Abstract: The technology relates to a method for detecting high-risk unstable atherosclerotic plaque in a subject, the method comprising: a) administering to the subject a magnetic resonance imaging (MRI) contrast agent capable of being activated by myeloperoxidase (MPO) in atherosclerotic plaque; b) allowing the contrast agent to be activated by myeloperoxidase in atherosclerotic plaque; c) obtaining an image of the atherosclerotic plaque from the subject using such molecular MRI, wherein enhanced imaging is indicative of unstable plaque. In some embodiments an MPO inhibitor is administered to a subject identified as having a high-risk unstable atherosclerotic plaque.

Abstract: A transmission for a motorcycle includes a housing; at least one shaft at least partially accommodated in the housing, a locking device which has at least one first locking element which can be rotated with the shaft and at least one second locking element which can be moved relative to the housing, relative to the shaft, and relative to the first locking element. The second locking element can move between at least one release position in which the locking elements do not engage in one another and the shaft is released for rotation, and at least one locking position in which the locking elements engage in one another to secure the shaft against rotation relative to the housing. The transmission further includes an actuating device configured to move the second locking element out of the release position into the locking position via at least one intermediate position.

Abstract: A transmission for a motorcycle includes a housing, at least one shaft at least partially accommodated in the housing and which can be rotated relative to the housing, and a locking device having at least one locking element located in the housing. The at least one locking element is movable moved relative to the housing between at least one locking position in which the at least one locking element secures the shaft against rotation relative to the housing, and at least one release position in which the at least one locking element releases the shaft for rotation relative to the housing.

Abstract: The technology relates to a method for detecting high-risk unstable atherosclerotic plaque in a subject, the method comprising: a) administering to the subject a magnetic resonance imaging (MRI) contrast agent capable of being activated by myeloperoxidase (MPO) in atherosclerotic plaque; b) allowing the contrast agent to be activated by myeloperoxidase in atherosclerotic plaque; c) obtaining an image of the atherosclerotic plaque from the subject using such molecular MRI, wherein enhanced imaging is indicative of unstable plaque. In some embodiments an MPO inhibitor is administered to a subject identified as having a high-risk unstable atherosclerotic plaque.

Abstract: A transmission for a motorcycle includes a housing, at least one shaft at least partially accommodated in the housing and which can be rotated relative to the housing, and a locking device having at least one locking element located in the housing. The at least one locking element is movable moved relative to the housing between at least one locking position in which the at least one locking element secures the shaft against rotation relative to the housing, and at least one release position in which the at least one locking element releases the shaft for rotation relative to the housing.

Abstract: A transmission for a motorcycle includes a housing; at least one shaft at least partially accommodated in the housing, a locking device which has at least one first locking element which can be rotated with the shaft and at least one second locking element which can be moved relative to the housing, relative to the shaft, and relative to the first locking element. The second locking element can move between at least one release position in which the locking elements do not engage in one another and the shaft is released for rotation, and at least one locking position in which the locking elements engage in one another to secure the shaft against rotation relative to the housing. The transmission further includes an actuating device configured to move the second locking element out of the release position into the locking position via at least one intermediate position.

Abstract: Herein provided is a method for evaluating the antioxidant potential of a biological sample comprising the steps of: (a) collecting a sample containing at least oxidizable substrates from a living body; (b) initiating an oxidation reaction of said oxidizable substrates; (c) continuing said oxidation reaction; and (d) quantifying oxidation products formed from said oxidizable substrates by determining the rate of said oxidation reaction during the progress thereof or by performing an assay after said oxidation reaction has been stopped, wherein said steps (b) and (c) are performed in the presence of one or more antioxidant components.

Abstract: The present invention relates compositions and methods for the prophylactic or therapeutic treatment of cardiovascular diseases, particularly restenosis and atherosclerosis. These compositions comprise an effective promotor of re-endothelialization, preferably probucol or an analogue thereof, and an inhibitor of lipoprotein oxidation, preferably a probucol-derived bisphenol. Alternatively, the said compositions may comprise a compound that possesses both re-endothelialization-promoting and lipoprotein oxidation-inhibitory effects. This invention further relates to compositions and methods for promoting re-endothelialization.

Abstract: The present invention relates to compositions and methods for prophylactic or therapeutic treatment of cardiovascular diseases, particularly restenosis and atherosclerosis. The invention further relates to compositions and methods for promoting re-endothelialization.

Abstract: Disclosed is a method for screening and/or testing in vitro of synthetic or natural compounds for antioxidant potency. Further disclosed is the use of 3,3',5,5'-tetra-tert-butyl-4,4'-bisphenol and pharmaceutical preparations thereof in restoring endothelial function.