Patents by Inventor Rolf Noreen
Rolf Noreen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7148243Abstract: Compounds of the formula I: wherein Rx is cyano or bromo; R1 is halo; R2 is C114 C3 alkyl, and pharmaceutically acceptable salts and prodrugs thereof have activity as antiretrovirals.Type: GrantFiled: September 12, 2002Date of Patent: December 12, 2006Assignee: Medivir ABInventors: Christer Sahlberg, Rolf Noreen, Marita Hogberg, Per Engelhardt
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Publication number: 20040116418Abstract: The present invention is directed to compounds, compositions and methods of inhibiting and treating HIV and related viruses, and methods for cocrystallizing reverse transcriptase in vitro, inhibition of the replication of HIV and related viruses thereof.Type: ApplicationFiled: December 1, 2003Publication date: June 17, 2004Applicant: Medivir ABInventors: Peter Thomas Lind, Rolf Noreen, John Michael Morin, Robert John Ternansky
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Patent number: 6610714Abstract: Compounds of the formula I: where; R1 is O, S; R2 is an optionally substituted nitrogen-containing heterocycle, wherein the nitrogen is located at the 2 position relative to the (thio)urea bond; R3 is H, C1-C3 alkyl, R4-R7 are independently selected from H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, haloC1-C6 alkyl, C1-C6 alkanoyl, haloC1-C6 alkanoyl, C1-C6 alkoxy, haloC1-C6 alkoxy, C1-C6 alkyloxy-C1-C6 alkyl, haloC1-C6 alkyloxy-C1-C6 alkyl hydroxy-C1-C6 alkyl, amino-C1-C6 alkyl, carboxy-C1-C6 alkyl, cyano-C1-C6 alkyl, amino, carboxy, carbamoyl, cyano, halo, hydroxy, keto; X is —(CR8R9)n— R8 and R9 are independently H, C1-C3 alkyl, OH or R8 and R9 together are ═O n is 1, 2 or 3 and prodrugs and pharmaceutically acceptable salts thereof, have utility as inhibitors of HIV-1 reverse transcriptase, particularly drug escape mutants.Type: GrantFiled: March 5, 2002Date of Patent: August 26, 2003Assignee: Medivir ABInventors: Christer Sahlberg, Dmitry Antonov, Hans Wallberg, Rolf Noréen
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Publication number: 20030119881Abstract: Compounds of the formula I: 1Type: ApplicationFiled: September 12, 2002Publication date: June 26, 2003Applicant: Medivir ABInventors: Christer Salhberg, Rolf Noreen, Marita Hogberg, Per Engelhardt
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Publication number: 20030092743Abstract: Compounds of the formula I: 1Type: ApplicationFiled: March 5, 2002Publication date: May 15, 2003Applicant: Medivir ABInventors: Christer Sahlberg, Dmitry Antonov, Hans Wallberg, Rolf Noreen
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Patent number: 6486183Abstract: Compounds of formula (I): wherein Rx is cyano or bromo; R1 is halo; R2 is C1-C3 alkyl, and pharmaceutically acceptable salts and prodrugs thereof have activity as antiretrovirals.Type: GrantFiled: November 13, 2000Date of Patent: November 26, 2002Assignee: Medivir ABInventors: Christer Salhberg, Rolf Noréen, Marita Högberg, Per Engelhardt
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Publication number: 20020132794Abstract: The present invention is directed to compounds, compositions and methods of inhibiting and treating HIV and related viruses, and methods for cocrystallizing reverse transcriptase in vitro, inhibition of the replication of HIV and related viruses thereof.Type: ApplicationFiled: February 13, 2002Publication date: September 19, 2002Applicant: MEDIVIR ABInventors: Peter Thomas Lind, Rolf Noreen, John Michael Morin, Robert John Ternansky
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Patent number: 6376492Abstract: The present invention is directed to compounds, compositions and methods of inhibiting and treating HIV and related viruses, and methods for cocrystallizing reverse transcriptase in vitro, inhibition of the replication of HIV and related viruses thereof.Type: GrantFiled: May 9, 2000Date of Patent: April 23, 2002Assignee: Medivir ABInventors: Peter Thomas Lind, Rolf Noréen, John Michael Morin, Robert John Ternansky
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Patent number: 5849769Abstract: A method for treating HIV which comprises a compound of the formula ##STR1## wherein A is ##STR2## and Z.sub.i is O, Se, NR.sup.a or C(R.sup.a).sub.2, andZ.sub.ii is --O or (.dbd.O).sub.2 ;whereinR.sub.1, R.sub.2, R.sub.3, and R.sub.4 are as defined in the specification.Type: GrantFiled: May 3, 1996Date of Patent: December 15, 1998Assignee: Medivir ABInventors: Peter Thomas Lind, Rolf Noreen, John Michael Morin, Robert John Ternansky
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Patent number: 5714503Abstract: Treatment of AIDS, inhibition of the replication of HIV and related viruses thereof, and formulations using thiourea derivative compounds or salts thereof is disclosed. Also disclosed are novel thiourea derivative compounds.Type: GrantFiled: May 31, 1995Date of Patent: February 3, 1998Assignee: Medivir ABInventors: John M. Morin, Jr., Robert J. Ternansky, Rolf Noreen, Peter Tomas Lind
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Patent number: 5658907Abstract: Treatment of AIDS, inhibition of the replication of HIV and related viruses thereof, and formulations using thiourea derivative compounds or salts thereof is disclosed. Also disclosed are novel thiourea derivative compounds.Type: GrantFiled: May 31, 1995Date of Patent: August 19, 1997Assignee: Medivir A/BInventors: John M. Morin, Jr., Robert J. Ternansky, Rolf Noreen, Peter Tomas Lind
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Patent number: 5656658Abstract: A method is disclosed for the treatment of anxiety by the administration of 3-amino-5-carbamoyl-chromans and 8-fluoro-3-amino-5-carbamoylchromans or enantiomers or salts thereof.Type: GrantFiled: May 30, 1995Date of Patent: August 12, 1997Assignee: Astra AktiebolagInventors: Eva Maria Hammarberg, Lars George Johansson, Lars-Gunnar Larsson, Rolf Noreen, Lucy Anna Renyi, Svante Bertil Ross, Daniel Dungan Sohn, Bjorn Eric Svensson, Seth-Olov Thorberg
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Patent number: 5656657Abstract: 3-amino-5-carbonylchromans, as well as enantiomers and salts thereof are disclosed. Pharmaceutical compositions containing the compounds as active ingredients are also disclosed. The compounds are useful in the treatment of 5-hydroxytryptamine-mediated disorders of the central nervous system.Type: GrantFiled: May 30, 1995Date of Patent: August 12, 1997Assignee: Astra AktiebolagInventors: Eva Maria Hammarberg, Lars George Johansson, Lars-Gunnar Larsson, Rolf Noreen, Lucy Anna Renyi, Svante Bertil Ross, Daniel Dungan Sohn, Bjorn Eric Svensson, Seth-Olov Thorberg
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Patent number: 5646309Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are employed as intermediates in the synthesis of aminochroman compounds useful in the treatment of CNS disorders.Type: GrantFiled: May 30, 1995Date of Patent: July 8, 1997Assignee: Astra AktiebolagInventors: Eva Maria Hammarberg, Lars George Johansson, Lars-Gunnar Larsson, Rolf Noreen, Lucy Anna Renyi, Svante Bertil Ross, Daniel Dungan Sohn, Bjorn Eric Svensson, Seth-Olov Thorberg
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Patent number: 5641807Abstract: A method is disclosed for the treatment of depression by the administration of 3-amino-5-carbamoylchromans and 8-fluoro-3-amino-5-carbamoylchromans or enantiomers or salts thereof.Type: GrantFiled: May 30, 1995Date of Patent: June 24, 1997Assignee: Astra AktiebolagInventors: Eva Maria Hammarberg, Lars George Johansson, Lars-Gunnar Larsson, Rolf Noreen, Lucy Anna Renyi, Svante Bertil Ross, Daniel Dungan Sohn, Bjorn Eric Svensson, Seth-Olov Thorberg
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Patent number: 5639772Abstract: 3-amino-5-aryl- and 5-heteroarylchromans, as well as enantiomers and salts thereof are disclosed. Pharmaceutical compositions containing the compounds as active ingredients are also disclosed. The compounds are useful in the treatment of 5-hydroxytryptamine-mediated disorders of the central nervous system.Type: GrantFiled: May 30, 1995Date of Patent: June 17, 1997Assignee: Astra AktiebolagInventors: Eva Maria Hammarberg, Lars George Johansson, Lars-Gunnar Larsson, Rolf Noreen, Lucy Anna Renyi, Svante Bertil Ross, Daniel Dungan Sohn, Bjorn Eric Svensson, Seth-Olov Thorberg
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Patent number: 5639784Abstract: A method is disclosed for the treatment of migraine by the administration of 3-amino-5-carbamoyl-chromans and 8-fluoro-3-amino-5-carbamoylchromans or enantiomers or salts thereof.Type: GrantFiled: May 30, 1995Date of Patent: June 17, 1997Assignee: Astra AktiebolagInventors: Eva Maria Hammarberg, Lars George Johansson, Lars-Gunnar Larsson, Rolf Noreen, Lucy Anna Renyi, Svante Bertil Ross, Daniel Dungan Sohn, Bjorn Eric Svensson, Seth-Olov Thorberg
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Patent number: 5593993Abstract: Treatment of AIDS, inhibition of the replication of HIV and related viruses thereof, and formulations using thiourea derivative compounds or salts thereof is disclosed. Also disclosed are novel thiourea derivative compounds.Type: GrantFiled: February 28, 1995Date of Patent: January 14, 1997Assignee: Medivir ABInventors: John M. Morin, Jr., Robert J. Ternansky, Rolf Noreen, Tomas Lind
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Patent number: 5576429Abstract: The present invention is directed to compounds of formula (I), ##STR1## wherein R.sup.1 is OH, NH.sub.2 ; R.sup.2 is a heteroaromatic or aromatic substituent; R.sup.3 is H, OH, F, OCH.sub.3 ; R.sup.4 is H, F, OH or an ether or ester residue thereof, OCH.sub.3, CN, C.dbd.CH, N.sub.3 ; R.sup.5 is OH or an ether or ester residue thereof including mono, di- and triphosphate esters (.alpha.), wherein n is 0 or 1 and M is hydrogen or a pharmaceutically acceptable counterion such as sodium, potassium, ammonium or alkylammonium; and pharmaceutically acceptable salts thereof; and pharmaceutical compositions comprising said compounds can be used for therapeutic treatment of virus infections.Type: GrantFiled: February 28, 1995Date of Patent: November 19, 1996Assignee: Medivir ABInventors: Karl N. G. Johansson, Hans C. G. Malmberg, Rolf Noreen, S. Christer Sahlberg, Daniel D. Sohn, Sal o Gronowitz