Abstract: The present invention relates to a method for administering water soluble physiologically active substances, said method comprising intranasally administering to a subject an aqueous composition comprising 0.001-25 wt. % of one or more fully dissolved physiologically active substances, the physiologically active substances having a water solubility in demineralized water of at least 15 mg/mL at 20° C. of, 0.01-10 wt. % nicotinamide, and at least 60 wt. % water. The invention also relates to a kit comprising said composition and to the use of nicotinamide as an enhancer of intranasal absorption of a physiologically active substance from an aqueous solution, wherein the aqueous solution further comprises 0.01-10 wt. % nicotinamide.

Abstract: The present invention relates to a method for administering water soluble physiologically active substances, said method comprising intranasally administering to a subject an aqueous composition comprising 0.001-25 wt. % of one or more fully dissolved physiologically active substances, the physiologically active substances having a water solubility in demineralized water of at least 15 mg/mL at 20° C. of, 0.01-10 wt. % nicotinamide, and at least 60 wt. % water. The invention also relates to a kit comprising said composition and to the use of nicotinamide as an enhancer of intranasal absorption of a physiologically active substance from an aqueous solution, wherein the aqueous solution further comprises 0.01-10 wt. % nicotinamide.

Abstract: The present invention relates to a nebulizer, such as a spray can, for the topical application of a liquid and/or solid to a surface. The nebulizer is characterized by a valve comprising a mixing chamber designed for forming a colloidal mixture comprising a dispersed phase consisting of a liquid and/or a solid substance and a continuous phase consisting of a propellant gas before delivering the colloidal mixture to the nozzle. The invention also relates to a method for the topical cooling of the skin of a person or animal. In addition, the invention relates to various other uses of the device.

Abstract: The present invention relates to a nebulizer, such as a spray can, for the topical application of a liquid and/or solid to a surface. The nebulizer is characterized by a valve comprising a mixing chamber designed for forming a colloidal mixture comprising a dispersed phase consisting of a liquid and/or a solid substance and a continuous phase consisting of a propellant gas before delivering the colloidal mixture to the nozzle. The invention also relates to a method for the topical cooling of the skin of a person or animal. In addition, the invention relates to various other uses of the device.