Patents by Inventor Rolf Horlein

Rolf Horlein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of cephem prodrug esters
    Patent number: 5637721
    Abstract: The invention relates to a process which comprises a compound of the formula II ##STR1##
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 10, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Elisabeth Defossa, Gerd Fischer, Uwe Gerlach, Rolf Horlein, Norbert Krass, Rudolf Lattrell, Ulrich Stache, Theodor Wollmann
  • Process for the preparation of cephem prodrug esters
    Patent number: 5589594
    Abstract: The invention relates to a process for the preparation of cephem prodrug esters of the formula: ##STR1## in which R.sup.1 is C.sub.1 -C.sub.5 -alkanoyloxy-C.sub.1 -C.sub.3 -alkyl or C.sub.1 -C.sub.5 -alkoxycarbonyloxy-C.sub.1 -C.sub.3 -alkyl and X is an inorganic or organic anion, and in which the hydroxyimino group is present in the syn-form.
    Type: Grant
    Filed: December 30, 1993
    Date of Patent: December 31, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Elisabeth Defossa, Gerd Fischer, Uwe Gerlach, Rolf Horlein, Norbert Krass, Rudolf Lattrell, Ulrich Stache, Theodor Wollmann
  • Diastereomers of 1-(isopropoxycarbonyloxy)ethyl 3-cephem-4-carboxylate
    Patent number: 5461043
    Abstract: Enterally absorbable diastereomers of 1-(isopropoxycarbonyloxy)ethyl (6R,7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-3-(metho xymethyl)-3-cephem-4-carboxylate of the formula I ##STR1## and their physiologically acceptable salts and also diastereomerically pure salts of the compounds of the formula II ##STR2## where HX is a mono- or polybasic acid and where X is an inorganic or organic physiologically acceptable anion, and a process for the preparation of these compounds of the formula I or II, which comprises first precipitating the more sparingly soluble diastereomer of the formula IV in the mixing together of 1 equivalent of a solution of the diastereomer mixture of the formula III with 0.
    Type: Grant
    Filed: September 3, 1992
    Date of Patent: October 24, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerd Fischer, Elisabeth Defossa, Uwe Gerlach, Rolf Horlein, Norbert Krass, Rudolf Lattrell, Ulrich Stache, Theodor Wollmann, Dieter Isert
  • Tetracyclic antibiotics and processes for their preparation
    Patent number: 5405844
    Abstract: Tetracyclic antibiotics and processes for their preparation .beta.-Lactam antibiotics of the formula I, and their pharmaceutically tolerable salts ##STR1## where X is (CH.sub.2).sub.0-2, CR(a)R(b), O, SO.sub.0-2 or NR(c),R1, R2 and R3 are a multiplicity of substituents, are outstanding antibiotics with remarkably good antibacterial activity both against gram-positive and against gram-negative microorganisms. They have a high stability to renal dehydropeptidase.
    Type: Grant
    Filed: May 28, 1992
    Date of Patent: April 11, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Uwe Gerlach, Rolf Horlein, Norbert Krass, Rudolf Lattrell, Theo Wollmann, Michael Limbert, Astrid Markus
  • Process for the preparation of penem compounds
    Patent number: 5198544
    Abstract: Compound I ##STR1## is obtained by reaction of compound II with compound III
    Type: Grant
    Filed: February 25, 1991
    Date of Patent: March 30, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Karl-Heinz Budt, Walter Durokheimer, Gerd Fischer, Rolf Horlein, Reiner Kirrstetter, Rudolf Lattrell