Abstract: A turbomachine structure having a first inner casing including a first and second flowpath oriented in opposing axial directions to one another; a second inner casing surrounding the first inner casing and including a third and fourth flowpath, wherein the third flowpath is fluidly connected to the first flowpath and the fourth flowpath is fluidly connected to the second flowpath; an extraction chamber defined between the first and second inner casings; a cooling passage defined between the first and second inner casings; a first extraction port fluidly connected to the cooling passage and to the first flowpath at a location in the first flowpath having a first pressure; and a second extraction port fluidly connected to the extraction chamber and to the second flowpath at a location in the second flowpath having a second pressure less than the first pressure.

Abstract: A turbomachine structure having a first inner casing including a first and second flowpath oriented in opposing axial directions to one another; a second inner casing surrounding the first inner casing and including a third and fourth flowpath, wherein the third flowpath is fluidly connected to the first flowpath and the fourth flowpath is fluidly connected to the second flowpath; an extraction chamber defined between the first and second inner casings; a cooling passage defined between the first and second inner casings; a first extraction port fluidly connected to the cooling passage and to the first flowpath at a location in the first flowpath having a first pressure; and a second extraction port fluidly connected to the extraction chamber and to the second flowpath at a location in the second flowpath having a second pressure less than the first pressure.

Abstract: A steam turbine is provided having a relief groove which is arranged in the region of the equalizing piston and extends in the circumferential direction of the rotor. The relief groove, with regard to an inlet passage, is arranged in the axial upstream direction so that it is arranged on the rotor outside a region in which the steam flow enters the bladed flow path via the inlet passage. The relief groove, with regard to the first blade row, is arranged in a region in which the greatest thermal stresses can arise in the rotor. As an option, the relief groove has a cover for reducing vortex flows, and also devices for reducing heating of the groove or devices for active cooling. The steam turbine allows an increased number of risk-free running up and running down operations of the steam turbine with minimum detriment to the turbine performance.

Abstract: The present application describes organic compounds of a general formula: and salts, and isomers thereof, wherein R, R2 and R3 are defined in the specification. The compounds are useful for treating a gram-negative bacterial infection.

Abstract: The present invention provides a compound formula I: (formula I) said compound is inhibitor of selective subset of kinases belonging to the AGC or calmodulin kinase family, such as for example MARK1/2/3, PKD-1/2/3, PKN-1/2, CDK-9, CaMKII, ROCK-I/II, inhibitors of histone deacetylase (HDAC) phosphorylation, or inhibitors of other kinases. Finally, the present invention also provides a pharmaceutical composition.

Abstract: A steam turbine is provided having a relief groove which is arranged in the region of the equalizing piston and extends in the circumferential direction of the rotor. The relief groove, with regard to an inlet passage, is arranged in the axial upstream direction so that it is arranged on the rotor outside a region in which the steam flow enters the bladed flow path via the inlet passage. The relief groove, with regard to the first blade row, is arranged in a region in which the greatest thermal stresses can arise in the rotor. As an option, the relief groove has a cover for reducing vortex flows, and also devices for reducing heating of the groove or devices for active cooling. The steam turbine allows an increased number of risk-free running up and running down operations of the steam turbine with minimum detriment to the turbine performance.

Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.

Abstract: The invention relates to the use of carboxyamine compounds and salts thereof in the treatment of HDAC dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases.