Abstract: The present invention relates to an immunodeficient non-human animal where endogenous drug metabolising enzymes and transcription factors are substantially inactivated. In some aspects of the invention, the animal expresses human drug metabolising enzymes and associated transcription factors. There is also provided related methods of generating the animal of the invention. Additionally, there is provided methods of performing preclinical drug studies using the animal of the invention.

Abstract: The invention relates to an eyeglass joint for an eyeglass frame with a first joint part assigned to a rim of the eyeglass frame, and a second joint part assigned to an eyeglass temple of the eyeglass frame, wherein the joint parts are movably connected to each other by means of at least one spring element attached to both joint parts, wherein the spring element preferably has a closed annular shape and/or is rubber-elastic. Furthermore, the invention relates to a joint set, an eyeglass frame, an eyeglass frame set, and the use of a spring element.

Abstract: An insulating device for a thermal and/or acoustic insulation of an exhaust system of a vehicle has a first half shell including at least a first connection rim and a second half shell including at least a second connection rim, the first half shell and the second half shell being connected by a welded joint at the connection rims. The connection rims are reshaped into a multiple fold. Further disclosed are a vehicle exhaust system having an exhaust gas-carrying duct and an insulating device circumferentially surrounding the duct, as well as a method for producing an insulating device for a thermal and/or acoustic insulation of an exhaust system of a vehicle.

Abstract: The invention relates to an eyeglass joint for an eyeglass frame with a first joint part assigned to a rim of the eyeglass frame, and a second joint part assigned to an eyeglass temple of the eyeglass frame, wherein the joint parts are movably connected to each other by means of at least one spring element attached to both joint parts, wherein the spring element preferably has a closed annular shape and/or is rubber-elastic. Furthermore, the invention relates to a joint set, an eyeglass frame, an eyeglass frame set, and the use of a spring element.

Abstract: A method of manufacturing a cylindrical housing of an exhaust-gas treatment unit for vehicles includes providing a flat sheet metal part having at least one embossing, and round bending the sheet-metal part in a round bending tool by displacing the sheet metal part between rolls such that the sheet metal part obtains a cylindrical shape having a longitudinal direction parallel to roll axes of the rolls. At least one elastic roll is used such that the embossing of the sheet metal part is maintained during round bending. The longitudinal edges of the cylindrical sheet metal part are then connected to form a tube. A method of manufacturing an exhaust-gas treatment unit is furthermore shown.

Abstract: A method of manufacturing a cylindrical housing of an exhaust-gas treatment unit for vehicles includes providing a flat sheet metal part having at least one embossing, and round bending the sheet-metal part in a round bending tool by displacing the sheet metal part between rolls such that the sheet metal part obtains a cylindrical shape having a longitudinal direction parallel to roll axes of the rolls. At least one elastic roll is used such that the embossing of the sheet metal part is maintained during round bending. The longitudinal edges of the cylindrical sheet metal part are then connected to form a tube. A method of manufacturing an exhaust-gas treatment unit is furthermore shown.

Abstract: The application comprises a device for protecting against water ingress and fire penetration into interspaces and into cavities through expansion joints in structures, cable ducts and cable lead-throughs which are occupied by cables and/or pipes, and, depending on the application, serves as a fire protection or leakage protection device in landfills, tank systems and transport and/or safety containers in the sea sector. The device comprises a flat-tube cushion which is fixed in terms of length and width and which is equipped on the outer sides with a swellable nonwoven sealing strip. In the interior, the leakage or protective flat-tube cushion is provided with at least one swellable nonwoven sealing strip which has high-tensile-strength closures on the longitudinal side and the transverse side and is filled or evacuated via at least one plastic-coated metal compressed-air valve with a valve extension, and, depending on the application, can be equipped with a radio monitoring or control system.

Abstract: An insulating device for a thermal and/or acoustic insulation of an exhaust system of a vehicle has a first half shell including at least a first connection rim and a second half shell including at least a second connection rim, the first half shell and the second half shell being connected by a welded joint at the connection rims. The connection rims are reshaped into a multiple fold. Further disclosed are a vehicle exhaust system having an exhaust gas-carrying duct and an insulating device circumferentially surrounding the duct, as well as a method for producing an insulating device for a thermal and/or acoustic insulation of an exhaust system of a vehicle.

Abstract: In a method for printing, print images can be stored in the printer controller as bitmaps made up of bitmap data arranged in rows and columns. A printing element of a print head may be associated with a respective column of the bitmap. The same bitmap data of the bitmap may be associated with the printing elements of the print heads that are situated in an overlap region. The printing elements in the overlap region can be activated such that a print dot associated with a bitmap datum may be printed both by a printing element of the one print head and by a printing element of the other print head.

Abstract: An error logging method for a coating plant is disclosed. The error logging method generally includes capturing an error during running of process data records for the coating plant, wherein the individual process data records are ordered according to the given time of operation of the coating plant and each of which contain various process data of the coating plant. The method may further include storage of the captured process data records, detection of a possible error condition of the coating plant, and/or production of an error code when detection of an error condition of the coating plant occurs. The various examples may also relate to storage of the error code in chronological order with the stored process data records.

Abstract: Apparatus and method for producing a spatial depth effect of an image information item present in a 2D image surface. The apparatus has a viewing bezel having an opening, wherein the viewing bezel has a boundary delimiting a viewing field and the opening forms the viewing field. In addition, the apparatus has a 2D image surface which is arranged at a distance behind the viewing bezel. With appropriate use of the apparatus, as viewed from a viewing position, the viewing bezel conceals the external boundary of the 2D image surface and, if appropriate, a frame element connected radially outwardly to the external boundary. The distance between the boundary of the viewing bezel delimiting the viewing field and the 2D image surface arranged behind it, is at least approximately constant.

Abstract: The present invention provides methods for enhancing the synthesis of isotope labelled native proteins in specific biological pathways for the purpose of protein quantification and qualification. The invention provides reference samples for use in various mass-spectrometry-based methods of protein analysis.

Abstract: The present invention relates to spectacles comprising a spectacle frame and a spectacle glass. The spectacle frame, in turn, comprises a frame which defines a receiving opening for the spectacle glass and essentially completely borders the spectacle glass. The spectacle glass is fixed in the receiving opening by means of a thread inserted between the frame defining the receiving opening and the edge of the spectacle glass.

Abstract: The present invention relates to an improved assay for identifying compounds that may be of use in conjunction with cancer chemotherapeutic agents and anti-proliferative agents, to improve efficacy of such agents and/or render effective compounds with relatively little therapeutic activity. There is also provided a class of compounds identified by said assay which may be used in a combination therapy, with current and novel agents, to treat cancers and other diseases associated with abnormal host cell proliferation, such as psoriasis.

Abstract: The invention relates to a thermal link (1) for electrical appliances, comprising an insulating part (10) with electrical terminals (11) and contact springs (12) for providing electrical contact between said terminals (11), a fusible material insert (15) that acts as the thermal trip element and a transmission pin (13), which is displaceably mounted in the insulting part (10), one end of which engaging with the fusible material insert (15) and the other end with the contact springs (12). Said link is characterised in that the fusible material insert (15) is situated in a casing (141) that is configured as one piece with the heat transfer plate (14).

Abstract: The present invention relates to spectacles comprising a spectacle frame and a spectacle glass. The spectacle frame, in turn, comprises a frame which defines a receiving opening for the spectacle glass and essentially completely borders the spectacle glass. The spectacle glass is fixed in the receiving opening by means of a thread inserted between the frame defining the receiving opening and the edge of the spectacle glass.

Abstract: In a fixer unit system and method to detect a fire in a fixer unit of an electrographic image generation device, at least one portion of a fixer region of the fixing unit is monitored with a photoelectric sensor arranged adjacent to a substrate material having a toner image to be fixed, at least one portion of radiation generated by at least one heat radiator of the fixer unit is not detected by the photoelectric sensor by not passing said at least one portion of the radiation generated by the at least one heat radiator through to the photoelectric sensor by use of an optical filter associated with the photoelectric sensor. An error signal is output when a fire in the fixer region is detected with the photoelectric sensor.

Abstract: An error logging method for a coating plant is disclosed. The error logging method generally includes capturing an error during running of process data records for the coating plant, wherein the individual process data records are ordered according to the given time of operation of the coating plant and each of which contain various process data of the coating plant. The method may further include storage of the captured process data records, detection of a possible error condition of the coating plant, and/or production of an error code when detection of an error condition of the coating plant occurs. The various examples may also relate to storage of the error code in chronological order with the stored process data records.

Abstract: The present invention relates to an improved assay for identifying compounds that may be of use in conjunction with cancer chemotherapeutic agents and anti-proliferative agents, to improve efficacy of such agents and/or render effective compounds with relatively little therapeutic activity. There is also provided a class of compounds of formula (I) and retinoids identified by said assay which may be used in a combination therapy, with current and novel agents, to treat cancers and other diseases associated with abnormal host cell proliferation, such as psoriasis.