Patents by Inventor Roland Suck

Roland Suck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA sequence and preparation of grass pollen allergen Phl p 4 by recombinant methods
    Patent number: 9556241
    Abstract: The present invention relates to the preparation and use of recombinant variants of group 6 allergens of the Poaceae (true grasses), which are characterized by reduced IgE reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with T-lymphocytes.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: January 31, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Helmut Fiebig, Andreas Nandy, Roland Suck, Oliver Cromwell, Arnd Petersen, Wolf-Meinhard Becker
  • Variants of the major allergen Phl P 1 from timothy grass
    Patent number: 9453058
    Abstract: The invention relates to pharmaceutically important variants of the major allergen Phl p 1 from timothy grass, characterized in that a preparation, hitherto not possible, of monomeric molecules which are soluble and stable in physiological media can be carried out with the aid of prokaryotic expression systems and subsequent purification thereof.
    Type: Grant
    Filed: March 22, 2010
    Date of Patent: September 27, 2016
    Assignee: Merck Patent GmbH
    Inventors: Roland Suck, Helmut Fiebig, Oliver Cromwell
  • Process for the preparation of hypoallergenic major birch pollen allergen rBet v 1
    Patent number: 9441021
    Abstract: The invention relates to a process for the preparation of hypoallergenic major birch pollen allergens by means of one or more chromatographic purification steps using essentially unbuffered aqueous bases as eluent and subsequent neutralization. The hypoallergenic major birch pollen allergens are distinguished by a lack of, but at least by reduced immunoglobulin E binding with simultaneous retention of therapeutically relevant T-cell stimulation. They can therefore be employed as low-side-effect therapeutic agents for specific immunotherapy.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: September 13, 2016
    Assignee: MERCK PATENT GMBH
    Inventors: Roland Suck, Helmut Fiebig, Oliver Cromwell
  • DNA sequence and preparation of grass pollen allergen Phl p 4 by recombinant methods
    Patent number: 9120866
    Abstract: The present invention relates to the provision of the genetic sequence of the major grass pollen allergen Phl p 4. The invention also covers fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilized for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for the in vitro and in vivo diagnosis of pollen allergies.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: September 1, 2015
    Assignee: MERCK PATENT GMBH
    Inventors: Helmut Fiebig, Andreas Nandy, Roland Suck, Oliver Cromwell, Arnd Petersen, Wolf-Meinhard Becker
  • DNA SEQUENCE AND PREPARATION OF GRASS POLLEN ALLERGEN PHL P4 BY RECOMBINANT METHODS
    Publication number: 20150079120
    Abstract: The present invention relates to the preparation and use of recombinant variants of group 6 allergens of the Poaceae (true grasses), which are characterised by reduced IgE reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with T-lymphocytes.
    Type: Application
    Filed: November 21, 2014
    Publication date: March 19, 2015
    Applicant: Merck Patent GmbH
    Inventors: Helmut FIEBIG, Andreas NANDY, Roland SUCK, Oliver CROMWELL, Arnd PETERSEN, Wolf-Meinhard BECKER
  • Method for isolating and purifying grass pollen allergens
    Patent number: 8329185
    Abstract: The invention relates to a method for quickly and effectively isolating and purifying five, namely the group 1, 2, 3, 10 and 13 allergens from grass pollen. The purification of said grass pollen is based on the inventive combination of hydrophobic interaction chromatography, gel filtration and cation exchange chromatography. The proteins obtained by the inventive method facilitate an improved diagnosis of pollen allergies and are used in pharmaceutical preparations for the therapy of pollenogenic diseases.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: December 11, 2012
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Roland Suck, Oliver Cromwell, Helmut Fiebig
  • DNA SEQUENCE AND PREPARATION OF GRASS POLLEN ALLERGEN PHL P4 BY RECOMBINANT METHODS
    Publication number: 20120288526
    Abstract: The present invention relates to the provision of the genetic sequence of the major grass pollen allergen Phl p 4. The invention covers fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for the in vitro and in vivo diagnosis of pollen allergies.
    Type: Application
    Filed: February 24, 2011
    Publication date: November 15, 2012
    Applicant: Merck Patent GmbH
    Inventors: HELMUT FIEBIG, ANDREAS NANDY, ROLAND SUCK, OLIVER CROMWELL, ARND PETERSEN, WOLF-MEINHARD BECKER
  • VARIANTS OF THE MAJOR ALLERGEN PHL P 1 FROM TIMOTHY GRASS
    Publication number: 20120263741
    Abstract: The invention relates to pharmaceutically important variants of the major allergen Phl p 1 from timothy grass, characterised in that a preparation, hitherto not possible, of monomeric molecules which are soluble and stable in physiological media can be carried out with the aid of prokaryotic expression systems and subsequent purification thereof.
    Type: Application
    Filed: March 22, 2010
    Publication date: October 18, 2012
    Inventors: Roland SUCK, Helmut Fiebig, Oliver Cromwell
  • DNA sequence and recombinant production of the grass pollen allergen Phl p 4
    Patent number: 8128935
    Abstract: The present invention relates to the provision of the genetic sequence of the major grass pollen allergen Phl p 4. The invention also covers fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for the in vitro and in vivo diagnosis of pollen allergies.
    Type: Grant
    Filed: June 11, 2003
    Date of Patent: March 6, 2012
    Assignee: Merck Patent GmbH
    Inventors: Helmut Fiebig, Andreas Nandy, Roland Suck, Oliver Cromwell, Arnd Petersen, Wolf-Meinhard Becker
  • Insect poison allergens with reduced IgE reactivity and method for producing the same
    Patent number: 8048424
    Abstract: The invention relates to recombinant insect poison allergens and to a specific method for producing them. Said allergens can be varied according to whether they are produced using folds (conformations) that are identical or different to those that occur naturally. The proteins with folds that do not occur naturally have a reduced IgE reactivity or allergenity and can therefore be used as therapeutic agents in the immunotherapy of allergies.
    Type: Grant
    Filed: August 9, 2007
    Date of Patent: November 1, 2011
    Assignee: Merck Patent GmbH
    Inventors: Roland Suck, Oliver Cromwell, Helmut Fiebig
  • Variants of the major allergen Phl p 1 from timothy grass
    Patent number: 7731970
    Abstract: The invention relates to pharmaceutically important variants of the major allergen Phl p 1 from timothy grass, characterized in that a preparation, hitherto not possible, of monomeric molecules which are soluble and stable in physiological media can be carried out with the aid of prokaryotic expression systems and subsequent purification thereof.
    Type: Grant
    Filed: July 31, 2003
    Date of Patent: June 8, 2010
    Assignee: Merck Patent GmbH
    Inventors: Roland Suck, Helmut Fiebig, Oliver Cromwell
  • PROCESS FOR THE PREPARATION OF HYPOALLERGENIC MAJOR BIRCH POLLEN ALLERGEN rBet v 1
    Publication number: 20090069236
    Abstract: The invention relates to a process for the preparation of hypoallergenic major birch pollen allergens by means of one or more chromatographic purification steps using essentially unbuffered aqueous bases as eluent and subsequent neutralisation. The hypoallergenic major birch pollen allergens are distinguished by a lack of, but at least by reduced immunoglobulin E binding with simultaneous retention of therapeutically relevant T-cell stimulation. They can therefore be employed as low-side-effect therapeutic agents for specific immunotherapy.
    Type: Application
    Filed: July 3, 2008
    Publication date: March 12, 2009
    Inventors: Roland SUCK, Helmut Fiebig, Oliver Cromwell
  • Method for isolating and purifying grass pollen allergens
    Publication number: 20080118991
    Abstract: The invention relates to a method for quickly and effectively isolating and purifying five, namely the group 1, 2, 3, 10 and 13 allergens from grass pollen. The purification of said grass pollen is based on the inventive combination of hydrophobic interaction chromatography, gel filtration and cation exchange chromatography. The proteins obtained by the inventive method facilitate an improved diagnosis of pollen allergies and are used in pharmaceutical preparations for the therapy of pollenogenic diseases.
    Type: Application
    Filed: December 13, 2007
    Publication date: May 22, 2008
    Inventors: Roland Suck, Oliver Cromwell, Helmut Fiebig
  • Method for isolating and purifying grass pollen allergens
    Publication number: 20080118536
    Abstract: The invention relates to a method for quickly and effectively isolating and purifying five, namely the group 1, 2, 3, 10 and 13 allergens from grass pollen. The purification of said grass pollen is based on the inventive combination of hydrophobic interaction chromatography, gel filtration and cation exchange chromatography. The proteins obtained by the inventive method facilitate an improved diagnosis of pollen allergies and are used in pharmaceutical preparations for the therapy of pollenogenic diseases.
    Type: Application
    Filed: December 13, 2007
    Publication date: May 22, 2008
    Inventors: Roland Suck, Oliver Cromwell, Helmut Fiebig
  • Method for isolating and purifying grass pollen allergens
    Patent number: 7326769
    Abstract: The invention relates to a method for quickly and effectively isolating and purifying five, namely the group 1, 2, 3, 10 and 13 allergens from grass pollen. The purification of said grass pollen is based on the inventive combination of hydrophobic interaction chromatography, gel filtration and cation exchange chromatography. The proteins obtained by the inventive method facilitate an improved diagnosis of pollen allergies and are used in pharmaceutical preparations for the therapy of pollenogenic diseases.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: February 5, 2008
    Assignee: Merck Patentgesellschaft Mit Beschrankter Haftung
    Inventors: Roland Suck, Oliver Cromwell, Helmut Fiebig
  • Insect poison allergens with reduced IgE reactivity and method for producing the same
    Publication number: 20070280884
    Abstract: The invention relates to recombinant insect poison allergens and to a specific method for producing them. Said allergens can be varied according to whether they are produced using folds (conformations) that are identical or different to those that occur naturally. The proteins with folds that do not occur naturally have a reduced IgE reactivity or allergenity and can therefore be used as therapeutic agents in the immunotherapy of allergies.
    Type: Application
    Filed: August 9, 2007
    Publication date: December 6, 2007
    Inventors: Roland Suck, Oliver Cromwell, Helmut Fiebig
  • Insect poison allergens with reduced IgE reactivity and method producing the same
    Patent number: 7285397
    Abstract: The invention relates to recombinant insect poison allergens and to a specific method for producing them. Said allergens can be varied according to whether they are produced using folds (conformations) that are identical or different to those that occur naturally. The proteins with folds that do not occur naturally have a reduced IgE reactivity or allergenity and can therefore be used as therapeutic agents in the immunotherapy of allergies.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: October 23, 2007
    Assignee: Merck Patent GmbH
    Inventors: Roland Suck, Oliver Cromwell, Helmut Fiebig
  • DNA sequence and recombinant production of a Gramineae allergen
    Patent number: 7241450
    Abstract: The invention relates to the identification and characterization of a grass-pollen allergen, and to the recombinant DNA molecule encoding therefore, and to corresponding DNA and peptide sequences.
    Type: Grant
    Filed: April 12, 2000
    Date of Patent: July 10, 2007
    Assignee: Merck Patent GmbH
    Inventors: Helmut Fiebig, Roland Suck, Oliver Cromwell
  • Variants of the major allergen phl p 1 from timothy grass
    Publication number: 20060251682
    Abstract: The invention relates to pharmaceutically important variants of the major allergen Phl p 1 from timothy grass, characterised in that a preparation, hitherto not possible, of monomeric molecules which are soluble and stable in physiological media can be carried out with the aid of prokaryotic expression systems and subsequent purification thereof.
    Type: Application
    Filed: July 31, 2003
    Publication date: November 9, 2006
    Inventors: Roland Suck, Helmut Fiebig, Oliver Cromwell
  • Dna sequence and recombinant production of the grass pollen allergen phl p4
    Publication number: 20060177470
    Abstract: The present invention relates to the provision of the genetic sequence of the major grass pollen allergen Phl p 4. The invention also covers fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for the in vitro and in vivo diagnosis of pollen allergies.
    Type: Application
    Filed: June 11, 2003
    Publication date: August 10, 2006
    Inventors: Helmut Fiebig, Andreas Nandy, Roland Suck, Oliver Cromwell, Arnd Petersen, Wolf-Meinhard Becker