Abstract: The present invention relates to a molecular assembly on a substrate usable for studying and/or performing biological interactions and/or reactions The invention further relates to an in vitro method to provide a substrate with a heparin coating presenting biotinylated biomolecules comprising linking avidin to a surface capable of binding avidin. A heparin conjugate is then linked to the avidin treated surface to form a layer of heparin thereon. Finally, a biotinylated biological probe or biomolecule is linked to the avidin through the layer of heparin thereby forming an essentially biologically inert surface with biotinylated probes extending out from the surface.

Abstract: The present invention discloses an in vitro method to provide biological tissue with a heparin coating comprising the following steps; linking a biotin reagent to biological tissue, linking an avidin reagent to the biotinylated biological tissue, and linking a heparin reagent to the formed layer of avidin on the biological tissue thus forming a heparin coating. The invention further discloses a heparin coating on biological tissue, the use of a heparin coating, and the biological tissue coated with a heparin layer according to the method.

Abstract: Welding head 1 for friction stir welding, adapted for connection and driving of a tool 2 intended for simultaneous friction stir welding from two opposite surfaces on an object for welding, comprising a tool holder 9, a force-generating device 3, 13 and a rotary driving device 5 which, during operation, can impart to the connected tool 2 a cyclic movement around the centre axis 10 of the tool and relative to the object for welding arranged in conjunction with the welding head. The force-generating device is controllable during operation and adapted so as, during operation, to act between a primary shoulder 6 and a secondary shoulder 7 on a tool 2 connected in the tool holder 9. The invention also comprises a welding system for friction stir welding, with the force between the shoulders of the tool being controlled depending on the current torque for rotary driving. Also indicated are a method for initiating friction stir welding and computer program for such a method.

Abstract: A stent assembly (2) includes a stent capable of assuming a contracted and an expanded configuration. A membrane of a biocompatible material impermeable to molecular transport across the membrane is wrapped around the stent more than one full turn. There is also disclosed a device for performing anastomosis, including a stent assembly (2) in a contracted state and a holding and gripping device (12). The handle has a handle portion (14) and a support structure (16, 18) for accommodating the stent assembly. There is a locking loop (20) that can be tightened around the stent assembly when it is positioned on the support structure, and released to allow the stent assembly to expand to a nominal size.

Abstract: The invention refers to new alkylating di- and tripeptides based on a melphalan unit, and one or two additional amino acids or amino acid derivatives, which can be used in the treatment of carcinogenic diseases. Further, the invention refers to a pharmaceutical composition comprising the alkylating peptides of the invention.

Abstract: Welding head 1 for friction stir welding, adapted for connection and driving of a tool 2 intended for simultaneous friction stir welding from two opposite surfaces on an object for welding, comprising a tool holder 9, a force-generating device 3, 13 and a rotary driving device 5 which, during operation, can impart to the connected tool 2 a cyclic movement around the centre axis 10 of the tool and relative to the object for welding arranged in conjunction with the welding head. The force-generating device is controllable during operation and adapted so as, during operation, to act between a primary shoulder 6 and a secondary shoulder 7 on a tool 2 connected in the tool holder 9. The invention also comprises a welding system for friction stir welding, with the force between the shoulders of the tool being controlled depending on the current torque for rotary driving. Also indicated are a method for initiating friction stir welding and computer program for such a method.

Abstract: The invention relates to a welding apparatus comprising a welding unit, a work-table for supporting the workpieces to be welded, and the clamping means for clamping the workpieces to the work-table in the direction towards one another during the welding operation. The welding unit comprises a friction stir welding head and a fusion welding head.

Abstract: The invention refers to new alkylating di- and tripeptides based on a melphalan unit, and one or two additional amino acids or amino acid derivatives, which can be used in the treatment of carcinogenic diseases. Further, the invention refers to a a pharmaceutical composition comprising the alkylating peptides of the invention.

Abstract: The invention concerns an apparatus for friction stir welding, comprising a welding unit including a welding head, a worktable including a backing unit to support the workpieces to be welded together along their joint line, and clamping means to clamp the workpieces to the worktable in a direction towards one another during the welding operation. The backing unit consists of at least two backing parts or of at least one backing part and one additional welding head, said backing parts being freely exchangeable, one for the other, before each welding operation as is also each backing part freely exchangeable for the additional welding head, and vice versa.

Abstract: A plant for friction stir welding, comprising a welding probe, a drive unit driving the welding probe, a work table supporting the workpiece or workpieces to be welded, and at least one clamping means for clamping the workpieces to one another or to the work table, or the workpieces to the work table, respectively, during the welding operation. The plant likewise comprises a milling tool.

Abstract: The invention relates to a welding assembly for joining together workpieces (1, 2) along a joint between said pieces by means of friction stir welding. The welding assembly comprises a welding probe (9) intended to be advanced along said joint during the welding operation. The welding probe comprises a body (10) and a pin (20), the body being arranged to be pressed against the upper faces of the workpieces during the welding operation whereas the pin is arranged to be moved along said joint during the welding while being rotated and pressed against said workpieces. The pin (20) and the body (10) are also so arranged relative to one another as to be mutually movable, allowing said pin and said body to perform different movement patterns relative to one another.

Abstract: A method for contactless inductive transmission of programming data to a programmable time fuse included in a shell for a single shot, semi-automatic, or fully automatic shell firing barrel weapon. While the shell is situated in a cartridge chamber of a barrel of the weapon, data is transmitted to the programmable time fuse from a programming device of the weapon via a transmitting coil arranged around the cartridge chamber of the barrel to a receiving coil arranged in the shell. At least a part of the barrel lying between the coils is replaced by a non-magnetic material and designed so that it does not form an electrically conductive short circuited layer that would prevent transmission between the coils.

Abstract: A shell-firing barrel weapon system for a single shot, semi-automatic or fully automatic firing, including a rifled barrel comprising a programming member for programming with programming pulses fuses in shells fired from the weapon before or in conjunction with firing of the shells. At least one contact is located in the barrel of the weapon and connected to the programming member for transmitting a programming pulse from the programming member to the fuses of the shells. The at least one contact is electrically insulated from the barrel and protrudes into the barrel beyond bars of rifling of the barrel. An electrically conductive contact ring is concentrically arranged on the shells. The contact ring is electrically insulated from main parts of the shells and has an external diameter that is smaller than a diameter of the bars of the rifling of the barrel.

Abstract: A device for welding together elongated work pieces such as railroad track, is provided with controls to eliminate pre-existing angles that exist between each work piece prior to joining.

Abstract: In a procedure for flushing a catheter, connected to an apparatus, implanted in a patient for infusing liquid medication, in particular insulin, through the catheter, the infusion channel in the catheter is isolated from the patient and connected in a circuit separated from the patient. Cleaning fluid is then flushed through the circuit. In a device for flushing a catheter according to this procedure, connected to an implanted apparatus for infusing fluid medication, in particular insulin, through the catheter, the catheter is at least of a double-lumen type. One channel is intended for the infusion of the medication through an outlet valve in the catheter, and a second valve is arranged in the tip of the catheter to interconnect the two channels.

Abstract: A coupling for selectively connecting a plurality of conduits running to a common connection point, for controlling flows for medical purposes, includes a coupling element having one or more passages which, by rotation and/or displacement of the coupling element, are connectable to selected conduits for selective connection of the selected conduits at the same time as other conduits running to the connection point are closed by the coupling element so as to determine a flow path. The coupling element may be formed by a cannula, or alternatively may be formed by a coupling cone or element maneuverable by a cannula. In a restriction device for a conduit for carrying a fluid, especially for medical purposes, a first tube is connected to a channel extended through an elastic body. The body is surrounded by a stiff sleeve.

Abstract: The present invention relates to a water-soluble conjugate having antithrombin-binding activity comprising a substantially straight-chained organic polymer backbone having at least 30 molecules of sulfated glycosaminoglycans distributed along the polymer backbone, wherein the sulfated glycosaminoglycans are attached to the polymer backbone at a single point of attachment which is not responsible for the antithrombin-binding activity. The present invention also relates to a surface having antithrombin-binding properties prepared with the conjugate and methods of preparing said conjugate and said surface.

Abstract: The present invention relates to a device for retaining knife blades for cutting, perforation or other treatment of a running web, preferably a paper web. The web runs between a rotatable knife-retaining cylinder and a counter pressure cylinder, whereby the knife blade may be wedged up by a wedge device by being brought into the slot by the counter pressure cylinder. In order to permit effective wedging up of knife blades in exact positions in the slot, even when the blades have dimensions which differ from knife blades of the certain defined dimension, the wedge device comprises and/or cooperates with at least one spring disposed beside the wedge device in the slot, upon insertion of a knife blade into the slot for wedging up thereof by the counter pressure cylinder.

Abstract: The present invention relates to a device for retaining knife blades for cutting, perforation or other treatment of a running web, preferably a paper web, whereby the web (4) runs between a rotatable knife retaining cylinder (3) and a rotatable counter pressure cylinder (5) and whereby the knife blade (2) and a retaining ruler (7) for retaining the blade (2) are provided in a slot (6) in the knife retaining cylinder (3).

Abstract: A surface modified substrate, wherein the substrate carries a complex adsorbed thereto, which complex is of a polymeric cationic surfactant that contains primary amino nitrogens as well as secondary and/or tertiary amino nitrogens, and a dialdehyde that has 1-4 carbon atoms between the two aldehyde groups. To said complex there may additionally be bonded an anionic compound and optionally alternatingly additional cationic and anionic compounds. The modification primarily means that positive or negative charges can be imparted to the original substrate. Secondly, however, the point may be to utilize reactive groups in bonded cationic or anionic compounds.