Patents by Inventor Rolf Banholzer

Rolf Banholzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing new tiotropium salts, new tiotropium salts as such and pharmaceutical compositions thereof
    Patent number: 8686148
    Abstract: The invention relates to a process for preparing new tiotropium salts, these new tiotropium salts as such, pharmaceutical formulations containing them and their use for preparing a medicament for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: April 1, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Rolf Banholzer, Waldemar Pfrengle, Peter Sieger
  • Medicaments comprising steroids and a novel anticholinergic
    Patent number: 7851483
    Abstract: A pharmaceutical composition comprising: (a) a salt of formula 1 wherein: X? is an anion with a single negative charge; and (b) a steroid 2, processes for preparing such pharmaceutical composition, and their use in the treatment of respiratory complaints.
    Type: Grant
    Filed: April 20, 2006
    Date of Patent: December 14, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Helmut Meissner, Gerd Morschhaeuser, Michael P. Pieper, Gerald Pohl, Richard Reichl, Georg Speck, Christopher John Montague Meade, Michel Pairet
  • Anticholinergics which may be used as medicaments as well as processes for preparing them
    Patent number: 7569581
    Abstract: The present invention relates to new anticholinergics of general formula 1 wherein A, X?, and the groups R1, R2, R3, R4, R5, R6 and R7 may have the meanings given in the claims and in the specification, processes for preparing them and their use as pharmaceutical compositions.
    Type: Grant
    Filed: April 28, 2005
    Date of Patent: August 4, 2009
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Helmut Meissner, Gerd Morschhaeuser, Michael Paul Pieper, Gerald Pohl, Richard Reichl, Georg Speck, Rolf Banholzer
  • Medicaments comprising betamimetics and a novel anticholinergic
    Patent number: 7417051
    Abstract: A pharmaceutical composition comprising: (a) a salt of formula 1 wherein: X? is an anion with a single negative charge; and (b) a betamimetic 2, or a solvate or hydrate thereof, optionally in the form of the enantiomers, mixtures of the enantiomers, or in the form of the racemates thereof, processes for preparing them and their use in the treatment of respiratory complaints.
    Type: Grant
    Filed: March 24, 2003
    Date of Patent: August 26, 2008
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Helmut Meissner, Gerd Morschhaeuser, Michael P. Pieper, Gerald Pohl, Richard Reichl, Georg Speck, Christopher John Montague Meade, Michel Pairet, Ingo Konetzki
  • Industrial process for preparing tropenol
    Patent number: 7321039
    Abstract: The invention relates to a new industrially useable process for preparing tropenol, optionally in the form of the acid addition salts thereof.
    Type: Grant
    Filed: January 18, 2005
    Date of Patent: January 22, 2008
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Gisela Bodenbach, Andreas Mathes, Helmut Meissner, Peter Specht
  • Medicaments comprising steroids and a novel anticholinergic
    Publication number: 20060276441
    Abstract: A pharmaceutical composition comprising: (a) a salt of formula 1 wherein: X? is an anion with a single negative charge; and (b) a steroid 2, processes for preparing such pharmaceutical composition, and their use in the treatment of respiratory complaints.
    Type: Application
    Filed: April 20, 2006
    Publication date: December 7, 2006
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Helmut Meissner, Gerd Morschhaeuser, Michael Pieper, Gerald Pohl, Richard Reichl, Georg Speck, Christopher Meade, Michel Pairet
  • Medicaments comprising steroids and a novel anticholinergic
    Patent number: 7084153
    Abstract: A pharmaceutical composition comprising: (a) a salt of formula 1 ?wherein: X? is an anion with a single negative charge; and (b) a steroid 2, processes for preparing such pharmaceutical composition, and their use in the treatment of respiratory complaints.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: August 1, 2006
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Helmut Meissner, Gerd Morschhaeuser, Michael P. Pieper, Gerald Pohl, Richard Reichl, Georg Speck, Christopher John Montague Meade, Michel Pairet
  • Anticholinergics which may be used as medicaments as well as processes for preparing them
    Publication number: 20050197357
    Abstract: The present invention relates to new anticholinergics of general formula 1 wherein A, X?, and the groups R1, R2, R3, R4, R5, R6 and R7 may have the meanings given in the claims and in the specification, processes for preparing them and their use as pharmaceutical compositions.
    Type: Application
    Filed: April 28, 2005
    Publication date: September 8, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Helmut Meissner, Gerd Morschhaeuser, Michael Pieper, Gerald Pohl, Richard Reichl, Georg Speck, Rolf Banholzer
  • Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
    Patent number: 6908928
    Abstract: Crystalline monohydrate of (1?,2?,4?,5?,7?)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide (tiotropium bromide monohydrate), processes for the preparation thereof, pharmaceutical compositions thereof, and their use.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: June 21, 2005
    Assignee: BI Pharma KG.
    Inventors: Rolf Banholzer, Peter Sieger, Christian Kulinna, Michael Trunk, Manfred Graulich, Peter Specht, Helmut Meissner, Andreas Mathes
  • Process for preparing new tiotropium salts, new tiotropium salts as such and pharmaceutical compositions thereof
    Publication number: 20050131007
    Abstract: The invention relates to a process for preparing new tiotropium salts, these new tiotropium salts as such, pharmaceutical formulations containing them and their use for preparing a medicament for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.
    Type: Application
    Filed: October 29, 2004
    Publication date: June 16, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Rolf Banholzer, Waldemar Pfrengle, Peter Sieger
  • Industrial process for preparing tropenol
    Publication number: 20050124813
    Abstract: The invention relates to a new industrially useable process for preparing tropenol, optionally in the form of the acid addition salts thereof.
    Type: Application
    Filed: January 18, 2005
    Publication date: June 9, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Gisela Bodenbach, Andreas Mathes, Helmut Meissner, Peter Specht
  • Industrial process for preparing tropenol
    Patent number: 6891042
    Abstract: The invention relates to a new industrially useable process for preparing tropenol, optionally in the form of the acid addition salts thereof.
    Type: Grant
    Filed: January 26, 2004
    Date of Patent: May 10, 2005
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Gisela Bodenbach, Andreas Mathes, Helmut Meissner, Peter Specht
  • Novel tiotropium salts, process for the preparation and pharmaceutical compositions thereof
    Publication number: 20050096341
    Abstract: The invention relates to new tiotropium salts, processes for preparing them, pharmaceutical formulations containing them and their use for preparing a medicament for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.
    Type: Application
    Filed: October 29, 2004
    Publication date: May 5, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Rolf Banholzer, Waldemar Pfrengle, Peter Sieger
  • Powder formulations containing tiotropium suitable for inhalation
    Patent number: 6881422
    Abstract: A method of making a physically stable and homogenous powdered pharmaceutical composition comprising a tiotropium salt and a physiologically acceptable excipient, the method comprising: (a) suspending the tiotropium salt and the physiologically acceptable excipient in a suspending agent in which the tiotropium salt and the physiologically acceptable excipient are essentially insoluble to obtain a suspension; and (b) removing the suspending agent from the suspension of step (a) to obtain the pharmaceutical composition, the pharmaceutical composition itself, and method of treating respiratory diseases, especially chronic obstructive pulmonary disease and asthma, in a patient in need thereof by administering an effective amount of the pharmaceutical composition to the patient.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: April 19, 2005
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Manfred Graulich, Christian Kulinna, Andreas Mathes, Helmut Meissner, Peter Seiger, Peter Specht, Michael Josef Friedrich Trunk
  • Powder formulations containing tiotropium suitable for inhalation
    Publication number: 20050009857
    Abstract: A method of making a physically stable and homogenous powdered pharmaceutical composition comprising a tiotropium salt and a physiologically acceptable excipient, the method comprising: (a) suspending the tiotropium salt and the physiologically acceptable excipient in a suspending agent in which the tiotropium salt and the physiologically acceptable excipient are essentially insoluble to obtain a suspension; and (b) removing the suspending agent from the suspension of step (a) to obtain the pharmaceutical composition, the pharmaceutical composition itself, and method of treating respiratory diseases, especially chronic obstructive pulmonary disease and asthma, in a patient in need thereof by administering an effective amount of the pharmaceutical composition to the patient.
    Type: Application
    Filed: July 27, 2004
    Publication date: January 13, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Manfred Graulich, Christian Kulinna, Andreas Mathes, Helmut Meissner, Peter Sieger, Peter Specht, Michael Trunk
  • Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
    Patent number: 6777423
    Abstract: Crystalline monohydrate of (1&agr;,2&bgr;,4&bgr;,5&agr;,7&bgr;)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide (tiotropium bromide monohydrate), processes for the preparation thereof, pharmaceutical compositions thereof, and their use.
    Type: Grant
    Filed: January 30, 2003
    Date of Patent: August 17, 2004
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Rolf Banholzer, Peter Sieger, Christian Kulinna, Michael Trunk, Manfred Graulich, Peter Specht, Helmut Meissner, Andreas Mathes
  • Industrial process for preparing tropenol
    Publication number: 20040158069
    Abstract: The invention relates to a new industrially useable process for preparing tropenol, optionally in the form of the acid addition salts thereof.
    Type: Application
    Filed: January 26, 2004
    Publication date: August 12, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Gisela Bodenbach, Andreas Mathes, Helmut Meissner, Peter Specht
  • Industrial process for preparing tropenol
    Patent number: 6747153
    Abstract: The invention relates to a new industrially useable process for preparing tropenol, optionally in the form of the acid addition salts thereof.
    Type: Grant
    Filed: May 29, 2003
    Date of Patent: June 8, 2004
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Gisela Bodenbach, Andreas Mathes, Helmut Meissner, Peter Specht
  • Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
    Publication number: 20040087793
    Abstract: Crystalline monohydrate of (1&agr;,2&bgr;,4&bgr;,5&agr;,7&bgr;)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide (tiotropium bromide monohydrate), processes for the preparation thereof, pharmaceutical compositions thereof, and their use.
    Type: Application
    Filed: October 23, 2003
    Publication date: May 6, 2004
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Rolf Banholzer, Peter Sieger, Christian Kulinna, Michael Trunk, Manfred Graulich, Peter Specht, Helmut Meissner, Andreas Mathes
  • Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
    Patent number: RE39820
    Abstract: Compounds of the formula of which, in exemplary compounds, the thienyl group is attached via the 2-position and; (a) A is 3?-(6?, 7?-epoxy)-tropanyl methobromide and R1 is 2-thienyl; (b) A is 3?-(6, 7dehydro)-tropanyl methobromide and R1 is 2-thienyl; (c) A is 3?-tropanyl methobromide and R1 is 2-thienyl; and, (d) A is 3?-(N-isopropyl)-nortropanyl methobromide and R1 is cyclopentyl. There are anticholinergics. Administered by inhalation, they are useful for the treatment of chronic obstructive bronchitis or slight to moderately severe asthma. Administered by the intravenous or oral routes, they are useful for the treatment of vagally induced sinus bradycardia.
    Type: Grant
    Filed: October 18, 2005
    Date of Patent: September 4, 2007
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Rudolf Bauer, Richard Reichl