Patents by Inventor Roland Wehr

Roland Wehr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic tetrahydrothiazepine derivatives useful for the treatment of neoplastic and/or infectious diseases
    Patent number: 10472341
    Abstract: The present invention relates to bicyclic tetrahydrothiazepine of formula (I), wherein R1 to R3, X1, X2 and R18 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising such compounds as well as their use as medicaments, especially in methods for the treatment or prevention of a neoplastic and/or infectious disease and in vitro methods.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: November 12, 2019
    Assignees: APEIRON BIOLOGICS AG, EVOTEC SE
    Inventors: Monika Ermann, Guenther Lametschwandtner, Patricia Leonie Amouzegh, Russell Stuart Craft, Thomas Hanke, Timothy Robin James, Severine Danielle Jones, Hans Loibner, Pui Leng Loke, Ina Sternberger, Anton Stuetz, Roland Wehr, Mark Whittaker
  • BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEOPLASTIC AND/OR INFECTIOUS DISEASES
    Publication number: 20180170888
    Abstract: The present invention relates to bicyclic tetrahydrothiazepine of formula (I), wherein R1 to R3, X1, X2 and R18 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising such compounds as well as their use as medicaments, especially in methods for the treatment or prevention of a neoplastic and/or infectious disease and in vitro methods.
    Type: Application
    Filed: February 29, 2016
    Publication date: June 21, 2018
    Inventors: Monika ERMANN, Guenther LAMETSCHWANDTNER, Patricia Leonie AMOUZEGH, Russell Stuart CRAFT, Thomas HANKE, Timothy Robin JAMES, Severine Danielle JONES, Hans LOIBNER, Pui Leng LOKE, Ina STERNBERGER, Anton STUETZ, Roland WEHR, Mark WHITTAKER
  • USE OF PAX4 IN PANCREATIC CELL PROLIFERATION
    Publication number: 20100135963
    Abstract: The present invention relates to an in vitro method for the generation and isolation of pancreatic ?-cells, comprising the steps of (a) contacting an adult cell derived from mammalian pancreatic islets or an explant culture of adult pancreatic islets with functional, wild-type Pax4; and (b) detecting and isolating; from said adult cell or explant culture, ?-cells that proliferate in response to the contact with Pax4. Furthermore, the use of functional; wild-type Pax4 for the preparation of a pharmaceutical composition for transplantation and/or tissue replacement is described.
    Type: Application
    Filed: August 9, 2005
    Publication date: June 3, 2010
    Inventors: Benoit Raymond Gauthier, Thierry Brun, Claes Benedict Wollheim, Roland Wehr
  • Modifier of Organelle Metabolism
    Publication number: 20080226638
    Abstract: Provided herein are methods for the treatment of metabolism disorders by delivering a therapeutically effective amount of a modulator of a SOUP1 polypeptide. The invention also relates to a nucleic acid molecule encoding a polypeptide contributing to membrane stability and/or function of organelles.
    Type: Application
    Filed: January 5, 2007
    Publication date: September 18, 2008
    Applicant: DEVELOGEN AG FUR ENTWICKLUNGSBIOLOGISCHE FORSCHUNG
    Inventors: Arnd Steuernagel, Gunter Bronner, Cord Dohrmann, Thomas Ciossek, Roland Wehr, Bettina Rudolph, Dorothea Rudolph
  • Endophilin homologous proteins involved in the regulation of energy homeostasis
    Publication number: 20050176659
    Abstract: The present invention discloses Endophilin homologous proteins regulating the energy homeostasis and the metabolism of triglycerides, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders, for example, but not limited to, metabolic diseases such as obesity as well as related disorders such as eating disorder, cachexia, diabetes mellitus, hypertension, coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, cancers of the reproductive organs, and sleep apnea.
    Type: Application
    Filed: November 8, 2002
    Publication date: August 11, 2005
    Inventors: Bettina Rudolph, Ursula Hoffmann, Karsten Eulenberg, Roland Wehr, Gunter Bronner, Arnd Steuernagel, Thomas Hader