Patents by Inventor Rolf Paul

Rolf Paul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MDR reversal agents
    Patent number: 5639887
    Abstract: Compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are herein described, A is a straight or branched (C.sub.2 -C.sub.12)alkyl or a phenyl moiety and B is a moiety of the formula: ##STR2## The compounds are effective in potentiating the activity of chemotherapeutic anti-cancer agents by increasing the sensitivity of multi-drug resistant cells to such chemotherapeutic agents.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: June 17, 1997
    Assignee: American Cyanamid Company
    Inventors: Dennis Powell, Rolf Paul, William A. Hallett, Dan M. Berger, Minu D. Dutia
  • MDR reversal agents
    Patent number: 5561141
    Abstract: Compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are herein described, A is a straight or branched (C.sub.2 -C.sub.12)alkyl or a phenyl moiety and B is a moiety of the formula: ##STR2## The compounds are effective in potentiating the activity of chemotherapeutic anti-cancer agents by increasing the sensitivity of multi-drug resistant cells to such chemotherapeutic agents.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: October 1, 1996
    Assignee: American Cyanamid Company
    Inventors: Dennis Powell, Rolf Paul, William A. Hallett, Dan M. Berger, Minu D. Dutia
  • MDR reversal agents
    Patent number: 5550149
    Abstract: Compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are herein described, A is a straight or branched (C.sub.2 -C.sub.12)alkyl or a phenyl moiety and B is a moiety of the formula: ##STR2## The compounds are effective in potentiating the activity of chemotherapeutic anti-cancer agents by increasing the sensitivity of multi-drug resistant cells to such chemotherapeutic agents.
    Type: Grant
    Filed: October 25, 1994
    Date of Patent: August 27, 1996
    Assignee: American Cyanamid Company
    Inventors: Dennis Powell, Rolf Paul, William A. Hallett, Dan M. Berger, Minu D. Dutia
  • MDR reversal agents
    Patent number: 5387685
    Abstract: Compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are herein described, A is a straight or branched (C.sub.2 -C.sub.12)alkyl or a phenyl moiety and B is a moiety of the formula: ##STR2## The compounds are effective in potentiating the activity of chemotherapeutic anti-cancer agents by increasing the sensitivity of multi-drug resistant cells to such chemotherapeutic agents.
    Type: Grant
    Filed: July 16, 1993
    Date of Patent: February 7, 1995
    Inventors: Dennis Powell, Rolf Paul, William A. Hallett, Dan M. Berger, Minu D. Dutia
  • N-[3-[2-(1H-imidazol-1-yl)ethoxy]phenyl]-4-(2-thienyl)-2-pyrimidinamine and pharmacologically acceptable salts
    Patent number: 5162328
    Abstract: N-[3-[2-(1H-Imidazol-1-yl)ethoxy]phenyl]-4-(2-thienyl)-2-pyrimidinamine and pharmacologicaly acceptable salts, useful as antiasthma agents and treatment of allergic diseases and exhibiting improved bioavailability properties.
    Type: Grant
    Filed: December 31, 1991
    Date of Patent: November 10, 1992
    Assignee: American Cyanamid Company
    Inventors: Rolf Paul, Robert G. Kelly, Lawrence W. Torley
  • 5-substituted[1,2,4]triazolo[1,5-c]pyrimidin-2-amines
    Patent number: 4579848
    Abstract: This invention is concerned with 5-substituted[1,2,4]triazolo[1,5-c]pyrimidin-2-amines selected from those of Formula I, which are active as antiasthma agents.
    Type: Grant
    Filed: September 24, 1984
    Date of Patent: April 1, 1986
    Assignee: American Cyanamid Company
    Inventors: Rolf Paul, Robert A. Hardy, Jr., John A. Brockman
  • Substituted-6-n-propyl-8-methylimidazo[1,5-d]-as-triazin-4-(3H)-ones
    Patent number: 4447603
    Abstract: This disclosure describes new compounds and compositions of matter useful as anti-asthmatic agents and the method of meliorating asthma in mammals therewith, the novel active ingredients of said compositions of matter being certain 1-substituted-6-n-propyl-8-methylimidazo [1,5-d]-as-triazin-4(3H)-ones and/or the pharmacologically acceptable acid-addition salts thereof.
    Type: Grant
    Filed: February 4, 1981
    Date of Patent: May 8, 1984
    Assignee: American Cyanamid Company
    Inventor: Rolf Paul
  • Substituted 3-(4-imidazolylmethylene)carbazic and thiocarbazic acid esters
    Patent number: 4124766
    Abstract: There are provided substituted 3-(4-imidazolyl-methylene)carbazic acid esters and 3-(4-imidazolylmethylene)dithiocarbazic acid esters useful as intermediates for the preparation of compounds which inhibit the enzyme cyclic-AMP phosphodiesterase.
    Type: Grant
    Filed: November 7, 1977
    Date of Patent: November 7, 1978
    Assignee: American Cyanamid Company
    Inventors: Rolf Paul, Judith Menschik
  • Imidazo-[1,5-d]-as-triazin-1(2H)-ones and method of ameliorating asthma
    Patent number: 4115572
    Abstract: There are provided substituted imidazo[1,5-d]-as-triazin-1(2H)-ones useful as anti-asthmatic agents.
    Type: Grant
    Filed: October 18, 1977
    Date of Patent: September 19, 1978
    Assignee: American Cyanamid Company
    Inventors: Rolf Paul, Judith Menschik
  • Imidazo[1,5-d]-as-triazines
    Patent number: 4107308
    Abstract: There are provided novel substituted imidazo-[1,5-d]-as-triazines useful as hypotensive agents as well as exhibiting herbicidal activity.
    Type: Grant
    Filed: October 18, 1977
    Date of Patent: August 15, 1978
    Assignee: American Cyanamid Company
    Inventors: Rolf Paul, Judith Menschik
  • Substituted imidazo[1,2-d]-as-triazines
    Patent number: 4107309
    Abstract: This disclosure describes novel 5-substituted imidazo[1,2-d]-as-triazines useful as anti-asthmatic agents and as inhibitors of the enzyme cyclic-AMP phosphodiesterase.
    Type: Grant
    Filed: May 23, 1977
    Date of Patent: August 15, 1978
    Assignee: American Cyanamid Company
    Inventors: Rolf Paul, Judith Menschik
  • Imidazo [1,5-d]-as-triazine-4(3H)-ones and thiones
    Patent number: 4107307
    Abstract: There is provided substituted imidazo[1,5-d]-as-triazine-4(3H)-ones and substituted imidazo[1,5-d]-as-triazin-4(3H)-thiones useful as inhibitors of the enzyme cyclic-AMP phosphodiesterase and as broad spectrum herbicides.
    Type: Grant
    Filed: October 18, 1977
    Date of Patent: August 15, 1978
    Assignee: American Cyanamid Company
    Inventors: Rolf Paul, Judith Menschik
  • Substituted imidazo [1,2-d]-as-triazines
    Patent number: 4096257
    Abstract: This disclosure describes 5-n-propyl-imidazo[1,2-d]-as-triazin-8(7H)-one and 5-phenyl-imidazo[1,2-d]-as-triazin-8(7H)-one which are useful as anti-asthmatic agents and as inhibitors of the enzyme cyclic-AMP phosphodiesterase.
    Type: Grant
    Filed: May 23, 1977
    Date of Patent: June 20, 1978
    Assignee: American Cyanamid Company
    Inventors: Judith Menschik, Rolf Paul
  • Imidazo[1,5-d]-as-triazine-4(3H)-ones and thiones
    Patent number: RE30511
    Abstract: There is provided substituted imidazo[1,5-d]-as-triazine-4(3H)-ones and substituted imidazo[1,5-d]-as-triazin-4(3H)-thiones useful as inhibitors of the enzyme cyclic-AMP phosphodiesterase and as broad spectrum herbicides.
    Type: Grant
    Filed: August 8, 1979
    Date of Patent: February 10, 1981
    Assignee: American Cyanamid Company
    Inventors: Rolf Paul, Judith Menschik