Abstract: A chromatographic interface for sample handling and manipulation between separations or analyses is provided. The interface has an interfacing unit, a sample acquisition unit, and a sample trapping unit. The sample acquisition unit includes an inflow selector valve, an outflow selector valve, and one or more collection loops. The sample trapping unit includes a trap in fluid communication with the loop and having a stationary phase. The stationary phase can trap an analyte of interest from a fraction of the chromatographic sample separation flow. The tapping unit also has a scavenging gas source and a vacuum source; both can be used to substantially dry the stationary phase.

Abstract: An apparatus for chromatographic interfacing includes an interfacing unit, a sample acquisition unit, and a sample trapping unit. The interfacing unit includes (i) a chromatographic inflow valve adapted to receive a chromatographic sample separation flow, (ii) a chromatographic outflow valve adapted to allow discharge of the sample separation flow, (iii) a loop expulsion inflow valve adapted to receive an expulsion fluid flow, and (iv) a loop expulsion outflow valve in fluid communication with the loop expulsion inflow valve and adapted to allow discharge of a fluid. The sample acquisition unit includes (i) an inflow selector in selectable fluid communication with the chromatographic inflow valve or the loop expulsion inlet valve, (ii) an outflow selector in fluid communication with the loop expulsion outflow valve, and (iii) one or more collection loops, each loop being independently selectable to establish fluid communication between the inflow selector valve and the outflow selector valve.