Patents by Inventor Rolf Lohrmann
Rolf Lohrmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7227430Abstract: A bondwire transition arrangement for interconnecting a signal port on one IC of a multichip module with a signal port on another, adjacent, IC of the same module employs a distributed signal-transition process in which the signal on one port appears as subsignals at tapping points along a series transmission-line segment arrangement between that port and ground on the same IC and the subsignals are recombined along a second series transmission-line segment arrangement connected between the other port and ground on the other IC. Spatially corresponding tapping points are interconnected via bondwires.Type: GrantFiled: October 28, 2002Date of Patent: June 5, 2007Assignee: Marconi Communications GmbHInventors: Hardial Singh Gill, Stefan Koch, Rolf Lohrmann
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Publication number: 20050083150Abstract: A bondwire transition arrangement for interconnecting a signal port on one IC of a multichip module with a signal port on another, adjacent, IC of the same module employs a distributed signal-transition process in which the signal on one port appears as subsignals at tapping points along a series transmission-line segment arrangement between that port and ground on the same IC and the subsignals are recombined along a second series transmission-line segment arrangement connected between the other port and ground on the other IC. Spatially corresponding tapping points are interconnected via bondwires.Type: ApplicationFiled: October 28, 2002Publication date: April 21, 2005Inventors: Hardial Gill, Stefan Koch, Rolf Lohrmann
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Patent number: 6193953Abstract: Microparticles useful for enhancing the ultrasound image of a tissue or organ consist of liquid and/or gas core material which is encapsulated by a biocompatible, tanned protein shell. These stabilized microparticles are useful as ultrasonic imaging agents, and are additionally useful in the further production of functionalized microparticles for in vivo imaging. In particular, targeting molecules such as antibodies or other ligands can be attached to the strengthened exterior surface of the stabilized microparticles to impart target-specificity to the microparticles. The targeting molecules may also provide hydrophilicity to the exterior surface, thus increasing the recirculation time of the microparticles. The targeting molecules may be attached directly to the exterior surface of the microparticles, or they may be attached via a bifunctional spacer arm, which may itself be hydrophilic.Type: GrantFiled: March 8, 2000Date of Patent: February 27, 2001Assignee: Molecular Biosystems, Inc.Inventors: Rolf Lohrmann, Brent Lee Golec
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Patent number: 6083484Abstract: Microparticles useful for enhancing the ultrasound image of a tissue or organ consist of liquid and/or gas core material which is encapsulated by a biocompatible, tanned protein shell. These stabilized microparticles are useful as ultrasonic imaging agents, and are additionally useful in the further production of functionalized microparticles for in vivo imaging. In particular, targeting molecules such as antibodies or other ligands can be attached to the strengthened exterior surface of the stabilized microparticles to impart target-specificity to the microparticles. The targeting molecules may also provide hydrophilicity to the exterior surface, thus increasing the recirculation time of the microparticles. The targeting molecules may be attached directly to the exterior surface of the microparticles, or they may be attached via a bifunctional spacer arm, which may itself be hydrophilic.Type: GrantFiled: October 16, 1997Date of Patent: July 4, 2000Assignee: Molecular Biosystems, Inc.Inventors: Rolf Lohrmann, Brent Lee Golec
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Patent number: 6063362Abstract: The present invention relates to a process for making insoluble gas-filled, pressure-resistant microspheres containing a liquid or solid hydrophobic barrier within the microsphere shell, and products of this process. This barrier serves to decrease the rate of gas exchange between the microsphere and the aqueous environment surrounding the microsphere and thus enhances resistance to pressure due to gas exchange.Type: GrantFiled: January 20, 1998Date of Patent: May 16, 2000Assignee: Molecular Biosystems, Inc.Inventor: Rolf Lohrmann
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Patent number: 6030603Abstract: This invention relates to an oil-in-water emulsion that is of a water-insoluble gas-forming chemical and a stabilizer. The emulsion being capable of forming microbubbles of gas upon application of ultrasonic energy. This composition allows for site specific imaging as the image enhancing microbubbles can be released upon the application of ultrasonic energy at the specific location where the image is desired.Type: GrantFiled: December 23, 1997Date of Patent: February 29, 2000Assignee: Molecular Biosystems, Inc.Inventors: Rolf Lohrmann, Kenneth J. Widder, Ashwin M. Krishnan, Dung Kevin Hong, Jialun Meng
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Patent number: 5965109Abstract: The present invention relates to a process for making insoluble gas-filled, pressure-resistant microspheres containing a liquid or solid hydrophobic barrier within the microsphere shell, and products of this process. This barrier serves to decrease the rate of gas exchange between the microsphere and the aqueous environment surrounding the microsphere and thus enhances resistance to pressure due to gas exchange.Type: GrantFiled: November 17, 1997Date of Patent: October 12, 1999Assignee: Molecular Biosystems, Inc.Inventor: Rolf Lohrmann
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Patent number: 5855865Abstract: Elastic protein microspheres, filled with water insoluble gases, have been produced by ultrasound and mechanical cavitation without the present of oxygen. The microspheres are highly echogenic. The microspheres exhibit greatly enhanced static pressure stability, up to 40 psig. The microspheres are resistant to coalescence and to expansion due to differential gas diffusion. The microspheres are resistant to collapse when suspended in a gas-depleted aqueous solution.Type: GrantFiled: July 2, 1997Date of Patent: January 5, 1999Assignee: Molecular Biosystems, Inc.Inventors: Karel J. Lambert, Sheila Benay Podell, Edward G. Jablonski, Carl Hulle, Kenneth Hamilton, Rolf Lohrmann
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Patent number: 5846515Abstract: Calixarene conjugates useful for imaging, particularly magnetic resonance imaging (MRI) and computed tomography (CT) are described. Said calixarene conjugates comprise (i) a calixarene backbone, and (ii) at least one imaging moiety linked thereto, and may be of the formula: ##STR1## wherein at least one of the R.sup.1 and R.sup.4 substituents comprises an imaging moiety, the remaining R.sup.1 and R.sup.4 substituents are spectator groups, J is an ortho-linker, and n is an integer from 4 to 8. Imaging moieties useful for CT imaging include those comprising two or more iodine atoms. Imaging moieties useful for MRI include (i) organic moieties comprising four or more fluorine atoms; (ii) nitroxyl spin labeled moieties; and (iii) metal chelate moieties.Type: GrantFiled: November 7, 1996Date of Patent: December 8, 1998Assignee: Molecular Biosystems, Inc.Inventors: Ashwin M. Krishnan, Rolf Lohrmann
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Patent number: 5820850Abstract: The present invention relates to gas-filled microspheres useful as ultrasound contrast agents. More particularly, the present invention relates to gas-filled microspheres prepared from amphiphilic poly amino acid block co-polymers and a pharmacologically acceptable water-insoluble gas. The hydrophobic block of the co-polymer is formed from amino acids possessing hydrophobic side-chains, for example, leucine, isoleucine, valine, and phenylalanine, and the hydrophilic block of the co-polymer is formed from amino acids possessing hydrophilic side-chains, for example, glutamic acid (and its ionized form, glutamate), aspartic acid (and its ionized form, aspartate), and lysine.Type: GrantFiled: June 7, 1995Date of Patent: October 13, 1998Assignee: Molecular Biosystems, Inc.Inventors: Yukio Hashimoto, Rolf Lohrmann
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Patent number: 5730955Abstract: A process for making gas-filled, pressure-resistant microspheres containing a liquid or solid hydrophobic barrier within the microsphere shell.Type: GrantFiled: June 7, 1995Date of Patent: March 24, 1998Assignee: Molecular Biosystems, Inc.Inventor: Rolf Lohrmann
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Patent number: 5716597Abstract: This invention relates to an oil-in-water emulsion that is of a water-insoluble gas-forming chemical and a stabilizer. The emulsion being capable of forming microbubbles of gas upon application of ultrasonic energy. This composition allows for site specific imaging as the image enhancing microbubbles can be released upon the application of ultrasonic energy at the specific location where the image is desired.Type: GrantFiled: June 4, 1993Date of Patent: February 10, 1998Assignee: Molecular Biosystems, Inc.Inventors: Rolf Lohrmann, Kenneth J. Widder, Ashwin M. Krishnan, Dung Kevin Hong, Jialun Meng
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Patent number: 5660815Abstract: The present invention relates to improved imaging agents useful for .sup.19 F magnetic resonance imaging (MRI). More particularly, the present invention relates to fluorinated fatty acid sulfonate derivatives, such as those derived by reaction of fluorinated fatty acids with sulfonated compounds such as taurine analogs or isethionic acid analogs, which offer improved water solubility and biocompatibility.Type: GrantFiled: April 28, 1995Date of Patent: August 26, 1997Assignee: Molecular Biosystems, Inc.Inventors: Rolf Lohrmann, Ashwin Krishnan
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Patent number: 5654452Abstract: Aromatic acid-derived lipophilic polyhalogenated compounds are provided for use as contrast agents in diagnostic imaging or as therapeutic agents. These compounds are particularly useful when incorporated into an oil-in-water emulsion for tissue-specific delivery to the liver. For hepatocyte-selective delivery, the emulsion is chylomicron remnant-like by being in a size range of 50 to 200 nm and having a composition simulating naturally-occuring chylomicron remnants.Type: GrantFiled: June 7, 1995Date of Patent: August 5, 1997Assignee: Molecular Biosystems, Inc.Inventors: Rolf Lohrmann, Dung K. Hong
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Patent number: 5622687Abstract: Calixarene conjugates useful for imaging, particularly magnetic resonance imaging (MRI) and computed tomography (CT) are described. Said calixarene conjugates comprise (i) a calixarene backbone, and (ii) at least one imaging moiety linked thereto, and may be of the formula: ##STR1## wherein at least one of the R.sup.1 and R.sup.4 substituents comprises an imaging moiety, the remaining R.sup.1 and R.sup.4 substituents are spectator groups, J is an ortho-linker, and n is an integer from 4 to 8. Imaging moieties useful for CT imaging include those comprising two or more iodine atoms. Imaging moieties useful for MRI include (i) organic moieties comprising four or more fluorine atoms; (ii) nitroxyl spin labeled moieties; and (iii) metal chelate moieties.Type: GrantFiled: November 15, 1994Date of Patent: April 22, 1997Assignee: Molecular Biosystems, Inc.Inventors: Ashwin M. Krishnan, Rolf Lohrmann
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Patent number: 5562893Abstract: Improved ultrasonic imaging contrast agents are provided which are comprised of an aqueous suspension of microspheres comprising at least one gas, preferably a perfluorocarbon, encapsulated by elastic shells of a biocompatible, fluorine-containing amphiphilic material, processes for making the microspheres, and methods of diagnostic imaging using the improved contrast agents.Type: GrantFiled: August 2, 1994Date of Patent: October 8, 1996Assignee: Molecular Biosystems, Inc.Inventor: Rolf Lohrmann
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Patent number: 5536489Abstract: This invention relates to an oil-in-water emulsion that is of a water-insoluble gas-forming chemical and a stabilizer. The emulsion being capable of forming microbubbles of gas upon application of ultrasonic energy. This composition allows for site specific imaging as the image enhancing microbubbles can be released upon the application of ultrasonic energy at the specific location where the image is desired.Type: GrantFiled: May 12, 1995Date of Patent: July 16, 1996Assignee: Molecular Biosystems, Inc.Inventors: Rolf Lohrmann, Kenneth J. Widder, Ashwin M. Krishnan, Dung K. Hong, Jialun Meng
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Patent number: 5401493Abstract: Organic compounds for diagnostic imaging which contain at least one aryl group which has been derivatized to contain at least one perfluoro-1H,1H-neopentyl moiety are provided. The perfluoro-1H,1H-neopentyl groups produce a single magnetic resonance to insure a maximum signal to noise ratio. One compound disclosed is 2-O-oleoylglycerol 1,3-bis(7'-{3",5"-di[2"',2"'-di(trifluoromethyl)3"', 3"',3"'-trifluoropropyl]phenyl}heptanoate). In the preferred embodiment, a lipid emulsion is provided as a carrier vehicle to deliver the derivitized analog to a mammalian recipient. Methods to use these compounds in MRI and computerized tomography are provided.Type: GrantFiled: March 26, 1993Date of Patent: March 28, 1995Assignee: Molecular Biosystems, Inc.Inventors: Rolf Lohrmann, Ashwin Krishnan