Abstract: An insulating device for a thermal and/or acoustic insulation of an exhaust system of a vehicle has a first half shell including at least a first connection rim and a second half shell including at least a second connection rim, the first half shell and the second half shell being connected by a welded joint at the connection rims. The connection rims are reshaped into a multiple fold. Further disclosed are a vehicle exhaust system having an exhaust gas-carrying duct and an insulating device circumferentially surrounding the duct, as well as a method for producing an insulating device for a thermal and/or acoustic insulation of an exhaust system of a vehicle.

Abstract: The invention relates to an eyeglass joint for an eyeglass frame with a first joint part assigned to a rim of the eyeglass frame, and a second joint part assigned to an eyeglass temple of the eyeglass frame, wherein the joint parts are movably connected to each other by means of at least one spring element attached to both joint parts, wherein the spring element preferably has a closed annular shape and/or is rubber-elastic. Furthermore, the invention relates to a joint set, an eyeglass frame, an eyeglass frame set, and the use of a spring element.

Abstract: A method of manufacturing a cylindrical housing of an exhaust-gas treatment unit for vehicles includes providing a flat sheet metal part having at least one embossing, and round bending the sheet-metal part in a round bending tool by displacing the sheet metal part between rolls such that the sheet metal part obtains a cylindrical shape having a longitudinal direction parallel to roll axes of the rolls. At least one elastic roll is used such that the embossing of the sheet metal part is maintained during round bending. The longitudinal edges of the cylindrical sheet metal part are then connected to form a tube. A method of manufacturing an exhaust-gas treatment unit is furthermore shown.

Abstract: A method of manufacturing a cylindrical housing of an exhaust-gas treatment unit for vehicles includes providing a flat sheet metal part having at least one embossing, and round bending the sheet-metal part in a round bending tool by displacing the sheet metal part between rolls such that the sheet metal part obtains a cylindrical shape having a longitudinal direction parallel to roll axes of the rolls. At least one elastic roll is used such that the embossing of the sheet metal part is maintained during round bending. The longitudinal edges of the cylindrical sheet metal part are then connected to form a tube. A method of manufacturing an exhaust-gas treatment unit is furthermore shown.

Abstract: The application comprises a device for protecting against water ingress and fire penetration into interspaces and into cavities through expansion joints in structures, cable ducts and cable lead-throughs which are occupied by cables and/or pipes, and, depending on the application, serves as a fire protection or leakage protection device in landfills, tank systems and transport and/or safety containers in the sea sector. The device comprises a flat-tube cushion which is fixed in terms of length and width and which is equipped on the outer sides with a swellable nonwoven sealing strip. In the interior, the leakage or protective flat-tube cushion is provided with at least one swellable nonwoven sealing strip which has high-tensile-strength closures on the longitudinal side and the transverse side and is filled or evacuated via at least one plastic-coated metal compressed-air valve with a valve extension, and, depending on the application, can be equipped with a radio monitoring or control system.

Abstract: An insulating device for a thermal and/or acoustic insulation of an exhaust system of a vehicle has a first half shell including at least a first connection rim and a second half shell including at least a second connection rim, the first half shell and the second half shell being connected by a welded joint at the connection rims. The connection rims are reshaped into a multiple fold. Further disclosed are a vehicle exhaust system having an exhaust gas-carrying duct and an insulating device circumferentially surrounding the duct, as well as a method for producing an insulating device for a thermal and/or acoustic insulation of an exhaust system of a vehicle.

Abstract: In a method for printing, print images can be stored in the printer controller as bitmaps made up of bitmap data arranged in rows and columns. A printing element of a print head may be associated with a respective column of the bitmap. The same bitmap data of the bitmap may be associated with the printing elements of the print heads that are situated in an overlap region. The printing elements in the overlap region can be activated such that a print dot associated with a bitmap datum may be printed both by a printing element of the one print head and by a printing element of the other print head.

Abstract: An error logging method for a coating plant is disclosed. The error logging method generally includes capturing an error during running of process data records for the coating plant, wherein the individual process data records are ordered according to the given time of operation of the coating plant and each of which contain various process data of the coating plant. The method may further include storage of the captured process data records, detection of a possible error condition of the coating plant, and/or production of an error code when detection of an error condition of the coating plant occurs. The various examples may also relate to storage of the error code in chronological order with the stored process data records.

Abstract: Apparatus and method for producing a spatial depth effect of an image information item present in a 2D image surface. The apparatus has a viewing bezel having an opening, wherein the viewing bezel has a boundary delimiting a viewing field and the opening forms the viewing field. In addition, the apparatus has a 2D image surface which is arranged at a distance behind the viewing bezel. With appropriate use of the apparatus, as viewed from a viewing position, the viewing bezel conceals the external boundary of the 2D image surface and, if appropriate, a frame element connected radially outwardly to the external boundary. The distance between the boundary of the viewing bezel delimiting the viewing field and the 2D image surface arranged behind it, is at least approximately constant.

Abstract: A bacterial cell containing a functional cytochrome P450 monooxygenase system, said cell comprising a genetic construct capable of expressing a cytochrome P450 and a genetic construct capable of expressing, separately from said cytochrome P450, a cytochrome P450 reductase wherein the N-terminus of the cytochrome P450 and the N-terminus of the cytochrome P450 reductase are each adapted to allow functional coupling of said cytochrome P450 and said cytochrome P450 reductase within said cell. A bacterial cell containing a cytochrome P450 comprising a genetic construct encoding, and capable of expressing, said cytochrome P450 wherein the cytochrome P450 comprises an N-terminal portion which directs the cytochrome P450 to a cellular compartment of membrane of the bacterial cell. The bacterial cells are useful as, for example, bioreactors, in drug testing and mutagenicity testing and as a source of cytochrome P450.

Abstract: The present invention provides methods for enhancing the synthesis of isotope labelled native proteins in specific biological pathways for the purpose of protein quantification and qualification. The invention provides reference samples for use in various mass-spectrometry-based methods of protein analysis.

Abstract: The invention relates to the generation of mouse models of drug metabolism in which clusters of genes that are involved in drug metabolism have been knocked out. The development of new drugs and chemicals for therapeutic use or for other purposes is extremely complex. Of particular importance is the understanding of how these chemical agents are handled in the body, whether they have appropriate pharmacokinetics and whether, as a consequence of metabolism, any safety issues arise. Many of the proteins that are involved in the metabolism, disposition and elimination of drugs are members of multigene families that exhibit very marked species differences in gene number, function and regulation. For these reasons, experiments carried out in laboratory animals to establish routes of metabolism or toxicity can be severely compromised and, as a consequence, do not faithfully represent the human situation.

Abstract: The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans. One aspect of the invention relates to the use of a human DNA sequence comprising at least part of introns 6 and/or 7 of the human PXR gene.

Abstract: There is provided compositions comprising perfluorooctanoic acid (PFOA) or a salt, derivative or variant thereof. There is also provided uses, methods therapeutic systems and combination therapies relating to PFOA.

Abstract: The present invention relates to spectacles comprising a spectacle frame and a spectacle glass. The spectacle frame, in turn, comprises a frame which defines a receiving opening for the spectacle glass and essentially completely borders the spectacle glass. The spectacle glass is fixed in the receiving opening by means of a thread inserted between the frame defining the receiving opening and the edge of the spectacle glass.

Abstract: The present invention relates to an improved assay for identifying compounds that may be of use in conjunction with cancer chemotherapeutic agents and anti-proliferative agents, to improve efficacy of such agents and/or render effective compounds with relatively little therapeutic activity. There is also provided a class of compounds identified by said assay which may be used in a combination therapy, with current and novel agents, to treat cancers and other diseases associated with abnormal host cell proliferation, such as psoriasis.

Abstract: The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans.

Abstract: The invention relates to a thermal link (1) for electrical appliances, comprising an insulating part (10) with electrical terminals (11) and contact springs (12) for providing electrical contact between said terminals (11), a fusible material insert (15) that acts as the thermal trip element and a transmission pin (13), which is displaceably mounted in the insulting part (10), one end of which engaging with the fusible material insert (15) and the other end with the contact springs (12). Said link is characterised in that the fusible material insert (15) is situated in a casing (141) that is configured as one piece with the heat transfer plate (14).

Abstract: The invention relates to a method for screening for the effects of non-genotoxic carcinogens in an animal model. The invention also relates to animal models that are suitable for use in such a method, and cell lines derived from these animals for in vitro screening purposes. More specifically, the invention relates to a transgenic rodent animal which has been humanised for the nuclear transcription factors CAR, PXR and PPAR?, and in which the endogenous equivalent genes have been rendered inoperable.