Abstract: The Present disclosure relates to lipases comprising an amino acid sequence which has at least 70% sequence identity with the amino acid sequence specified in SEQ ID NO:1 over the entire length thereof and which have an amino acid substitution in at least one of the positions S93, P145, L156, K169, N193, G202, Q225, K235, V236, P260, H298, P308, F311, N328, L352, D359 or S364, referring in each case to the numbering according to SEQ ID NO:1, and the production and use thereof. Lipases of such kind have very good stability, particularly thermal stability, and at the same time good cleaning power.

Abstract: The invention relates to a method for producing a composite body and to a composite body produced using the method, wherein the composite body (10) is formed as a pressure pipe or as a pressure container, wherein the composite body is composed of a main body (13) that is made of steel and of a coat (14) that is made of a fiber composite (15), said coat enclosing the outside of the main body at least in some sections, wherein, for forming the fiber composite, a fibrous material is wound around the main body, wherein the fibrous material is impregnated with a resin before or after winding, wherein the wound and impregnated fibrous material is heated in order to form the fiber composite, wherein the method is carried out in situ on a built-in pressure pipe or pressure container, wherein the wound and impregnated fibrous material is heated to up to 700° C.

Abstract: The present invention relates to a genetically modified yeast cell comprising: —at least one recombinant promoter operably linked to at least one gene encoding a polypeptide or protein supporting the biosynthesis of polypeptides or proteins within said cell, said at least one gene being located at the native genomic locus of the genetically unmodified wild-type yeast cell, wherein the naturally occurring promoter of the at least one gene encoding the biosynthesis supporting polypeptide or protein is inactivated by at least one mutation within said naturally occurring promoter and, —a secretion cassette comprising a recombinant nucleic acid molecule encoding a protein or polypeptide of interest and a method for producing a recombinant protein or polypeptide of interest using such a cell.

Abstract: The invention relates to a method for producing a composite body and to a composite body produced using the method, wherein the composite body (10) is formed as a pressure pipe or as a pressure container, wherein the composite body is composed of a main body (13) that is made of steel and of a coat (14) that is made of a fibre composite (15), said coat enclosing the outside of the main body at least in some sections, wherein, for forming the fibre composite, a fibrous material is wound around the main body, wherein the fibrous material is impregnated with a resin before or after winding, wherein the wound and impregnated fibrous material is heated in order to form the fibre composite, wherein the method is carried out in situ on a built-in pressure pipe or pressure container, wherein the wound and impregnated fibrous material is heated to up to 700° C.

Abstract: The invention relates to a component connection comprising at least two CFC components that are interconnected by means of a force-fitting or form-fitting connection, the component connection being secured by means of a discrete material-bonded connection (68) in a connecting zone (69) formed between the components.

Abstract: The invention relates to a component connection comprising at least two CFC components that are interconnected in a force-fitting manner by means of a connecting system exclusively having connecting elements consisting of CFC or graphite, the component connection having a spring element (42) consisting of a CFC material.

Abstract: The invention relates to a circulation device (20) for circulating an ambient atmosphere and to a method for producing a circulation device, the circulation device having a shaft (21), a blade carrier (22) connected to the shaft and a plurality of blades (23) arranged on the blade carrier, both the blade carrier and the blades being realized as CFC components and being interconnected in a force-fitting manner by means of a connecting system exclusively having connecting elements consisting of CFC or graphite and the connecting system having a spring element to consisting of a CFC material.

Abstract: The present invention relates to a genetically modified yeast cell comprising: —at least one recombinant promoter operably linked to at least one gene encoding a polypeptide or protein supporting the biosynthesis of polypeptides or proteins within said cell, said at least one gene being located at the native genomic locus of the genetically unmodified wild-type yeast cell, wherein the naturally occurring promoter of the at least one gene encoding the biosynthesis supporting polypeptide or protein is inactivated by at least one mutation within said naturally occurring promoter and, —a secretion cassette comprising a recombinant nucleic acid molecule encoding a protein or polypeptide of interest and a method for producing a recombinant protein or polypeptide of interest using such a cell.

Abstract: A portable personalized tracker card is provided. The tracker card may be a patient tracker card. The tracker card includes a control unit, a memory for storing personal data, an energy supply unit and an electrochromic display for displaying the personal data.

Abstract: R-hydroxynitrile lyases having an improved substrate acceptance, increased activity and increased selectivity, in which there is replacement in the amino acid sequence of R-hydroxynitrile lyases from the Rosaceae family either a) of the amino acid residue which corresponds to position 360 of the mature PaHNL5 protein by another apolar amino acid or a neutral amino acid and/or b) of the amino acid residue which corresponds to position 225 of the mature PaHNL5 protein by another polar amino acid, it also being possible where appropriate for 1 to 20 further residues in the active center or in the hydrophobic channel leading to the active center to be replaced.

Abstract: The invention relates to R-hydroxynitrillyases from the family of Rosaceae that are characterized by an improved substrate tolerance and increased stability. In the active center of the R-hydroxynitrillyases either a) an alanine group is substituted by glycine, valine, leucine, isoleucine, or phenylalanine or b) a phenylalanine group is substituted by alanine, glycine valine, leucine or isoleucine, or c) a leucine group is substituted by alanine, glycine, valine, isoleucine or phenylalanine, or d) an isoleucine group is substituted by alanine, glycine, valine, leucine or phenylalanine. The invention also relates to the use of these lyases in the production of enantiomer-pure R- or S-cyanohydrines.

Abstract: The invention related to R-hydroxynitrillyases from the family of Rosaceae that are characterized by an improved substrate tolerance and increased stability. In the active center of the R-hydroxynitrillyases either a) an alanine group is substituted by glycine, valine, leucine, isoleucine, or phenylalanine or b) a phenylalanine group is substituted by alanine, glycine valine, leucine or isoleucine, or c) a leucine group is substituted by alanine, glycine, valine, isoleucine or phenylalanine, or d) an isoleucine group is substituted by alanine, glycine, valine, leucine or phenylalanine. The invention also relates to the use of these lyases in the production of enantiomer-pure R- or S-cyanohydrines.