Patents by Inventor Rolf I. Carlson

Rolf I. Carlson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-CHI3L1 antibodies for the detection and/or treatment of nonalcoholic fatty liver disease/nonalcoholic steatonhepatitis and subsequent complications
    Patent number: 12012465
    Abstract: The present disclosure relates to antibodies that bind human chitinase-3-like protein 1 (CHI3L1) and uses thereof. In aspects, the antibodies are useful in compositions and methods for detecting and/or treating nonalcoholic steatohepatitis (NAFLD) or nonalcoholic fatty liver disease (NASH) in a subject, as well as subsequent complications of untreated progression in the liver of a subject, such as liver cirrhosis and/or a hepatocellular carcinoma.
    Type: Grant
    Filed: September 22, 2021
    Date of Patent: June 18, 2024
    Assignee: RHODE ISLAND HOSPITAL
    Inventors: Jack R. Wands, Rolf I. Carlson
  • ANTI-CHI3L1 ANTIBODIES FOR THE DETECTION AND/OR TREATMENT OF NONALCOHOLIC FATTY LIVER DISEASE/ NONALCOHOLIC STEATONHEPATITIS AND SUBSEQUENT COMPLICATIONS
    Publication number: 20220002440
    Abstract: The present disclosure relates to antibodies that bind human chitinase-3-like protein 1 (CHI3L1) and uses thereof. In aspects, the antibodies are useful in compositions and methods for detecting and/or treating nonalcoholic steatohepatitis (NAFLD) or nonalcoholic fatty liver disease (NASH) in a subject, as well as subsequent complications of untreated progression in the liver of a subject, such as liver cirrhosis and/or a hepatocellular carcinoma.
    Type: Application
    Filed: September 22, 2021
    Publication date: January 6, 2022
    Inventors: Jack R. Wands, Rolf I. Carlson
  • Anti-CHI3L1 antibodies for the detection and/or treatment of nonalcoholic fattly liver disease/nonalcoholic steatonhepatitis and subsequent complications
    Patent number: 11155638
    Abstract: The present disclosure relates to antibodies that bind human chitinase-3-like protein 1 (CHI3L1) and uses thereof. In aspects, the antibodies are useful in compositions and methods for detecting and/or treating nonalcoholic steatohepatitis (NAFLD) or nonalcoholic fatty liver disease (NASH) in a subject, as well as subsequent complications of untreated progression in the liver of a subject, such as liver cirrhosis and/or a hepatocellular carcinoma.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: October 26, 2021
    Assignee: RHODE ISLAND HOSPITAL
    Inventors: Jack R. Wands, Rolf I. Carlson
  • ANTI-CHI3L1 ANTIBODIES FOR THE DETECTION AND/OR TREATMENT OF NONALCOHOLIC FATTLY LIVER DISEASE/ NONALCOHOLIC STEATONHEPATITIS AND SUBSEQUENT COMPLICATIONS
    Publication number: 20210230302
    Abstract: The present disclosure relates to antibodies that bind human chitinase-3-like protein 1 (CHI3L1) and uses thereof. In aspects, the antibodies are useful in compositions and methods for detecting and/or treating nonalcoholic steatohepatitis (NAFLD) or nonalcoholic fatty liver disease (NASH) in a subject, as well as subsequent complications of untreated progression in the liver of a subject, such as liver cirrhosis and/or a hepatocellular carcinoma.
    Type: Application
    Filed: May 7, 2019
    Publication date: July 29, 2021
    Inventors: Jack R. Wands, Rolf I. Carlson
  • TARGETING ASPARTATE BETA-HYDROXYLASE SUPPRESSES TUMOR MALIGNANCY AND METASTASIS
    Publication number: 20210052561
    Abstract: Disclosed are methods of treating a cell proliferative disease (e.g., cancer) by administering compounds which inhibit the activity of beta-hydroxylase (e.g., ASPH). Further disclosed are methods suppressing metastasis in a cancer cell by contacting the cancer cell with the compounds.
    Type: Application
    Filed: August 24, 2020
    Publication date: February 25, 2021
    Inventors: Jack R. Wands, Rolf I. Carlson, Mark Jon Olsen
  • DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS
    Publication number: 20100144837
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Application
    Filed: November 25, 2009
    Publication date: June 10, 2010
    Applicant: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS
    Publication number: 20100136581
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Application
    Filed: November 25, 2009
    Publication date: June 3, 2010
    Applicant: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Methods of inhibiting metastases
    Patent number: 7122541
    Abstract: The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue with Taurolidine.
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: October 17, 2006
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Rolf I. Carlson, Paul Maggio
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 7094556
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: August 22, 2006
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6815415
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: November 9, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6812206
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: November 2, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6797696
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: September 28, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6783758
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: August 31, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Methods of inhibiting metastases
    Patent number: 6753328
    Abstract: The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue with Taurolidine.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: June 22, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Rolf I. Carlson, Paul Maggio
  • Methods of inhibiting metastases
    Publication number: 20030069229
    Abstract: The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue with Taurolidine.
    Type: Application
    Filed: October 1, 2002
    Publication date: April 10, 2003
    Inventors: Jack R. Wands, Rolf I. Carlson, Paul Maggio
  • DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS
    Publication number: 20030031670
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Application
    Filed: November 8, 1999
    Publication date: February 13, 2003
    Inventors: JACK R. WANDS, SUZANNE M. DE LA MONTE, NEDIM INCE, ROLF I. CARLSON
  • Diagnosis and treatment of malignant neoplasms
    Publication number: 20020146421
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Application
    Filed: July 11, 2001
    Publication date: October 10, 2002
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms
    Publication number: 20020122802
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Application
    Filed: July 11, 2001
    Publication date: September 5, 2002
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms
    Publication number: 20020114811
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Application
    Filed: July 11, 2001
    Publication date: August 22, 2002
    Inventors: Jack R. Wands, Suzanne M. de la Mote, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms statement as to federally sponsored research
    Publication number: 20020114810
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Application
    Filed: July 11, 2001
    Publication date: August 22, 2002
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson