicaments, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, and/or inflammatory diseases, for example multiple sclerosis and psoriasis.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: March 14, 2017
    Assignee: ratiopharm GmbH
    Inventors: Wolfgang Albrecht, Roland Selig, Sebastian Rabe, Annemarie Maier, Richard Guserle
  • MMF-DERIVATIVES OF ETHYLENEGLYCOLS
    Publication number: 20170029357
    Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis, rheumatoid arthritis and psoriasis.
    Type: Application
    Filed: April 16, 2015
    Publication date: February 2, 2017
    Inventors: Wolfgang ALBRECHT, Roland SELIG, Frank LEHMANN, Richard GUSERLE, Annemarie MAIER
  • DERIVATIVES OF POLYHYDROXY COMPOUNDS
    Publication number: 20170001945
    Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis.
    Type: Application
    Filed: February 27, 2015
    Publication date: January 5, 2017
    Inventors: Wolfgang ALBRECHT, Frank LEHMANN, Roland SELIG, Sebastian RABE, Annemarie MAIER, Richard GUSERLE
  • DERIVATIVES OF TARTARIC ACID
    Publication number: 20160326090
    Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel medicaments, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, and/or inflammatory diseases, for example multiple sclerosis and psoriasis.
    Type: Application
    Filed: December 4, 2014
    Publication date: November 10, 2016
    Applicant: RATIOPHARM GMBH
    Inventors: Wolfgang ALBRECHT, Roland SELIG, Sebastian RABE, Annemarie MAIER, Richard GUSERLE
  • BIS-MMF DERIVATIVES
    Publication number: 20160289201
    Abstract: The present invention relates to novel compounds, e.g. for use as a medicament. In particular, the present invention relates to novel medicaments, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, or inflammatory diseases, for example multiple sclerosis and psoriasis.
    Type: Application
    Filed: December 4, 2014
    Publication date: October 6, 2016
    Applicant: Ratiopharm GMBH
    Inventors: Wolfgang ALBRECHT, Roland SELIG, Sebastian RABE, Annemarie MAIER, Richard GUSERLE