Patents by Inventor Rolf F. Barth

Rolf F. Barth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carboranyl uridines and their use in boron neutron capture therapy
    Patent number: 5466679
    Abstract: The invention relates to novel boron-containing nucleosides and amino acids which can utilize the enzymatic systems in tumor cells for incorporating such boron-containing structures into nucleic acids and proteins. Subsequent use of boron neutron capture therapy provides a method for treating tumor cells.
    Type: Grant
    Filed: March 7, 1994
    Date of Patent: November 14, 1995
    Assignee: The Ohio State University Research Foundation
    Inventors: Albert H. Soloway, Rolf F. Barth, Abul K. Anisuzzaman, Werner Tjarks, Feng-Guang Rong, Iwona M. Wyzlic
  • 2' and 3' Carboranyl uridines and their diethyl ether adducts
    Patent number: 5171849
    Abstract: There is disclosed a process for preparing carboranyl uridine nucleoside compounds and their diethyl ether adducts, which exhibit a tenfold increase in boron content over prior art boron containing nucleoside compounds. Said carboranyl uridine nucleoside compounds exhibit enhanced lipophilicity and hydrophilic properties adequate to enable solvation in aqueous media for subsequent incorporation of said compounds in methods for boron neutron capture therapy in mammalian tumor cells.
    Type: Grant
    Filed: April 19, 1991
    Date of Patent: December 15, 1992
    Assignee: The Ohio State University Research Foundation
    Inventors: Albert H. Soloway, Rolf F. Barth, Abul K. Anisuzzaman, Fazlul Alam, Werner Tjarks