Patents by Inventor Rolf J. Craven

Rolf J. Craven has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nuclear tyrosine kinase Rak
    Patent number: 6531296
    Abstract: A nuclear tyrosine kinase called Rak has been identified. This tyrosine kinase is expressed primarily in epithelial cells, and has been found to be a growth inhibiting kinase. Domains of the Rak protein, and corresponding peptides, have been found to inhibit CDC2 function and therefore block the cell cycle and inhibit cell growth. A domain of the Rak protein which binds to the retinoblastoma gene product has also been identified, and is in a domain distinct from the CDC2 binding region. Peptides which bind to CDC2, and peptides which bind to the retinoblastoma gene product, are described.
    Type: Grant
    Filed: June 20, 1995
    Date of Patent: March 11, 2003
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Edison T. Liu, Rolf J. Craven, William G. Cance