Patents by Inventor Rolf Grosser

Rolf Grosser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane
    Patent number: 7709644
    Abstract: The present invention relates to a process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane with the aid of continuous countercurrent chromatography, which is also described as SMB chromatography (SMB=simulated moving bed). In a further aspect, the invention relates to a process for the preparation of (1S,6R)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane using the aforementioned process, which furthermore includes a racemization step.
    Type: Grant
    Filed: January 9, 2007
    Date of Patent: May 4, 2010
    Assignee: LANXESS Deutschland GmbH
    Inventors: Herbert Diehl, Andreas Krebs, Elvira Krebs, legal representative, Walter Lange, Hanns-Ingolf Paul, Dietrich Seidel, Rolf Grosser, Tobias Reichelt
  • Substituted quinazolines as antiviral agents, especially against cytomegaloviruses
    Patent number: 7709491
    Abstract: The invention relates to substituted quinazolines and to methods for the production thereof, in addition to the use thereof in the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.
    Type: Grant
    Filed: October 25, 2003
    Date of Patent: May 4, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Tobias Wunberg, Judith Baumeister, Mario Jeske, Susanne Nikolic, Frank Süβmeier, Holger Zimmermann, Rolf Grosser, Kerstin Henninger, Guy Hewlett, Jörg Keldenich, Dieter Lang, Tse-I Lin
  • SUBSTITUTED 7-SULFANYLMETHYL-, 7-SULFINYLMETHYL- AND 7-SULFONYLMETHYLINDOLES AND THE USE THEREOF
    Publication number: 20100105744
    Abstract: The present application relates to novel 7-sulfanylmethyl-, 7-sulfinylmethyl- and 7-sulfonylmethylindole derivatives, processes for the preparation thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases, and the use thereof for the manufacture of medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
    Type: Application
    Filed: June 24, 2009
    Publication date: April 29, 2010
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Peter Kolkhof, Astrid Brüns, Kai Thede, Karl-Heinz Schlemmer, Alexander Hillisch, Dieter Lang, Michael Gerisch, Andreas Göller, Rolf Grosser, Carsten Schmeck, Elisabeth Woltering, Olaf Prien, Holger Paulsen, Armin Kern
  • 5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS
    Publication number: 20100035902
    Abstract: The present application relates to novel aryl-substituted heterobicyclic compounds, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
    Type: Application
    Filed: May 25, 2007
    Publication date: February 11, 2010
    Applicant: BAYER HEALTHCARE AG
    Inventors: Santiago Figueroa Perez, Peter Kolkhof, Lars Bärfacker, Ingo Flamme, Karl-Heinz Schlemmer, Alexander Kuhl, Rolf Grosser, Klaus Münter, Andreas Knorr
  • 4-Chromenonyl-1,4-dihydropyridines and their use
    Publication number: 20100022484
    Abstract: The present application relates to novel 4-chromenonyl-1,4-dihydropyridines, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
    Type: Application
    Filed: July 12, 2006
    Publication date: January 28, 2010
    Inventors: Alexander Kuhl, Peter Kolkhof, Heike Heckroth, Karl-Heinz Schlemmer, Ingo Flamme, Santiago Gigueroa Perez, Heike Gielen-Haertwig, Rolf Grosser, Jens-Kerim Ergüden, Dieter Lang
  • 4-Chromenonyl-1,4-dihydropyridinecarbonitriles and the use thereof
    Publication number: 20090214675
    Abstract: The present application relates to novel 4-chromenonyl-1,4-dihydropyridinecarbonitriles, processes for their preparation, pharmaceutical compositions containing them, and their use for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
    Type: Application
    Filed: July 14, 2006
    Publication date: August 27, 2009
    Applicant: Bayer HealthCare AG
    Inventors: Alexander Kuhl, Peter Kolkhof, Heike Heckroth, Karl-Heinz Schlemmer, Ingo Flamme, Santiago Figueroa Perez, Heike Gielen-Haertwig, Rolf Grosser, Jens-Kerim Ergüden, Dieter Lang
  • Optically active pyridine derivative and a medicament containing the same
    Publication number: 20090054424
    Abstract: An optically active (?)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one of the formula: or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.
    Type: Application
    Filed: May 19, 2008
    Publication date: February 26, 2009
    Inventors: Toshiki Murata, Sachiko Sakakibara, Takashi Yoshino, Hiroki Sato, Yuji Koriyama, Noriko Nunami, Megumi Yamauchi, Keiko Fukushima, Rolf Grosser, Kinji Fuchikami, Kevin Bacon, Timothy Lowinger
  • Optically active 2,5-bisaryl-delta¹ -pyrrolines and their use as pest control agents
    Publication number: 20090012144
    Abstract: Novel optically active ?1-pyrrolines of the formula (I) in which R1, R2, R3, R4, and m are each as defined in the description, a plurality of the processes for preparing these substances and their use for controlling pests.
    Type: Application
    Filed: July 28, 2008
    Publication date: January 8, 2009
    Inventors: Andrew Plant, Thomas Geller, Bernd Gallenkamp, Rolf Grosser, Albrecht Marhold, Christoph Erdelen, Andreas Turberg, Olaf Hansen
  • Optically active 2,5-bisaryl-?-pyrrolines and their use as pest control agents
    Patent number: 7419936
    Abstract: Novel optically active ?1-pyrrolines of the formula (I) in which R1, R2, R3, R4, and m are each as defined in the description, a plurality of the processes for preparing these substances and their use for controlling pests.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: September 2, 2008
    Assignee: Bayer CropScience AG
    Inventors: Andrew Plant, Thomas Geller, Bernd Gallenkamp, Rolf Grosser, Albrecht Marhold, Christoph Erdelen, Andreas Turberg, Olaf Hansen
  • Optically active pyridine derivative and a medicament containing the same
    Patent number: 7375103
    Abstract: An optically active (?)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one of the formula (I) or salt thereof.
    Type: Grant
    Filed: March 3, 2003
    Date of Patent: May 20, 2008
    Assignee: Bayer HealthCare AG
    Inventors: Toshiki Murata, Sachiko Sakakibara, Takashi Yoshino, Hiroki Sato, Yuji Koriyama, Noriko Nunami, Megumi Yamauchi, Keiko Fukushima, Rolf Grosser, Kinji Fuchikami, Kevin Bacon, Timothy Lowinger
  • (-)-Enantiomer of the 2-[2-(1-chloro-cyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-[1,2,4]-triazole-3-thione
    Publication number: 20080113864
    Abstract: A novel (?)-enantiomer of 2-[2-(1-chloro-cyclopropyl)-3-(2-chloro-phenyl)-2-hydroxypropyl]-2,4-dihydro-[1,2,4]-triazole-3-thione of the formula a process for preparing this novel active compound and its use as microbicide in crop protection and in the protection of materials.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 15, 2008
    Inventors: Rolf Grosser, Manfred Jautelat, Astrid Mauler-Machnik, Stefan Dutzmann, Gerd Hanssler, Klaus Stenzel
  • Substituted Dihydroquinazolines II
    Publication number: 20070281953
    Abstract: The invention relates to substituted dihydroquinazolines and to a method for the production thereof, the use thereof for treating and/or preventing diseases and for producing drugs for treating and/or preventing diseases, in particular for the use of the inventive dihydroquinazolines in the form of antiviral agents, in particular against cytomegaloviruses.
    Type: Application
    Filed: October 28, 2004
    Publication date: December 6, 2007
    Applicant: Bayer HealthCare AG
    Inventors: Tobias Wunberg, Judith Baumeister, Mario Jeske, Peter Nell, Susanne Nikolic, Frank Sussmeier, Holger Zimmermann, Rolf Grosser, Guy Hewlett, Jorg Keldenich, Dieter Lang, Kerstin Henninger
  • Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane
    Publication number: 20070213536
    Abstract: The present invention relates to a process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane with the aid of continuous countercurrent chromatography, which is also described as SMB chromatography (SMB=simulated moving bed). In a further aspect, the invention relates to a process for the preparation of (1S,6R)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane using the aforementioned process, which furthermore includes a racemization step.
    Type: Application
    Filed: January 9, 2007
    Publication date: September 13, 2007
    Inventors: Herbert Diehl, Andreas Krebs, Elvira Krebs, Walter Lange, Hanns-Ingolf Paul, Dietrich Seidel, Rolf Grosser, Tobias Reichelt
  • Substituted dihydroquinazolines
    Publication number: 20070191387
    Abstract: The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.
    Type: Application
    Filed: March 26, 2007
    Publication date: August 16, 2007
    Applicant: Bayer HealthCare AG
    Inventors: Tobias Wunberg, Judith Baumeister, Ulrich Betz, Mario Jeske, Thomas Lampe, Susanne Nikolic, Jurgen Reefschlager, Rudolf Schohe-Loop, Frank Sussmeier, Holger Zimmermann, Rolf Grosser, Kerstin Henninger, Guy Hewlett, Jorg Keldenich, Dieter Lang, Peter Nell
  • Heterocyclyl-substituted dihydroquinazolines and their use as antiviral agents
    Publication number: 20070185121
    Abstract: The invention relates to heterocyclyl-substituted dihydroquinazolines of formula (I), to processes for their preparation, to medicaments containing them, and to methods for the treatment and/or prophylaxis of diseases, in particular, for use as anti-viral agents, in particular, against cytomegaloviruses.
    Type: Application
    Filed: April 28, 2004
    Publication date: August 9, 2007
    Applicant: Bayer HealthCare AG
    Inventors: Tobias Wunberg, Judith Baumeister, Mario Jeske, Peter Nell, Susanne Nikolic, Frank Sussmeier, Holger Zimmermann, Rolf Grosser, Kerstin Henninger, Guy Hewlett, Jorg Keldenich, Dieter Lang
  • Substituted dihydroquinazolines
    Patent number: 7196086
    Abstract: The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: March 27, 2007
    Assignee: Bayer HealthCare AG
    Inventors: Tobias Wunberg, Judith Baumeister, Ulrich Betz, Mario Jeske, Thomas Lampe, Susanne Nikolic, Jürgen Reefschläger, Rudolf Schohe-Loop, Frank Süssmeier, Holger Zimmermann, Rolf Grosser, Kerstin Henninger, Guy Hewlett, Jörg Keldenich, Dieter Lang, Peter Nell
  • 2-(3-Phenyl-2-piperazinyl-3,4-dihydroquinazolin-4-yl)acetic acids as antiviral agents, especially against cytomegaloviruses
    Publication number: 20070066622
    Abstract: The invention relates to dihydroquinazolines and methods for the production thereof, the use thereof in the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments in the treatment and/or prophylaxis of diseases, especially for use as anti-viral agents, especially against cytomegalo viruses.
    Type: Application
    Filed: January 29, 2004
    Publication date: March 22, 2007
    Inventors: Tobias Wunberg, Judith Baumeister, Ulrich Betz, Mario Jeske, Gerald Kleymann, Thomas Lampe, Susanne Nikolic, Jurgen Reefshlager, Rudolf Schohe-Loop, Frank Submeier, Holger Zimmermann, Rolf Grosser, Kerstin Henninger, Guy Hewlett, Jorg Keldenich, Thomas Kramer, Peter Nell, Tse-I Lin
  • Substituted quinazolines as antiviral agents, especially against cytomegaloviruses
    Publication number: 20060235032
    Abstract: The invention relates to substituted quinazolines and to methods for the production thereof, in addition to the use thereof in the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.
    Type: Application
    Filed: October 25, 2003
    Publication date: October 19, 2006
    Inventors: Tobias Wunberg, Judith Baumeister, Mario Jeske, Susanne Nikolic, Frank Submeier, Holger Zimmermann, Rolf Grosser, Kerstin Henninger, Guy Hewlett, Jorg Keldenich, Dieter Lang, Tse-I Lin
  • Phenyl sulfoxides and phenyl sulfones
    Publication number: 20050227995
    Abstract: The invention relates to phenyl sulfoxides and sulfones and processes for their preparation, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially Alzheimer's disease.
    Type: Application
    Filed: January 7, 2003
    Publication date: October 13, 2005
    Inventors: Martin Hendrix, Karlheinz Baumann, Rolf Grosser, Gerhard Konig, Vera Dusterhus, Joachim Kruger
  • Optically active pyridine derivative and a medicament containing the same
    Publication number: 20050215547
    Abstract: An optically active (?)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]?-azin-2-one of the formula (I) or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.
    Type: Application
    Filed: March 3, 2003
    Publication date: September 29, 2005
    Applicant: Bayer HealthCare AG
    Inventors: Toshiki Murata, Sachiko Sakakibara, Takashi Yoshino, Hiroki Sato, Yuji Koriyama, Noriko Nunami, Megumi Yamauchi, Keiko Fukushima, Rolf Grosser, Kinji Fuchikami, Kevin Bacon, Timothy Lowinger