Patents by Inventor Rolf Muller

Rolf Muller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11865541
    Abstract: The presently disclosed subject matter provides dual-depth thermoplastic microfluidic devices, related kits, microfluidic systems comprising the dual-depth thermoplastic microfluidic device, methods of isolating nucleic acid analytes from a liquid sample, and methods of isolating extracellular vesicles from a liquid sample.
    Type: Grant
    Filed: December 12, 2022
    Date of Patent: January 9, 2024
    Assignee: BioFluidica, Inc.
    Inventors: Rolf Muller, Mateusz Hupert
  • Publication number: 20230384337
    Abstract: The presently disclosed subject matter provides methods of isolating fetal cells from a sample from a pregnant subject, methods of isolating multinucleated fetal giant cells from a sample from a pregnant subject, and related compositions and methods.
    Type: Application
    Filed: July 26, 2023
    Publication date: November 30, 2023
    Inventors: Rolf Muller, Judy Muller-Cohn, Philip D. Buchanan, Jiri Sonek, Kulvinder Kaur, Jennifer Barber-Singh, Paul Diaz
  • Publication number: 20230363375
    Abstract: Provided herein are formulations and methods for the stabilization of one or more thrombocytes at ambient temperatures. Also provided are formulations and methods for the stabilization of one or more thrombocytes in an inactivated state in a blood sample at ambient temperatures. Further provided are articles of manufacture and kits and methods for substantially stable storage of one or more thrombocyte at ambient temperatures.
    Type: Application
    Filed: May 26, 2023
    Publication date: November 16, 2023
    Inventors: Rolf MULLER, Joel DESHARNAIS, Steven P. WILKINSON, Victoria ARENDT, Paul DIAZ
  • Publication number: 20230211342
    Abstract: The presently disclosed subject matter provides dual-depth thermoplastic microfluidic devices, related kits, microfluidic systems comprising the dual-depth thermoplastic microfluidic device, methods of isolating nucleic acid analytes from a liquid sample, and methods of isolating extracellular vesicles from a liquid sample.
    Type: Application
    Filed: December 12, 2022
    Publication date: July 6, 2023
    Inventors: Rolf Muller, Mateusz Hupert
  • Patent number: 11672247
    Abstract: Provided herein are formulations and methods for the stabilization of one or more thrombocytes at ambient temperatures. Also provided are formulations and methods for the stabilization of one or more thrombocytes in an inactivated state in a blood sample at ambient temperatures. Further provided are articles of manufacture and kits and methods for substantially stable storage of one or more thrombocyte at ambient temperatures.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: June 13, 2023
    Assignee: Biomatrica, Inc.
    Inventors: Rolf Muller, Joel Desharnais, Steven P. Wilkinson, Victoria Arendt, Paul Diaz
  • Patent number: 11420521
    Abstract: A method of operating a battery system for providing electric energy to a vehicle. Sensor signals representing physical quantities of individual cells and/or individual modules of at least one battery of the battery system are generated. The sensor signals are transferred to a first and a second system controller. Both the first and second system controller evaluates the sensor signals and controls the battery system, depending on corresponding evaluation results. The first system controller is operated in combination with a first monitoring device and the second system controller is operated in combination with a second monitoring device. The first monitoring device monitors an operation of the second system controller and the second monitoring device monitors an operation of the first system controller. Depending on monitoring results of the first monitoring device and of the second monitoring device, the battery system is controlled.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: August 23, 2022
    Assignee: Bombardier Transportation GmbH
    Inventor: Rolf Müller
  • Patent number: 11365201
    Abstract: The present invention relates to novel chlorotonil derivatives of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections and malaria.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: June 21, 2022
    Assignee: Helmholtz-Zentrum Für Infektionsforschung GmbH
    Inventors: Antione Abou Fayad, Jennifer Herrmann, Katrin Jungmann-Sahner, Rolf Müller, Kathrin Mohr, Steffen Bernecker, Stephan Hüttel, Rolf Jansen, Emilia Oueis, Anastasia Andreas
  • Patent number: 11357752
    Abstract: Chemical compounds are provided that are useful in the treatment of diseases associated with an activity of a 5,10-methylenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase enzyme in pathological eukaryotic cells. In particular, compounds that exhibit inhibitory activity upon 5,10-methylenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase enzymes and their use in the treatment of cancer and/or parasitic diseases are provided.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: June 14, 2022
    Assignee: HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
    Inventors: Chengzhang Fu, Rolf Muller, Jannik Donner, Michael Reck, Irene Wagner-Dobler, Andreas Kirschning, Jonas Ammermann
  • Patent number: 11225503
    Abstract: The present invention provides cystobactamides of formula (I): R1—Ar1-L1-Ar2-L2-Ar3-L3-Ar4-L4-Ar5—R2 and the use thereof for the treatment or prophylaxis of bacterial infections.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: January 18, 2022
    Assignee: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH
    Inventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf W. Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Huettel
  • Publication number: 20210371426
    Abstract: The present invention relates to novel chlorotonil derivatives of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections and malaria.
    Type: Application
    Filed: November 7, 2018
    Publication date: December 2, 2021
    Inventors: Antione Abou Fayad, Jennifer Herrmann, Katrin Jungmann-Sahner, Rolf Müller, Kathrin Mohr, Steffen Bernecker, Stephan Hüttel, Rolf Jansen, Emilia Oueis, Anastasia Andreas
  • Publication number: 20210370106
    Abstract: A filter unit (100) is configured to filter a gas and/or particles out of a gas mixture, especially out of breathing air. A process is provided for manufacturing such a filter unit. A shell surface (M) of a rigid filter (1), for example, including activated carbon, is enclosed by a flexible jacket (3). The jacket is enclosed with a rigid cover (2, 5) at the outflow-side end. The process includes inserting the filter into a shaping body, so that a gap remains between the inner wall of the shaping body and the shell surface (M) of the filter. Free-flowing material is inserted into this gap, and this material forms the jacket after a curing. A second manufacturing process includes cutting a piece off from a tube and pulling over the shell surface (M) of the filter. The piece of tube then forms the jacket of the filter.
    Type: Application
    Filed: May 27, 2021
    Publication date: December 2, 2021
    Inventors: Ludwig LORENZEN, Rolf MÜLLER, Andreas JUNK, Sören KIRMSE, Tim ERHARDT
  • Patent number: 11160760
    Abstract: A method for producing starch soft capsules comprises the following steps: preparing a mixture comprising starch, plasticizer and water, wherein more than 50 weight percent of the starch is present in the form of particles of granular starch; shaping the mixture to form a film in a shaping process; solidifying the mixture by increasing the temperature of the mixture during and/or after the shaping process by more than 5° C.; and shaping the film to form a soft capsule. Soft capsules produced by this method have starch particles bonded to one another. A device for performing this method comprises a shaping device to enable shaping of the starch material to form a film, and a heating device to perform a heat treatment to destructure the starch during and/or after the shaping. It comprises a rotary die device.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 2, 2021
    Assignee: INNOGEL AG
    Inventors: Rolf Muller, Federico Innerebner
  • Publication number: 20210186926
    Abstract: Chemical compounds are provided that are useful in the treatment of diseases associated with an activity of a 5,10-methylenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase enzyme in pathological eukaryotic cells.
    Type: Application
    Filed: June 1, 2018
    Publication date: June 24, 2021
    Applicant: Helmholtz-Zentrum für Infektionsforschung GmbH
    Inventors: Chengzhang FU, Rolf MULLER, Jannik DONNER, Michael RECK, Irene WAGNER-DOBLER, Andreas KIRSCHNING, Jonas AMMERRMANN
  • Patent number: 11034648
    Abstract: The present invention relates to novel derivatives of cystobactamides of formula (Ib) and the use thereof for the treatment or prophylaxis of bacterial infections.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: June 15, 2021
    Assignees: HELMHOLTZ-ZENTRUM FÜR, INFEKTIONSFORSCHUNG GMBH
    Inventors: Giambattista Testolin, Mark Brönstrup, Hans-Peter Prochnow, Jennifer Herrmann, Rolf Müller, Charlotte Grandclaudon, Tim Mollner, Antje Ritter
  • Publication number: 20210032684
    Abstract: Provided herein are formulations for the stabilization of one or more polypeptide or nucleic acid molecule in a native, non-denatured state at ambient temperatures. Also provided are compositions, articles of manufacture, kits and methods for substantially stable storage of one or more polypeptide or nucleic acid molecule in a native, non-denatured, and/or functionally active conformation substantially free on intracellular polypeptides and nucleic acids at ambient temperatures are provided. Also provided are formulations for the stabilization of one or more exosome at ambient temperatures, and compositions, articles of manufacture, kits and methods of use.
    Type: Application
    Filed: October 19, 2020
    Publication date: February 4, 2021
    Inventors: Rolf MULLER, Scott WHITNEY, Paul DIAZ
  • Publication number: 20210000103
    Abstract: The present invention relates to the stabilization of one or more metabolically-active cell in a blood sample at ambient temperatures. In particular, formulations, compositions, articles of manufacture, kits and methods for substantially stable storage of one or more metabolically-active cell in a blood sample at ambient temperatures are provided.
    Type: Application
    Filed: September 22, 2020
    Publication date: January 7, 2021
    Inventors: Rolf MULLER, Robyn RABAN, Scott WHITNEY, Paul DIAZ
  • Publication number: 20200392071
    Abstract: The present invention relates to the application of biosynthetic engineering for the heterologous expression of a gene cluster for the biosynthesis of tetracycline compounds, notably chelocardin and its analogues. More particularly, the present invention pertains to a gene cluster encoding polypeptides involved in tetracycline biosynthesis, which gene cluster is suitable for heterologous expression of the biosynthetic pathway in a host cell. The present invention further pertains to DNA construct s comprising the gene cluster, to recombinant heterologous host cell s comprising the gene cluster or the DNA construct, to processes for the biosynthetic production of a tetracycline compound employing such recombinant host cells, and to tetracycline compounds thereby produced. The present invention also pertains to fusion proteins which are useful in the production of tetracycline compounds.
    Type: Application
    Filed: December 21, 2018
    Publication date: December 17, 2020
    Inventors: Rolf MÜLLER, Tadeja LUKEZIC, Maja REMSKAR, Nestor ZABURANNYI, Chantal BADER, Asfandyar SIKANDAR, Jesko KÖHNKE
  • Publication number: 20200344999
    Abstract: Provided herein are formulations and methods for the stabilization of one or more thrombocytes at ambient temperatures. Also provided are formulations and methods for the stabilization of one or more thrombocytes in an inactivated state in a blood sample at ambient temperatures. Further provided are articles of manufacture and kits and methods for substantially stable storage of one or more thrombocyte at ambient temperatures.
    Type: Application
    Filed: July 17, 2020
    Publication date: November 5, 2020
    Inventors: Rolf MULLER, Joel DESHARNAIS, Steven P. WILKINSON, Victoria ARENDT, Paul DIAZ
  • Publication number: 20200331964
    Abstract: The present invention provides cystobactamides of formula (I): R1—Ar1-L1-Ar2-L2-Ar3-L3-Ar4-L4-Ar5—R2 and the use thereof for the treatment or prophylaxis of bacterial infections.
    Type: Application
    Filed: June 10, 2020
    Publication date: October 22, 2020
    Inventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf W. Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Huettel
  • Patent number: 10793600
    Abstract: The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: October 6, 2020
    Assignee: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH
    Inventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf W. Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Hüttel