Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.

Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.

Abstract: Provided is a method for obtaining high-yield, stable expression cell clones from myeloma cell lines in a protein-free culture medium. The method is used for industrial production of a recombinant antibody, and includes three stage: (1) adapting to a protein-free culture medium, statically culturing cells at a low density, and gradually reducing a fat-rich supplement to a chemical culture medium; (2) adapting to a protein-free culture medium; culturing cells at a high density, and using a perfusion fermentation system in a laboratory scale; and (3) screening high-yield, stable expression cell clones from the cells after fermentation ends. The cell clone may be used to produce a humanized anti-NeuGcGM3 14F7 recombinant antibody.

Abstract: Methods, systems and computer program products for determining and providing an availability status of an individual in a messaging application are provided. Aspects include obtaining historical usage data for the individual for the messaging application, obtaining location data, activity data and calendar data for the individual, and calculating a current availability status for the individual based on the historical usage data, the location data, the activity data and the calendar data. Aspects also include calculating a predicted future availability status for the individual based on the historical usage data, the location data, the activity data and the calendar data and providing the current availability status and the predicted future availability status to other users of the messaging application.

Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.

Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.

Abstract: Methods, systems and computer program products for determining and providing an availability status of an individual in a messaging application are provided. Aspects include obtaining historical usage data for the individual for the messaging application, obtaining location data, activity data and calendar data for the individual, and calculating a current availability status for the individual based on the historical usage data, the location data, the activity data and the calendar data. Aspects also include calculating a predicted future availability status for the individual based on the historical usage data, the location data, the activity data and the calendar data and providing the current availability status and the predicted future availability status to other users of the messaging application.

Abstract: A solid and liquid dietary dispensing system simultaneously stores and dispenses liquid and solid edible substances, while being manipulated with one hand. The system comprises a flattened tubular container defined by a container sidewall that forms a container cavity, containing a liquid edible substance. The container has a base end and a dispense end with a neck having a neck opening. Depressing the container forces the liquid edible substance through the neck opening. A cap detachably attaches to the container. The cap is defined by a continuous cap sidewall that forms a cap cavity. The cap has a discharge end and a mount end. The mount end comprises a channel that detachably mates with the neck of the container. The container cavity and the cap cavity are in fluid communication. Barriers segregates the cap cavity into compartments. A gate at discharge end of the cap regulates access to cap cavity.

Abstract: A toy and method of operation provides: a marking instrument for marking on a substrate, a container for containing candy or medicine or a toy; and a spinning toy for entertainment. The toy comprises a marking device defined by a mark end and a cap end, with the cap end having a circular flange. The toy also comprises a dispenser for containing candy, medicine, or a toy. A toy portion separates into a first toy member, a central spinner, and a second toy member. A cord extends between the first and second toy members, passing through a channel in central spinner. Twisting the cord in a first direction generates torque, causing the central spinner to be rotatably carried towards the first toy member. Twisting the cord in a second direction releases momentum from the generated torque, rotatably carrying the central spinner towards the second toy member.

Abstract: Provided is a method for obtaining high-yield, stable expression cell clones from myeloma cell lines in a protein-free culture medium. The method is used for industrial production of a recombinant antibody, and includes three stage: (1) adapting to a protein-free culture medium, statically culturing cells at a low density, and gradually reducing a fat-rich supplement to a chemical culture medium; (2) adapting to a protein-free culture medium; culturing cells at a high density, and using a perfusion fermentation system in a laboratory scale; and (3) screening high-yield, stable expression cell clones from the cells after fermentation ends. The cell clone may be used to produce a humanized anti-NeuGcGM3 14F7 recombinant antibody.

Abstract: An edible spinning device and method of operation provides: a spinning toy; a container; and an edible component for consumption. An outer sphere contains the candy and medicine. The outer sphere separates into a first sphere portion and a second sphere portion. An edible member having a pair of diametrically opposed depressions positions between the first sphere portion and the second sphere portion. A first cord extends along an axis between the first sphere portion and the edible member. A second cord extends along the axis between the second sphere portion and the edible member. Moving the first sphere portion away from the second sphere portion increases torque in the first and second cords to spin the edible member along the axis. Moving the first sphere portion towards the second sphere portion releases momentum from the generated torque to spin the edible member off-center from the axis.

Abstract: An edible spinning device and method of operation provides: a spinning toy; a container; and an edible component for consumption. An outer sphere contains the candy and medicine. The outer sphere separates into a first sphere portion and a second sphere portion. An edible member having a pair of diametrically opposed depressions positions between the first sphere portion and the second sphere portion. A first cord extends along an axis between the first sphere portion and the edible member. A second cord extends along the axis between the second sphere portion and the edible member. Moving the first sphere portion away from the second sphere portion increases torque in the first and second cords to spin the edible member along the axis. Moving the first sphere portion towards the second sphere portion releases momentum from the generated torque to spin the edible member off-center from the axis.

Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.

Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.

Abstract: A computer-implemented method of generating a graphical user interface (GUI) element for chart navigation and selection is provided. The computer-implemented method includes determining that a chart including chart elements that are expandable is to be displayed on a first portion of a touchscreen, generating the GUI element including GUI element sections respectively corresponding to each of the chart elements, displaying the chart and the GUI element in the first and a second portion of the touchscreen, respectively, and linking the GUI element with the chart such that first and second user actions relative to the GUI element and one of the GUI element sections, respectively, cause a corresponding navigation modification of the chart and a corresponding expansion of the corresponding one of the chart elements, respectively.

Abstract: A computer-implemented method of generating a graphical user interface (GUI) element for chart navigation and selection is provided. The computer-implemented method includes determining that a chart including chart elements that are expandable is to be displayed on a first portion of a touchscreen, generating the GUI element including GUI element sections respectively corresponding to each of the chart elements, displaying the chart and the GUI element in the first and a second portion of the touchscreen, respectively, and linking the GUI element with the chart such that first and second user actions relative to the GUI element and one of the GUI element sections, respectively, cause a corresponding navigation modification of the chart and a corresponding expansion of the corresponding one of the chart elements, respectively.

Abstract: The present invention is related to the branch of immunology and particularly with the generation of pharmaceutical compositions containing a humanized monoclonal antibody recognizing the leukocyte differentiation antigen CD6. Accordingly with that statement, the purpose of this invention is to provide pharmaceutical compositions which contain a humanized anti-monoclonal antibody for the diagnosis and treatment of Autoimmune Diseases, particularly the Rheumatoid Arthritis.

Abstract: In one embodiment, a computer-implemented method includes writing, into a tree content column of a tree table, content for a plurality of rows of the tree table. The content spans multiple hierarchical levels, and the content in each of the rows is commonly aligned within the tree content column. A level-indicating icon is associated with each of the hierarchical levels of the tree table. A first level-indicating icon for a first hierarchical level of the tree table is positioned in two or more distinct rows of the tree table having content in the first hierarchical level, and a second level-indicating icon for a second hierarchical level of the tree table is positioned in at least one row of the tree table having content in the second hierarchical level. The tree table is rendered by a computer processor.

Abstract: The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.

Abstract: A technique is provided for a graphical user interface on a computer. The technique includes receiving messages individually corresponding to resources being monitored, displaying rows in a table, and generating bar graphs of the messages respectively corresponding to the resources in the rows. Each of the bar graphs displays a color coded scheme to visually distinguish severity of the messages in each of the rows for the resources. The bar graphs display the severity of the messages for one resource per the given row without requiring user intervention to view severities of the messages displayed by the color coded scheme, without requiring user intervention to view a total number of messages for the given row, while maintaining a same row height regardless of the total number of messages for the given row, and without changing a table size including a table height and a table width of the table.