Abstract: The present invention provides a miniaturized integrated nucleic acid diagnostic device and system.

Abstract: A transdermal delivery member having a plurality of microprojections adapted to pierce the stratum corneum of a subject, each of the microprojection having a length less than 145 microns. In a preferred embodiment, each microprojection has a length in the range of approximately 50-145 microns.

Abstract: A transdermal agent delivery apparatus and system having a low infection potential comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the microprojection member includes a biocompatible coating having at least one biologically active agent and at least one antimicrobial agent disposed therein. In another embodiment, the microprojection member includes a hydrogel formulation having at least one biologically active agent and at least one antimicrobial agent. In yet another embodiment, the microprojection member includes a hydrogel formulation having at least one antimicrobial agent and a solid film having at least one biologically active agent.

Abstract: The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.

Abstract: The present invention provides a miniaturized integrated nucleic acid diagnostic device and system.

Abstract: A method and apparatus adapted to calibrate a test probe and oscilloscope system such that loading effects of the probe are substantially removed from the measurement.

Abstract: A method and apparatus adapted to calibrate a test probe and oscilloscope system such that loading effects of the probe are substantially removed from the measurement.

Abstract: The amplification of nucleic acids in a single phase can reliably provide products at relatively low cost and labor. A single-phase amplification can also increase the amount of nucleic acids while preserving the relative abundance of the individual nucleic acid species, or portions thereof. A single-phase amplified nucleic acid preparation may be analyzed in a gene expression monitoring system, preferably involving a nucleic acid probe array.

Abstract: The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.

Abstract: A method and apparatus for selectively providing bandwidth extension and channel matching for acquired signals under test (SUT). The method and apparatus includes a signal acquisition device for acquiring a signal under test (SUT) and generating therefrom a stream of acquired samples, where the signal acquisition device having associated with it a first bandwidth defining a nominal pass band. At least one digital filter imparts a gain equalization function to the acquired SUT samples within a spectral region including and extending beyond the nominal passband. A controller generates a display signal suitable for use by a display device, where the display signal representing waveform imagery associated with the gain equalized SUT.

Abstract: A method and apparatus for performing a plurality of small-volume reactions simultaneously with components in a bulk-phase medium are disclosed. The apparatus includes a device having an elongate or planar channel providing a plurality of discrete small-volume reaction regions within the channel, each communicating with supply and hold reservoirs from which material can be introduced into the regions, and to which material can be transferred from the reaction regions. A reaction-specific reagent is carried on a wall portion of each reaction region, or in a reservoir associated with a reaction region, for reacting in solution with one or more components in the bulk-phase medium, to effect a selected solution-phase reaction in each region or in a region-specific reservoir associated therewith.

Abstract: A microchannel apparatus and method for processing a sample are disclosed. The apparatus include a multisite reaction channel, one or more sample-preparation stations upstream of the reaction channel, for carrying out one or more selected sample-preparation steps effective to convert a sample to the bulk-phase medium, and one or more product-processing stations downstream of the reaction channel, for processing products generated in one or more of the reaction regions. Also included is structure for transferring solvent or solvent components between one of the sample-preparation stations and one or more selected reaction regions in the reaction channel, and between one or more selected reaction regions in the reaction channel and one of said product-processing stations, under the control of a control unit.

Abstract: A method and device for performing a plurality of small-volume reactions simultaneously are disclosed. The device includes an elongate or planar channel and a port for introducing such bulk-phase medium into the channel, a plurality of discrete small-volume reaction regions within the channel, and a reaction-specific reagent releasably carried on a wall portion of each reaction region. In carrying out the method of the invention, a bulk phase medium containing common reactants is added to the channel. Upon release of reaction-specific reagent from the wall portions of the reaction regions, a reagent-specific reaction can occur simultaneously in each region. The channel is dimensioned to substantially prevent convective fluid flow among the reaction regions during such reactions.

Abstract: A securement device for releasable attachment of a laptop computer or other article to a user's leg includes a table member and a pair of in-folding leg members, one each of which is attached for hinged movement relative to a corresponding side edge portion of the table member. Elastic webbing interconnects the free end portion of each leg member to a central portion on the underside of the table member. The securement device is centered on a user's leg and a pair of coacting straps are used to snugly encircle the user's leg to prevent pivotal movement of the securement device relative thereto and the leg members brace the table member to prevent displacement thereof as a result of ordinary unbalanced imposed forces. Elastic straps are provided whereby an article such as a laptop computer may be releasably attached to the supporting surface of the table member. The securement device allows a user of a laptop computer to stand and walk a few steps without displacing the laptop computer.

Abstract: A securement device for releasable attachment of a lapboard to a user's leg includes a table member and a pair of in-folding leg members, one each of which is attached for hinged movement relative to a corresponding side edge portion of the table member. Elastic webbing interconnects the free end portion of each leg member to a central portion on the underside of the table member. The securement device is centered on a user's leg with the leg members bracing the table member to prevent displacement thereof as a result of ordinary unbalanced imposed forces. When removed from a user's leg, the securement device folds to a compact storage position flush with the table member.

Abstract: A device for forming webs used for packaging containers with and without a pull-tab including, along the conveyance path of a web conveyed at a constant interval, a punch hole opening section for opening liquid-outlets, a strip tape pasting section which closes punch holes opened on a web with a wide strip tape or pastes narrow strip tape on a web having no punch holes, and a pull-tab pasting section having a pull-tab tape cutting and heating depositing member which cuts and heat-deposits a pull-tab on the web provided on the punch holes. Either a wide strip tape or a narrow strip tape is selectively supplied to the strip tape pasting section, and a pull-tab tape is supplied to the pull-tab pasting section. The punch hole opening section and the pull-tab pasting section can be inactivated. Thus, containers with and without a pull-tab can be manufactured by a single web forming device.