Patents by Inventor Rolf E. Swenson

Rolf E. Swenson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250134897
    Abstract: Disclosed are compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods of preparation thereof, wherein R1, Xa, Xb, Xc, and Xd are as described in the specification. Further disclosed is an isotopic mixture of a compound of Formula (I), as well as a pharmaceutical composition containing a hyperpolarized compound of Formula (I). Also disclosed is a method of diagnosing or monitoring a patient suffering from cancer, the method including administering a pharmaceutical composition comprising an effective amount of a hyperpolarized ketoglutarate compound or a pharmaceutically acceptable salt thereof, and measuring the hyperpolarization of a compound of interest in the patient. Further disclosed is a method of preparing hyperpolarized ketoglutarate compounds for use in the above methods.
    Type: Application
    Filed: January 26, 2023
    Publication date: May 1, 2025
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Rolf E. SWENSON, Jessica H. ETTEDGUI-BENJAMINI, Venkatareddy SABBASANI, Deepak SAIL, Kazutoshi YAMAMOTO, Murali K. CHERUKURI
  • Publication number: 20250032489
    Abstract: Mixed lineage kinase (MLK) inhibitors are disclosed. The compounds inhibit kinase activity. The compounds may be used to treat diseases or conditions characterized at least in part by overexpression of one or more MLKs. The compounds have a structure according to formula I, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 30, 2022
    Publication date: January 30, 2025
    Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services
    Inventors: John F. Brognard, Rolf E. Swenson, Amy L. Funk, Carolyn W. Hitko, Katherine M. Nyswaner, Knickole L. Bergman, Venkatareddy Sabbasani, Eric Lindberg, Steven D. Cappell, Meghri Katerji
  • Publication number: 20240216900
    Abstract: Disclosed are perfluorinated SABRE catalysts comprising a d-block element and a perfluorinated ligand, wherein the perfluorinated ligand is of Formula (I): [Lm-(NHC)—(Y—Z)q] or a salt thereof. Also disclosed is a method of preparing a hyperpolarized substrate comprising a ½ spin nucleus or nuclei using the perfluorinated SABRE catalysts, and isolating the resulting hyperpolarized substrate for administration to an animal. Further disclosed is a method of imaging a tissue of an animal suspected of having a disease or condition.
    Type: Application
    Filed: January 11, 2024
    Publication date: July 4, 2024
    Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services
    Inventors: Rolf E. Swenson, Jessica H. Ettedgui-Benjamini, Carolyn Woodroofe Hitko, Murali K. Cherukuri, Natarajan Raju
  • Publication number: 20240190838
    Abstract: Leucine zipper-bearing kinase (LZK) targeted degraders are disclosed. The compounds have a general formula Q-L-Z where Q is an LZK binding moiety, L is a linker, and Z is an E3-ligase binding moiety. The compounds inhibit LZK activity and/or degrade LZK. The compounds may be used to treat diseases or conditions characterized at least in part by LZK overexpression.
    Type: Application
    Filed: March 1, 2023
    Publication date: June 13, 2024
    Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services
    Inventors: John F. Brognard, Rolf E. Swenson, Amy L. Funk, Carolyn W. Hitko, Katherine M. Nyswaner, Eric Lindberg, Venkatareddy Sabbasani, Knickole L. Bergman
  • Publication number: 20230019760
    Abstract: Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.
    Type: Application
    Filed: September 21, 2022
    Publication date: January 19, 2023
    Inventors: Stephen E. Hidem, Aaron M. Fontaine, Janet L. Gelbach, Patrick M. McDonald, Kathryn M. Hunter, Rolf E. Swenson, Julius P. Zodda
  • Patent number: 11464896
    Abstract: Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: October 11, 2022
    Assignee: Bracco Diagnostics Inc.
    Inventors: Stephen E. Hidem, Aaron M. Fontaine, Janet L. Gelbach, Patrick M. McDonald, Kathryn M. Hunter, Rolf E. Swenson, Julius P. Zodda, Kimberly J. McDaniel
  • Publication number: 20210299348
    Abstract: Infusion system configurations and assemblies facilitate routing of infusion circuit tubing lines. Tubing lines are routed into and out from compartments of a shielding assembly for the infusion system, at locations which prevent kinking and/or crushing of the lines, and/or provide for ease in assembling the circuit. A plurality of the lines may be held together by a support frame to form a disposable infusion circuit subassembly, that can further facilitate routing of the lines.
    Type: Application
    Filed: March 26, 2021
    Publication date: September 30, 2021
    Inventors: Charles R. Quirico, Ernest Balestracci, Rolf E. Swenson, Daniel Darst, Eric J. Krause, Vishal N. Lokhande, Jacob S. Childs
  • Patent number: 10994072
    Abstract: Infusion system configurations and assemblies facilitate routing of infusion circuit tubing lines. Tubing lines are routed into and out from compartments of a shielding assembly for the infusion system, at locations which prevent kinking and/or crushing of the lines, and/or provide for ease in assembling the circuit. A plurality of the lines may be held together by a support frame to form a disposable infusion circuit subassembly, that can further facilitate routing of the lines.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: May 4, 2021
    Assignee: Bracco Diagnostics Inc.
    Inventors: Charles R. Quirico, Ernest Balestracci, Rolf E. Swenson, Daniel D. Darst, Eric J. Krause, Vishal N. Lokhande, Jacob S. Childs
  • Patent number: 10995004
    Abstract: A method of increasing a density of carboxylic acids on a surface of a carbon nanoparticle is disclosed. The method includes contacting an oxygen-containing functional group on a surface of a carbon nanoparticle with a reducing agent to provide a hydroxyl group; reacting the hydroxyl group with a diazoacetate ester in the presence of a transition metal catalyst to provide an ester, the diazoacetate ester having the structure wherein R is a C1-8 hydrocarbyl, preferably tert-butyl, methyl, ethyl, isopropyl, allyl, benzyl, pentafluorophenyl, or N-succinimidyl; and cleaving the ester to provide a carboxylic acid group. Surface-functionalized carbon nanoparticles made by the method are also disclosed.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: May 4, 2021
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Keir Cajal Neuman, Ganesh Shenoy, Chandrasekhar Mushti, Rolf E. Swenson
  • Publication number: 20200207627
    Abstract: A method of increasing a density of carboxylic acids on a surface of a carbon nanoparticle is disclosed. The method includes contacting an oxygen-containing functional group on a surface of a carbon nanoparticle with a reducing agent to provide a hydroxyl group; reacting the hydroxyl group with a diazoacetate ester in the presence of a transition metal catalyst to provide an ester, the diazoacetate ester having the structure wherein R is a C1-8 hydrocarbyl, preferably tert-butyl, methyl, ethyl, isopropyl, allyl, benzyl, pentafluorophenyl, or N-succinimidyl; and cleaving the ester to provide a carboxylic acid group. Surface-functionalized carbon nanoparticles made by the method are also disclosed.
    Type: Application
    Filed: September 29, 2017
    Publication date: July 2, 2020
    Inventors: Keir Cajal Neuman, Ganesh Shenoy, Chandrasekhar Mushti, Rolf E. Swenson
  • Publication number: 20190307949
    Abstract: Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.
    Type: Application
    Filed: May 24, 2019
    Publication date: October 10, 2019
    Inventors: Stephen E. Hidem, Aaron M. Fontaine, Janet L. Gelbach, Patrick M. McDonald, Kathryn M. Hunter, Rolf E. Swenson, Julius P. Zodda
  • Patent number: 10376630
    Abstract: Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: August 13, 2019
    Assignee: Bracco Diagnostics Inc.
    Inventors: Stephen E. Hidem, Aaron M. Fontaine, Janet L. Gelbach, Patrick M. McDonald, Kathryn M. Hunter, Rolf E. Swenson, Julius P. Zodda
  • Patent number: 10335537
    Abstract: Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: July 2, 2019
    Assignee: Bracco Diagnostics Inc.
    Inventors: Stephen E. Hidem, Aaron M. Fontaine, Janet L. Gelbach, Patrick M. McDonald, Kathryn M. Hunter, Rolf E. Swenson, Julius P. Zodda
  • Publication number: 20190060558
    Abstract: Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.
    Type: Application
    Filed: October 3, 2018
    Publication date: February 28, 2019
    Inventors: Stephen E. Hidem, Aaron M. Fontaine, Janet L. Gelbach, Patrick M. McDonald, Kathryn M. Hunter, Rolf E. Swenson, Julius P. Zodda
  • Publication number: 20180361057
    Abstract: Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.
    Type: Application
    Filed: August 27, 2018
    Publication date: December 20, 2018
    Inventors: Stephen E. Hidem, Aaron M. Fontaine, Janet L. Gelbach, Patrick M. McDonald, Kathryn M. Hunter, Rolf E. Swenson, Julius P. Zodda
  • Publication number: 20180093035
    Abstract: Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.
    Type: Application
    Filed: November 10, 2017
    Publication date: April 5, 2018
    Inventors: Stephen E. Hidem, Aaron M. Fontaine, Janet L. Gelbach, Patrick M. McDonald, Kathryn M. Hunter, Rolf E. Swenson, Julius P. Zodda
  • Patent number: 9814826
    Abstract: Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: November 14, 2017
    Assignee: Bracco Diagnostics Inc.
    Inventors: Stephen E. Hidem, Aaron M. Fontaine, Janet L. Gelbach, Patrick M. McDonald, Kathryn M. Hunter, Rolf E. Swenson, Julius P. Zodda
  • Publication number: 20170274138
    Abstract: Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.
    Type: Application
    Filed: June 12, 2017
    Publication date: September 28, 2017
    Inventors: Stephen E. Hidem, Aaron M. Fontaine, Janet L. Gelbach, Patrick M. McDonald, Kathryn M. Hunter, Rolf E. Swenson, Julius P. Zodda
  • Patent number: 9750869
    Abstract: Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: September 5, 2017
    Assignee: Bracco Diagnostics, Inc.
    Inventors: Stephen E. Hidem, Aaron M. Fontaine, Janet L. Gelbach, Patrick M. McDonald, Kathryn M. Hunter, Rolf E. Swenson, Julius P. Zodda
  • Patent number: 9750870
    Abstract: Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: September 5, 2017
    Assignee: Bracco Diagnostics, Inc.
    Inventors: Stephen E. Hidem, Aaron M. Fontaine, Janet L. Gelbach, Patrick M. McDonald, Kathryn M. Hunter, Rolf E. Swenson, Julius P. Zodda