Patents by Inventor Rolf Berge

Rolf Berge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fatty analogues for the treatment of obesity, hypertension and fatty liver
    Patent number: 6441036
    Abstract: The present invention relates to novel fatty acid analogous of the general forumla I: CH3—[CH2]m—[xi—CH2]n—COOR, as defined in the specification, which can be used for the treatment and/or prevention of obesity, fatty liver and hypertension. Further, the invention relates to a nutritional composition comprising such fatty acid analogues, and a method for reducing the total weight, or the amount of adipose tissue in an animal. The invention also relates to a method for improving the quality of product such as meat, milk and eggs.
    Type: Grant
    Filed: January 27, 2001
    Date of Patent: August 27, 2002
    Assignee: Thia Medica AS
    Inventor: Rolf Berge
  • Fatty acid analogues for the treatment of primary and secondary restenosis
    Patent number: 6417232
    Abstract: The present invention relates to novel fatty acid analogues of the general formula (I): CH3—[CH2]m—[Xi—CH2]n—COOR, wherein n is an integer from 1 to 12, and wherein m is an integer from 0 to 23, and wherein i is an odd number which indicates the position relative to COOR, and wherein Xi independent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and wherein R represents hydrogen or C1-C4 alkyl, with the proviso that at least one of the Xi is not CH2, or a salt, prodrug or complex thereof, for the preparation of a pharmaceutical composition for the treatment and/or prevention of primary and/or secondary stenosis. Further the present invention relates to the use of said compounds for the prevention and/or treatment of a disease caused by procedural vascular trauma and/or pathological proliferation of smooth muscle cells, and/or an increased level of plasma homocysteine.
    Type: Grant
    Filed: January 8, 2001
    Date of Patent: July 9, 2002
    Assignee: Thia Medica AS
    Inventor: Rolf Berge
  • Fatty analogues for the treatment of diabetes
    Patent number: 6365628
    Abstract: The present invention relates to novel fatty acid analogues of the general formula (I): CH3—[CH2]m—[xi—CH2]n—COOR, as defined in the specification, which can be used for the treatment and/or prevention of diabetes. Further, the invention relates to a nutritional composition comprising such fatty acid analogues.
    Type: Grant
    Filed: January 8, 2001
    Date of Patent: April 2, 2002
    Assignee: Thia Medica AS
    Inventor: Rolf Berge
  • Non-.beta.-oxidizable fatty acid analogues, their uses as therapeutic active medicaments
    Patent number: 6046237
    Abstract: There are disclosed compounds of the general formula (I): alkyl-X-CH.sub.2 COOR wherein alkyl represents a saturated or unsaturated hydrocarbon of 8-26 carbon atoms, X represents a sulfur atom or a selenium atom and R is hydrogen or C.sub.1 -C.sub.4 alkyl. Said compounds are used for the manufacturing of medicaments for the treatment of hyperlipidemic conditions, (arteriosclerotic disease), coronary artery disease and for reducing the concentration of lipids in blood of mammals, for inhibiting oxidative modification of LDL, and for reducing proliferation of cancer cells. Methods for preparing the compounds are also disclosed.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: April 4, 2000
    Inventors: Rolf Berge, Jon Songstad