Patents by Inventor Rolf F. Kletzien

Rolf F. Kletzien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND OTHER METABOLIC DISEASES
    Publication number: 20160051529
    Abstract: The present invention relates to PPARy-sparing compounds and pharmaceutical compositions formulated with such compounds that are useful for treating, delaying the onset of, or reducing the symptoms of a neurodegenerative disorder including Huntington's disease, epilepsy, AMS, and MS.
    Type: Application
    Filed: December 5, 2013
    Publication date: February 25, 2016
    Inventors: Gerard R. Colca, Rolf F. Kletzien
  • Thiazolidinedione analogues
    Patent number: 9155729
    Abstract: The present invention relates to thiazolidinedione analogs that are useful for treating metabolic inflammation mediated diseases such as diabetes.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: October 13, 2015
    Assignee: Metabolic Solutions Development Company, LLC
    Inventors: Gerard R. Colca, Rolf F. Kletzien
  • Thiazolidinedione Analogues
    Publication number: 20150190385
    Abstract: The present invention relates to thiazolidinedione analogues that are useful for treating metabolic inflammation mediated diseases such as diabetes.
    Type: Application
    Filed: December 30, 2014
    Publication date: July 9, 2015
    Inventors: Gerard R. Colca, Rolf F. Kletzien
  • Thiazolidinedione analogues
    Patent number: 8629159
    Abstract: The present invention relates to thiazolidinedione analogues that are useful for treating hypertension.
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: January 14, 2014
    Assignee: Metabolic Solutions Development Company, LLC
    Inventors: Gerard R. Colca, Rolf F. Kletzien
  • Thiazolidinedione analogues
    Patent number: 8389556
    Abstract: The present invention relates to methods of using thiazolidinedione analogues of formula I: for treating Alzheimer's disease The terms R1, R2 and R3 are herein defined.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: March 5, 2013
    Assignee: Metabolic Soultions Development Company, LLC
    Inventors: Gerard R. Colca, Rolf F. Kletzien
  • PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20130053350
    Abstract: The present invention relates to thiazolidinedione analogues and pharmaceutical compositions that are useful for treating and/or preventing neurodegenerative disorders.
    Type: Application
    Filed: December 15, 2010
    Publication date: February 28, 2013
    Applicant: Metabolic Solutions Development Company, LLC
    Inventors: Gerard R. Colca, Rolf F. Kletzien, Steve P. Tanis, Scott D. Larsen
  • PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF DIABETES MELLITUS AND OTHER METABOLIC DISEASES
    Publication number: 20120322728
    Abstract: The present invention relates to thiazolidinedione analogues and pharmaceutical compositions that are useful for treating and/or preventing diabetes mellitis, optionally in combination with a second treatment. Furthermore, the present invention also provides methods of inducing remission of the symptoms of diabetes mellitis in a patient comprising administering a thiazolidinedione analogue and a GLP-1 agonist.
    Type: Application
    Filed: December 15, 2010
    Publication date: December 20, 2012
    Applicant: Metabolic Solutions Development Company, LLC
    Inventors: Gerard R. Colca, Rolf F. Kletzien, Steven P. Tanis, Scott D. Larsen
  • PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF OBESITY AND OTHER METABOLIC DISEASES
    Publication number: 20120316138
    Abstract: The present invention relates to thiazolidinedione analogues and pharmaceutical compositions that are useful for treating and/or preventing obesity or diabetes, optionally in combination with a second treatment therapy such a diet restriction or an increase in duration or exertion in physical activity.
    Type: Application
    Filed: December 15, 2010
    Publication date: December 13, 2012
    Applicant: METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC
    Inventors: Gerard R. Colca, Rolf F. Kletzien, Steven P. Tanis, Scott D. Larsen
  • Thiazolidinedione analogues
    Publication number: 20120015982
    Abstract: The present invention relates to thiazolidinedione analogues that are useful for treating metabolic inflammation mediated diseases such as diabetes.
    Type: Application
    Filed: May 18, 2011
    Publication date: January 19, 2012
    Applicant: Metabolic Solutions Development Company
    Inventors: Gerard R. Colca, Rolf F. Kletzien
  • Thiazolidinedione analogues
    Publication number: 20090143442
    Abstract: The present invention relates to thiazolidinedione analogues that are useful for treating metabolic inflammation mediated diseases such as diabetes.
    Type: Application
    Filed: September 16, 2008
    Publication date: June 4, 2009
    Inventors: Gerard R. Colca, Rolf F. Kletzien
  • Thiazolidinedione analogues
    Publication number: 20090137638
    Abstract: The present invention relates to thiazolidinedione analogues that are useful for treating hypertension.
    Type: Application
    Filed: September 16, 2008
    Publication date: May 28, 2009
    Inventors: Gerard R. Colca, Rolf F. Kletzien
  • Human caspase-12 materials and methods
    Patent number: 6833248
    Abstract: The present invention provides novel human caspase-12 polynucleotides and polypeptides; constructs and recombinant host cells incorporating the polynucleotides; the human caspase-12 polypeptides encoded by the polynucleotides; antibodies to the polypeptides; and methods of making and using all of the foregoing.
    Type: Grant
    Filed: May 8, 2001
    Date of Patent: December 21, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Rolf F. Kletzien, Ilene M. Reardon, Katherine L. Weiland
  • Human caspase-12 materials and methods
    Publication number: 20030165488
    Abstract: The present invention provides novel human caspase-12 polynucleotides and polypeptides; constructs and recombinant host cells incorporating the polynucleotides; the human caspase-12 polypeptides encoded by the polynucleotides; antibodies to the polypeptides; and methods of making and using all of the foregoing.
    Type: Application
    Filed: May 8, 2001
    Publication date: September 4, 2003
    Inventors: Rolf F. Kletzien, llene M. Reardon, Katherine L. Weiland
  • 4-hydroxycoumarin-3-carboxamides for the treatment of diabetes mellitus
    Patent number: 5723476
    Abstract: The present invention provides some novel 4-hydroxycoumarin-3-carboxamide derivatives and the use of a broad class of 4-hydroxycoumarin-3-carboxamide derivatives for the treatment of a patient suffering from or susceptible to diabetes mellitus.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: March 3, 1998
    Assignee: Pharmacia & Upjohn Company
    Inventors: Scott D. Larsen, Jerry R. Colca, Peter K. W. Harris, Howard R. Miller, Alice L. Laborde, Rolf F. Kletzien, Heinrich Josef Schostarez