Patents by Inventor Rolf Angerbauer

Rolf Angerbauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6277833
    Abstract: Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments.
    Type: Grant
    Filed: September 24, 1998
    Date of Patent: August 21, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Angerbauer, Peter Fey, Walter Hübsch, Thomas Philipps, Hilmar Bischoff, Hans-Peter Krause, Jörg Petersen von Gehr, Delf Schmidt
  • Patent number: 6207671
    Abstract: The cycloalkano-pyridines are prepared by reacting corresponding cycloalkano-pyridine-aldehydes with suitable organometallic compounds or Wittig or Grignard reagents or reacting compounds of the cycloalkano-pyridine alcohols type with suitable bromine compounds, and optionally varying the functional groups accordingly. The cycloalkanopyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of hypertipoproteinaemia and arteriosclerosis.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: March 27, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Schmidt, Arndt Brandes, Rolf Angerbauer, Michael Lögers, Matthias Müller-Gliemann, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt, Joachim Schuhmacher, Henry Giera, Holger Paulsen, Paul Naab, Michael Conrad, Jürgen Stoltefuss
  • Patent number: 6127383
    Abstract: The 2-aryl-substituted pyridines are prepared by reacting pyridylaldehydes with organometallic compounds and then selectively reducing the products. The 2-aryl-substituted pyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis.
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: October 3, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Schmidt, Rolf Angerbauer, Arndt Brandes, Michael Logers, Matthias Muller-Gliemann, Hilmar Bischoff, Delf Schmidt, Stefan Wohlfeil
  • Patent number: 6121330
    Abstract: The novel 5-hydroxy-alkyl-substituted phenyls are prepared by either reacting the corresponding benzaldehydes with the Grignard compounds and subsequently reducing the other functional groups or by reducing the corresponding benzoic esters by customary methods to give the corresponding hydroxyl compounds. The 5-hydroxy-alkyl-substituted phenyls are suitable for use as active compounds in medicaments, in particular for the treatment of dyslipidaemia.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: September 19, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Matthias Muller-Gliemann, Rolf Angerbauer, Arndt Brandes, Michael Logers, Carsten Schmeck, Gunter Schmidt, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt
  • Patent number: 6069148
    Abstract: The cycloalkano-pyridines are prepared by reacting corresponding cycloalkano-pyridine-aldehydes with suitable organometallic compounds or Wittig or Grignard reagents or reacting compounds of the cycloalkano-pyridine alcohols type with suitable bromine compounds, and optionally varying the functional groups accordingly. The, cycloalkanopyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of hyperlipoproteinaemia and arteriosclerosis.
    Type: Grant
    Filed: July 8, 1997
    Date of Patent: May 30, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Schmidt, Arndt Brandes, Rolf Angerbauer, Michael Logers, Matthias Muller-Gliemann, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt, Joachim Schuhmacher, Henry Giera, Holger Paulsen, Paul Naab, Michael Conrad, Jurgen Stoltefuss
  • Patent number: 6063788
    Abstract: Bicyclic-fused pyridines are prepared by introducing the appropriate side chain by reaction of the corresponding aldehydes with the aid of Wittig or Grignard reagents. The bicyclic-fused pyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosi.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: May 16, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Arndt Brandes, Michael Logers, Gunter Schmidt, Rolf Angerbauer, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt, Joachim Schuhmacher
  • Patent number: 5932587
    Abstract: The heterocyclic-fused pyridines are prepared by reaction of the corresponding heterocyclic-fused pyridine aldehydes with appropriately substituted Grignard or Wittig reagents. The heterocyclic-fused pyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of dislipidaemia and arteriosclerosis.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: August 3, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Carsten Schmeck, Matthias Muller-Gliemann, Gunter Schmidt, Arndt Brandes, Rolf Angerbauer, Michael Logers, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt, Joachim Schuhmacher
  • Patent number: 5925645
    Abstract: The 2-aryl-substituted pyridines are prepared by reacting pyridylaldehydes with organometallic compounds and then selectively reducing the products. The 2-aryl-substituted pyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis.
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: July 20, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Schmidt, Rolf Angerbauer, Arndt Brandes, Michael Logers, Matthias Muller-Gliemann, Hilmar Bischoff, Delf Schmidt, Stefan Wohlfeil
  • Patent number: 5861385
    Abstract: Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments.
    Type: Grant
    Filed: August 8, 1995
    Date of Patent: January 19, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, deceased, Hilmar Bischoff, Hans-Peter Krause, Jorg Petersen von Gehr, Delf Schmidt
  • Patent number: 5849749
    Abstract: The 6-(hydroxymethyl-ethyl)pyridines are prepared by a process in which the 3-hydroxymethylpyridines which are hydroxyl-protected in the 6-position are oxidized to the 3-aldehyde, this is then converted into the corresponding oxoheptenoic acid derivative using a Wittig-Homer reaction, after this the oxo group is reduced to the hydroxyl group and then the isomers are separated by chromatography. The 6-(hydroxymethyl-ethyl)pyridines are suitable as active compounds in medicaments, in particular in medicaments having antiarteriosclerotic activity.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: December 15, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Fey, Rolf Angerbauer, Delf Schmidt, Hilmar Bischoff, Wolfgang Kanhai, Martin Radtke, Wolfgang Karl
  • Patent number: 5693650
    Abstract: 4-(Quinolin-2-yl-methoxy)-phenyl-acetic acid derivatives are prepared by reacting quinoline-methoxy-phenyl-acetic acids with the corresponding glycinol derivatives, if appropriate with activation of the carboxylic acid function. The new compounds are suitable as active compounds in medicaments, in particular in antiatherosclerotic medicaments.
    Type: Grant
    Filed: December 5, 1995
    Date of Patent: December 2, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Muller, Richard Connell, Siegfried Goldmann, Klaus-Helmut Mohrs, Rolf Angerbauer, Matthias Muller-Gliemann, Ulrich Niewohner, Rudi Grutzmann, Martin Beuck, Stefan Wohlfeil, Hilmar Bischoff, Dirk Denzer
  • Patent number: 5502199
    Abstract: Enantiomerically pure sodium 3R,5S-(+)-erythro-(E)-7- 4-(4-fluorophenyl)-2,6-diisopropyl-5-methoxy-meth yl-pyrid-3-yl!-3,5-dihydroxy-hept-6-enoate is prepared by initially cyclizing a corresponding racemic ester to give the racemic lactones and then separating the latter by chromatography on a chiral stationary phase. Cleavage of the enantiomerically pure lactones with the aid of a base yields the enantiomerically pure end products.
    Type: Grant
    Filed: March 17, 1994
    Date of Patent: March 26, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Angerbauer, Rolf Grosser, Werner Hinsken, Joachim Rehse
  • Patent number: 5502057
    Abstract: For the treatment of lipoproteinaemia and arteriosclerosis, the new disubstituted pyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heteroaryl,R.sup.2 is cycloalkyl or optionally substituted alkyl,R.sup.3 is hydrogen, cycloalkyl, or optionally substituted alkyl, aryl or heteroaryl,x is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--,A is ##STR2## R.sup.6 is hydrogen or alkyl, and R.sup.7 is hydrogen, alkyl, aralkyl or a cation.
    Type: Grant
    Filed: July 14, 1993
    Date of Patent: March 26, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Angerbauer, Peter Fey, Walter Hu/ bsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gu/ nter Thomas
  • Patent number: 5470982
    Abstract: For the treatment of lipoproteinaemia and arteriosclerosis, the new disubstituted pyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heteroaryl,R.sup.2 is cycloalkyl or optionally substituted alkyl,R.sup.3 is hydrogen, cycloalkyl, or optionally substituted alkyl, aryl or heteroaryl,X is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--,A is ##STR2## R.sup.6 is hydrogen or alkyl, and R.sup.7 is hydrogen, alkyl, aralkyl or a cation.
    Type: Grant
    Filed: September 24, 1992
    Date of Patent: November 28, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
  • Patent number: 5418243
    Abstract: Substituted 4-phenyl-pyridones and 4-phenyl-2-alkoxypyridines are prepared by reducing corresponding 4-phenyl-pyridone and 4-phenyl-2-alkoxypyridine derivatives. The substituted 4-phenyl-pyridones and 4-phenyl-2-alkoxypyridines can be employed as active compounds in medicaments, in particular for the treatment of hyperlipoproteinaemia.
    Type: Grant
    Filed: December 14, 1993
    Date of Patent: May 23, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Hans-Peter Krause, Jorg Peterson-von Gehr, Delf Schmidt
  • Patent number: 5409910
    Abstract: New substituted pyridines are prepared by reducing suitably substituted pyridine derivatives. The new substituted pyridines are suitable as active compounds in pharmaceuticals, in particular for the treatment of hyperlipoproteinaemia.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: April 25, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Hans-Peter Krause, Jorg P. von Gehr, Delf Schmidt
  • Patent number: 5401746
    Abstract: Novel compounds for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis of the formula ##STR1## in which A, B, D and E can have varied meanings,X is --CH.sub.2 --CH.sub.2 or --CH.dbd.CH--, andR is ##STR2## wherein R.sup.21 --denotes hydrogen or alkyl andR.sup.22 --denotes hydrogen,denotes alkyl, aryl or aralkyl, ordenotes a cation,and their oxidation products.
    Type: Grant
    Filed: July 20, 1992
    Date of Patent: March 28, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
  • Patent number: 5183897
    Abstract: Intermediate imino-substituted pyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl,R.sup.2 is optionally substituted aryl or alkyl, OH, alkoxy, aralkoxy, or optionally substituted aryloxy,R.sup.3 is isopropyl,R.sup.4 is isopropylX is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--,R is ##STR2## R.sup.6 is H or alkyl, and R.sup.7 is H, alkyl, phenylalkyl, aryl or a cation, and their salts.
    Type: Grant
    Filed: April 18, 1991
    Date of Patent: February 2, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt
  • Patent number: 5177080
    Abstract: Substituted pyridyl-dihydroxy-heptenoic acid of the formula ##STR1## and its salts, if desired in an isomeric form, have a superior inhibitory action on HMG-CoA reductase and thus bring about a surprisingly good lowering of the cholesterol content in the blood.
    Type: Grant
    Filed: November 26, 1991
    Date of Patent: January 5, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
  • Patent number: 5173495
    Abstract: For the treatment of lipoproteinaemia and arteriosclerosis, the polysubstituted pridines of the formula ##STR1## in which R.sup.1 is optionally substituted furyl or thienyl,R.sup.2 is cycloalkyl or optionally substituted alkyl,R.sup.3 is hydrogen, cycloalkyl, or optionally substituted alkyl, aryl or heteroaryl,X is --CH.dbd.CH--,A is ##STR2## R.sup.6 is hydrogen or alkyl, and R.sup.7 is hydrogen, alkyl, aralkyl or a cation.
    Type: Grant
    Filed: August 8, 1990
    Date of Patent: December 22, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas