Patents by Inventor Rolf Burghaus

Rolf Burghaus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for identifying predictive biomarkers from patient data
    Patent number: 8355874
    Abstract: The invention relates to a method for developing a biomarker for the prognosis of the result of a therapeutical treatment based on data obtained in clinical studies, data remaining unchanged by therapy being subdivided into diagnostic and genomic parameters and the marker being defined by a combination of parameters. The method according to the invention is characterized by specifying the maximum number of parameters for defining the marker and thus the maximum complexity of the system from the beginning and by carrying out the search for defining parameters by sequential combination of clinical parameters (=z parameters) and/or genomic parameters (=x parameters).
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: January 15, 2013
    Assignee: Bayer Technology Services GmbH
    Inventors: Andreas Schuppert, Rolf Burghaus, Christian Von Törne, Stephan Schwers, Udo Stropp, Harald Kallabis
  • Method for the Prediction of Adverse Drug Responses to Stains
    Publication number: 20090208945
    Abstract: The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy. Still further the invention provides polymorphic sequences and other genes. The present invention further relates to isolated polynucleotides encoding a SADR gene polypeptide useful in methods to identify therapeutic agents and useful for preparation of a medicament to treat statin induced adverse drug reactions (SADR), the polynucleotide is selected from the group comprising: SEQ ID 1-35 with allelic variation as indicated in the sequences section contained in a functional surrounding like full length cDNA for SADR gene polypeptide and with or without the SADR gene promoter sequence.
    Type: Application
    Filed: December 19, 2006
    Publication date: August 20, 2009
    Applicant: SIEMENS MEDICAL SOLUTIONS DIAGNOSTICS GMBH
    Inventors: Stephan Schwers, Udo Stropp, Harald Kallabis, Andreas Schuppert, Rolf Burghaus, Christian Von Torne, Gerd Schmitz
  • METHOD FOR IDENTIFYING PREDICTIVE BIOMARKERS FROM PATIENT DATA
    Publication number: 20090093689
    Abstract: The invention relates to a method for developing a biomarker for the prognosis of the result of a therapeutical treatment based on data obtained in clinical studies, data remaining unchanged by therapy being subdivided into diagnostic and genomic parameters and the marker being defined by a combination of parameters. The method according to the invention is characterized by specifying the maximum number of parameters for defining the marker and thus the maximum complexity of the system from the beginning and by carrying out the search for defining parameters by sequential combination of clinical parameters (=z parameters) and/or genomic parameters (=x parameters).
    Type: Application
    Filed: December 11, 2006
    Publication date: April 9, 2009
    Applicant: BAYER TECHNOLOGY SERVICES GMBH
    Inventors: Andreas Schuppert, Rolf Burghaus, Christian Von Torne, Stephan Schwers, Udo Stropp, Harald Kallabis
  • Method and system for the automatic design of experiments
    Patent number: 7079965
    Abstract: The invention relates to a method for the automatic design of experiments, having the following steps: inputting a similarity measure of two experiments, inputting a weighting measure for an individual experiment, determining a quality measure based on the similarity measure and the weighting measure, finding a number of experiments where the quality measure assumes an extreme value.
    Type: Grant
    Filed: February 25, 2003
    Date of Patent: July 18, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Burghaus, Georg Mogk, Thomas Mrziglod, Peter Hübl
  • Method and system for the automatic design of experiments
    Publication number: 20030237058
    Abstract: The invention relates to a method for the automatic design of experiments, having the following steps:
    Type: Application
    Filed: February 25, 2003
    Publication date: December 25, 2003
    Applicant: Bayer Aktiengesellschaft
    Inventors: Rolf Burghaus, Georg Mogk, Thomas Mrziglod, Peter Hubl