Patents by Inventor Rolf E. A. V. Axen
Rolf E. A. V. Axen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5124441Abstract: Therapeutically active organic compound exhibiting at least one group comprising a structure --S'--S"--R, wherein the group --S"--R is defined by R being an organic group comprised in a physiologically acceptable compound H--S"--R obtainable by the splitting of the disulfide bridge --S'--S"-- in said structure, in which compound H--S"--R the sulfur atom S" is bound to a carbon atom in a heterocyclic aromatic ring in R having a configuration being such that the compound H--S"--R, while maintaining physiological acceptability, is stabilized, by tautomerism or resonance involving the sulfur atom S" bound to R, so as to be mainly excluded from reaction involving thiol disulfide exchange; S' being bound to an aliphatic carbon atom; and said compound, in addition to the group or groups comprising the structure --S'--S"--R, consisting of a residue of a therapeutically active organic base compound of non-polypeptide structure bound to S'.Type: GrantFiled: April 29, 1985Date of Patent: June 23, 1992Assignee: Pharmacia AktiebolagInventors: Jan P. E. Carlsson, Rolf E. A. V. Axen
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Patent number: 4711951Abstract: Therapeutically active organic compound exhibiting at least one radical comprising a structure --S'--S"--R, where S"--R is defined by R being an organic group comprised in a physiologically acceptable compound H--S"--R obtainable by the splitting of the disulfide bridge --S'--S"-- in said structure, in which compound H--S"--R the sulfur atom S" is bound to a carbon atom in a heterocyclic aromatic ring in R having a configuration being such that the compound H--S"--R, while maintaining physiological acceptability, is stabilized, by tautomerism or resonance involving the sulfur atom S" bound to R, so as to be mainly excluded from further reaction involving thiol disulfide exchange; S' being bound to an aliphatic carbon atom; and said compound, in addition to the group or groups comprising the structure --S'--S"--R, also consisting of a residue of a therapeutically active organic base compound of polypeptide structure bound to S', for therapeutical use in mammals, including humans.Type: GrantFiled: March 29, 1984Date of Patent: December 8, 1987Assignee: Pharmacia AktiebolagInventors: Rolf E. A. V. Axen, Jan P. E. Carlsson
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Patent number: 4563304Abstract: Novel pyridine compounds having the formula R.sup.1 -S-S-A-Z are disclosed, in which formula R.sup.1 is 2-pyridyl, 5-nitro-2-pyridyl or 4-pyridyl, A is a hydrocarbon residue having 1-10 carbon atoms and Z is a group ##STR1## or acid addition salts of the last mentioned group, where n is 2 or 3, R.sup.1 has the same significance as R.sup.1 above and is equal thereto and R.sup.2 is methyl or ethyl. These compounds are particularly useful as bifunctional coupling agents and as thiolating agents.Type: GrantFiled: February 23, 1984Date of Patent: January 7, 1986Assignee: Pharmacia Fine Chemicals ABInventors: Jan P. E. Carlsson, Rolf E. A. V. Axen, Hakan N. Y. Drevin, Goran E. S. Lindgren
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Patent number: 4469796Abstract: An improvement in assaying methods involving biospecific affinity reactions, in which there are used from 2 to 4 reactants, one of which, reactant (I), is labelled with at least one analytically indicatable atom or group and is soluble in the aqueous liquid in which the biospecific affinity reaction is carried out, the reactants forming, by means of biospecific reactions, a conjugate in which labelled reactant (I) is incorporated; and in which assaying methods the analytically indicatable atom or group is assayed in the conjugate and/or in labelled reactant (I), which is not bound to the conjugate. The conjugate that has been formed or labelled reactant (I) not bound to the conjugate is bound covalently to an insoluble carrier or to an insolubilizable carrier, which latter carrier is made insoluble after the covalent binding has been carried out, whereafter the assay of the analytically indicatable atom or group is carried out.Type: GrantFiled: May 5, 1981Date of Patent: September 4, 1984Assignee: Pharmacia Diagnostics ABInventors: Rolf E. A. V. Axen, Sven O. H. Oscarsson, Per H. G. Ponterius, Jan P. E. Carlsson
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Patent number: 4232119Abstract: A reagent for use in immunochemical assay methods carried out in the presence of an aqueous liquid, which reagent comprises a conjugate of one or more molecules of immunoglobulin and one or more units of an analytically indicatable group which molecules and units are bound together via bridges containing the group, --S--S--, said conjugate being soluble in said aqueous liquid.Type: GrantFiled: March 2, 1978Date of Patent: November 4, 1980Assignee: Pharmacia Diagnostics ABInventors: Jan P. E. Carlsson, Rolf E. A. V. Axen, Hakan N. Y. Drevin
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Patent number: 4231999Abstract: A method of carrying out assaying methods involving biospecific affinity reactions in which there is used a component (I), which is labelled with at least one analytically indicatable group and is soluble in the liquid in whose presence the biospecific affinity reaction is carried out, for reaction with a counterpart (II) which exhibits biospecific affinity to (I) and optionally also one or more additional counterparts exhibiting biospecific affinity to (I) and/or (II), and forming an insoluble conjugate in which the labelled component (I) is incorporated and which conjugate is separated from the liquid phase, whereafter the analytically indicatable group is assayed in the insoluble conjugate, said method being characterized in that the analytically indicatable group is bound to the component (I) with a splittable bond of covalent nature and/or one of said counterparts is bound to a carrier, which is insoluble in said liquid, with a splittable bond of covalent nature, said splittable bonds being splittable unType: GrantFiled: March 2, 1978Date of Patent: November 4, 1980Assignee: Pharmacia Diagnostics ABInventors: Jan P. E. Carisson, Rolf E. A. V. Axen, Hakan N. Y. Drevin
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Patent number: 4175073Abstract: A novel class of reactive derivatives of polymers containing HS-groups is disclosed in which derivatives a number of the HS-groups are converted to a disulphide group of the formula -S-S-A-Z, where A is a hydrocarbon residue having 1-10 carbon atoms and Z is a group ##STR1## or acid addition salts of the last mentioned group, where n is 2 or 3, R.sup.1 is 2-pyridyl, 5-nitro-2-pyridyl or 4-pyridyl and R.sup.2 is methyl or ethyl. The novel derivatives may be used, for example, as thiolating agents or as carriers for e.g. enzymes or other proteins etc.Type: GrantFiled: March 2, 1978Date of Patent: November 20, 1979Assignee: Pharmacia Fine Chemicals ABInventors: Jan P. E. Carlsson, Rolf E. A. V. Axen, Hakan N. Y. Drevin, Goran E. S. Lindgren
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Patent number: 4149003Abstract: Novel pyridine compounds having the formula R.sup.1 -S-S-A-Z are disclosed, in which formula R.sup.1 is 2-pyridyl, 5-nitro-2-pyridyl or 4-pyridyl, A is a hydrocarbon residue having 1-10 carbon atoms and Z is a group ##STR1## or acid addition salts of the last mentioned group, where n is 2 or 3, R.sup.1 has the same significance as R.sup.1 above and is equal thereto and R.sup.2 is methyl or ethyl. These compounds are particularly useful as bifunctional coupling agents and as thiolating agents.Type: GrantFiled: March 2, 1978Date of Patent: April 10, 1979Assignee: Pharmacia Fine Chemicals ABInventors: Jan P. E. Carlsson, Rolf E. A. V. Axen, Hakan N. Y. Drevin, Goran E. S. Lindgren
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Patent number: RE29474Abstract: A process comprising contacting particles of water insoluble polymers to which have been bound antibodies, by means of covalent bonds, against the protein or polypeptide to be determined, wherein a certain quantity of the protein or polypeptide is labeled with a radioactive isotope, whereupon the particles, subsequent to the reaction between the protein or the polypeptide and the antibodies attached to the particles are separated from the sample liquid and the radioactivity of the particle material and/or in the liquid is determined.Type: GrantFiled: July 23, 1975Date of Patent: November 15, 1977Assignee: Pharmacia ABInventors: Rolf E. A. V. Axen, Jerker O. Porath, Leif Edvin Wide
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Patent number: RE29480Abstract: Method for determining vitamin B.sub.12 in aqueous samples by contacting said sample with radioactivity labelled vitamin B.sub.12 and with particles of water insoluble polymers to which substances capable of binding vitamin B.sub.12 have been bound, thereafter separating said particles and determining the radioactivity.Type: GrantFiled: July 23, 1975Date of Patent: November 22, 1977Assignee: Pharmacia ABInventors: Rolf E. A. V. Axen, Jerker O. Porath, Leif Edvin Wide