Patents by Inventor Rolf Hilgenfeld

Rolf Hilgenfeld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230099089
    Abstract: A substance of the formula (1) and its use as an antiviral active substance.
    Type: Application
    Filed: February 9, 2021
    Publication date: March 30, 2023
    Inventors: Rolf Hilgenfeld, Daizong Lin, Linlin Zhang
  • Patent number: 9284659
    Abstract: A method for crystallizing a substance dissolved in a solvent, including the following steps: introducing a solvent volume containing the substance into a chamber having a preset temperature, humidity, and gas composition, adding a predetermined volume of a precipitant to the solvent volume containing the substance, allowing the solvent to evaporate while simultaneously observing structural changes in the solvent volume containing the substance and the precipitant by means of dynamic light scattering, detecting weight changes and determining the molarities, making an association with the location in the phase diagram on the basis of the DLS measurement and the results of the molarity determination, allowing a predetermined number of crystal nuclei to form by adding solvent or adding precipitant, putting the solvent volume containing the substance and the precipitant into a metastable state by adding solvent and/or protein solution or by allowing the concentration of the dissolved substance to decrease by allo
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: March 15, 2016
    Assignee: Xtal Concepts GmbH
    Inventors: Christian Betzel, Rolf Hilgenfeld, Dierk Hilterhaus, Thomas Klupsch, Peter Muehlig, Karsten Dierks, Arne Meyer
  • Publication number: 20130139749
    Abstract: A method for crystallizing a substance dissolved in a solvent, including the following steps: introducing a solvent volume containing the substance into a chamber having a preset temperature, humidity, and gas composition, adding a predetermined volume of a precipitant to the solvent volume containing the substance, allowing the solvent to evaporate while simultaneously observing structural changes in the solvent volume containing the substance and the precipitant by means of dynamic light scattering, detecting weight changes and determining the molarities, making an association with the location in the phase diagram on the basis of the DLS measurement and the results of the molarity determination, allowing a predetermined number of crystal nuclei to form by adding solvent or adding precipitant, putting the solvent volume containing the substance and the precipitant into a metastable state by adding solvent and/or protein solution or by allowing the concentration of the dissolved substance to decrease by allo
    Type: Application
    Filed: June 30, 2011
    Publication date: June 6, 2013
    Applicants: UNIVERSITAET HAMBURG, UNIVERSITAET ZU LUEBECK
    Inventors: Christian Betzel, Rolf Hilgenfeld, Dierk Hilterhaus, Thomas Klupsch, Peter Muehlig, Karsten Dierks, Arne Meyer
  • Patent number: 7956078
    Abstract: The invention relates to a method of developing a main proteinase SARS inhibitor. Human coronaviruses are major causes of upper respiratory tract illnesses in humans, in particular, the common cold. Recent investigations have shown that a novel coronavirus causes the Severe Acute Respiratory Syndrome (SARS), a disease that is characterized by high fever, malaise, rigor, headache, non-productive cough or dyspnea, which is rapidly spreading. Within the scope of the invention, based on the structural analysis of the binding mode of the SARS Mpro enzyme, a group of prototype inhibitors is provided that acts as suitable drugs targeting a majority of viral infections of the respiratory tract, including SARS.
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: June 7, 2011
    Assignee: Universitat zu Luebeck
    Inventors: Rolf Hilgenfeld, Kanchan Anand, John Ziebuhr, Jeroen R. Mesters, Parvesh Wadhwani
  • Publication number: 20110086813
    Abstract: The present invention relates to a novel class of guanine nucleotide analogs which inhibit RelA and Relseq synthetic activity and which possess anti-bacterial activity. The present invention also relates to pharmaceutical compositions that include such compounds, and to methods of use of such compounds or compositions for combating bacteria and treating bacterial infections.
    Type: Application
    Filed: March 18, 2009
    Publication date: April 14, 2011
    Inventors: Gad Glaser, Jehoshua Katzhendler, Rolf Hilgenfeld, Roee Vidavski, Ezequiel Wexselblatt, Tamar Prez-Menahemov, Ilana Kaspy
  • Publication number: 20090137818
    Abstract: The invention relates to a method of developing a main proteinase SARS inhibitor. Human coronaviruses are major causes of upper respiratory tract illnesses in humans, in particular, the common cold. Recent investigations have shown that a novel coronavirus causes the Severe Acute Respiratory Syndrome (SARS), a disease that is characterized by high fever, malaise, rigor, headache, non-productive cough or dyspnea, which is rapidly spreading. Within the scope of the invention, based on the structural analysis of the binding mode of the SARS Mpro enzyme, a group of prototype inhibitors is provided that acts as suitable drugs targeting a majority of viral infections of the respiratory tract, including SARS.
    Type: Application
    Filed: November 10, 2005
    Publication date: May 28, 2009
    Inventors: Rolf Hilgenfeld, Kanchan Anand, John Ziebuhr, Jeroen R. Mesters, Parvesh Wadhwani
  • Patent number: 7137734
    Abstract: The invention relates to a device for measuring quantities of heat while simultaneously measuring the evaporation kinetics and/or condensation kinetics of the most minute amounts of liquid in order to determine thermodynamic parameters. The aim of the invention is to determine low thermal outputs, which are absorbed or released by the sample, as well as small differences between thermal outputs with regard to a reference measurement of the same magnitude. To this end, a most minute amount of liquid is located inside a measuring chamber having a constant temperature and air humidity. At least one thermal sensor is provided for repeatedly measuring the thermal radiation emitted from the most minute amount of liquid. A measuring means serves to determine the time-dependent change in the most minute amount of liquid. A computer is assigned to the measuring chamber in order to register, display, evaluate and/or subsequently process the measured values.
    Type: Grant
    Filed: February 11, 2003
    Date of Patent: November 21, 2006
    Assignee: IMB Institut Fuer Molekulare Biotechnologie E.V.
    Inventors: Peter Muehlig, Thomas Klupsch, Rolf Hilgenfeld, Hans-Juergen Kiel, Axel Walter
  • Publication number: 20050141587
    Abstract: The invention relates to a device for measuring quantities of heat while simultaneously measuring the evaporation kinetics and/or condensation kinetics of the most minute amounts of liquid in order to determine thermodynamic parameters. The aim of the invention is to determine low thermal outputs, which are absorbed or released by the sample, as well as small differences between thermal outputs with regard to a reference measurement of the same magnitude. To this end, a most minute amount of liquid is located inside a measuring chamber having a constant temperature and air humidity. At least one thermal sensor is provided for repeatedly measuring the thermal radiation emitted from the most minute amount of liquid. A measuring means serves to determine the time-dependent change in the most minute amount of liquid. A computer is assigned to the measuring chamber in order to register, display, evaluate and/or subsequently process the measured values.
    Type: Application
    Filed: February 11, 2003
    Publication date: June 30, 2005
    Inventors: Peter Muhlig, Thomas Klupsch, Rolf Hilgenfeld, Hans-Jurgen Kiel, Axel Walter
  • Patent number: 5824874
    Abstract: The polypeptide with the sequence (SEQ ID NO:1)Ala-Thr-Tyr-Asn-Gly-Lys-Cys-Tyr-Lys-Lys-Asp-Asn-Ile-Cys-Lys-Tyr-Lys-Ala-Gln -Ser-Gly-Lys-Thr-Ala-Ile-Cys-Lys-Cys-Tyr-Val-Lys-Lys-Cys-Pro-Arg-Asp-Gly-Al a-Lys-Cys-Glu-Phe-Asp-Ser-Tyr-Lys-Gly-Lys-Cys-Tyr-Cyscan be produced by the fermentation of Aspergillus giganteus and used as an antifungal agent.Expression of this polypeptide gene in plants strongly inhibits the growth of phytopathogenic fungi on the plant.
    Type: Grant
    Filed: July 29, 1996
    Date of Patent: October 20, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Norbert Ulbrich, Rolf Hilgenfeld, Heinz Hanel, Burkhard Sachse, Peter Braun, Joachim Wink, Peter Eckes, Jurgen Logemann, Jozef Schell
  • Patent number: 5589624
    Abstract: The polypeptide with the sequence (SEQ ID NO: 1)______________________________________ Ala--Thr--Tyr--Asn--Gly--Lys--Cys--Tyr--Lys--Lys--Asp-- Asn--Ile--Cys--Lys--Tyr--Lys--Ala--Gln--Ser--Gly--Lys-- Thr--Ala--Ile--Cys--Lys--Cys--Tyr--Val--Lys--Lys--Cys-- Pro--Arg--Asp--Gly--Ala--Lys--Cys--Glu--Phe--Asp--Ser-- Tyr--Lys--Gly--Lys--Cys--Tyr--Cys ______________________________________can be produced by the fermentation of Aspergillus giganteus and used as an antifungal agent.Expression of this polypeptide gene in plants strongly inhibits the growth of phytopathogenic fungi on the plant.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: December 31, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Norbert Ulbrich, Rolf Hilgenfeld, Heinz Hanel, Burkhard Sachse, Peter Braun, Joachim Wink, Peter Eckes, Jurgen Logemann, Jozef Schell
  • Patent number: 5421839
    Abstract: Antifungal polypeptide and process for its productionThe polypeptide with the sequence (SEQ ID NO: 1)Ala-Thr-Tyr-Asn-Gly-Lys-Cys-Tyr-Lys-Lys-Asp-Asn-Ile-Cys-Lys-Tyr-Lys-Ala-Gln -Ser-Gly-Lys-Thr-Ala-Ile-Cys- Lys-Cys-Tyr-Val-Lys-Lys-Cys-Pro-Arg-Asp-Gly-Ala-Lys-Cys-Glu-Phe-Asp-Ser-Ty r-Lys-Gly-Lys-Cys-Tyr-Cyscan be produced by the fermentation of Aspergillus giganteus and used as an antifungal agent.Expression of this polypeptide gene in plants strongly inhibits the growth of phytopathogenic fungi on the plant.
    Type: Grant
    Filed: October 30, 1992
    Date of Patent: June 6, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Norbert Ulbrich, Rolf Hilgenfeld, Heinz Hanel, Burkhard Sachse, Peter Braun, Joachim Wink, Peter Eckes, Jurgen Logemann, Jozef Schell