Patents by Inventor Rolfe C. Anderson
Rolfe C. Anderson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100168561Abstract: Intraoperative devices are described that assist the surgeon in identifying the location and characteristics of tissues and structures. Devices are also described that have the added capability of marking the location of the identified tissues and structures. This invention also includes devices that can selectively ablate adjacent tissues while avoiding damage and trauma to the identified tissues and structures by combining ablation with sensing, where sensing of either tissue properties, markings made by another device or surgeon, or a reference probe can be used. Devices are also described that protect tissue in the proximity of reference markings or probes by closed loop inhibition of the ablation process. The devices, systems, methods and kits described are adapted and configured to facilitate locating a target structure or target tissue within a body of a mammal, including nerves, peripheral nerves, blood vessels, and tubes such as the ureter.Type: ApplicationFiled: December 18, 2007Publication date: July 1, 2010Applicant: TRILLIUM PRECISION SURGICAL, INC.Inventor: Rolfe C. Anderson
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Patent number: 6864050Abstract: The amplification of nucleic acids in a single phase can reliably provide products at relatively low cost and labor. A single-phase amplification can also increase the amount of nucleic acids while preserving the relative abundance of the individual nucleic acid species, or portions thereof. A single-phase amplified nucleic acid preparation may be analyzed in a gene expression monitoring system, preferably involving a nucleic acid probe array.Type: GrantFiled: August 16, 1999Date of Patent: March 8, 2005Assignee: Affymetrix, Inc.Inventors: Xing Su, Rolfe C. Anderson
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Patent number: 6830936Abstract: The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.Type: GrantFiled: December 31, 2000Date of Patent: December 14, 2004Assignee: Affymetrix Inc.Inventors: Rolfe C. Anderson, Robert J. Lipshutz, Richard P. Rava, Stephen P. A. Fodor
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Publication number: 20020172975Abstract: A method of detecting locations on a nucleic acid probe array at which hybridization occurs between targets in a fluid sample and nucleic acid probes disposed on a surface of the nucleic acid probe array, comprising: measuring the temperature at a plurality of locations on the surface of the nucleic acid probe array; applying an oscillating level of energy to the surface of the nucleic acid probe array, thereby causing the temperature at the surface of the nucleic acid probe array to oscillate; and detecting a decreased range of temperature oscillation at at least one of the plurality of locations on the nucleic acid probe array, thereby indicating an increased heat capacity caused by latent heat of hybridization between at least one target in the fluid sample and at least one nucleic acid probe disposed on a surface of the nucleic acid probe array.Type: ApplicationFiled: July 8, 2002Publication date: November 21, 2002Applicant: AFFYMETRIX, INC.Inventor: Rolfe C. Anderson
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Patent number: 6403317Abstract: A method of detecting locations on a nucleic acid probe array at which hybridization occurs between targets in a fluid sample and nucleic acid probes disposed on a surface of the nucleic acid probe array, comprising: measuring the temperature at a plurality of locations on the surface of the nucleic acid probe array; applying an oscillating level of energy to the surface of the nucleic acid probe array, thereby causing the temperature at the surface of the nucleic acid probe array to oscillate; and detecting a decreased range of temperature oscillation at least one of the plurality of locations on the nucleic acid probe array, thereby indicating an increased heat capacity caused by latent heat of hybridization between at least one target in the fluid sample and at least one nucleic acid probe disposed on a surface of the nucleic acid probe array.Type: GrantFiled: March 24, 2000Date of Patent: June 11, 2002Assignee: Affymetrix, Inc.Inventor: Rolfe C. Anderson
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Publication number: 20020022261Abstract: The present invention provides a miniaturized integrated nucleic acid diagnostic device and system.Type: ApplicationFiled: December 31, 2000Publication date: February 21, 2002Inventors: Rolfe C. Anderson, Robert J. Lipshutz, Richard P. Rava, Stephen P. A. Fodor
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Publication number: 20010053541Abstract: The amplification of nucleic acids in a single phase can reliably provide products at relatively low cost and labor. A single-phase amplification can also increase the amount of nucleic acids while preserving the relative abundance of the individual nucleic acid species, or portions thereof. A single-phase amplified nucleic acid preparation may be analyzed in a gene expression monitoring system, preferably involving a nucleic acid probe array.Type: ApplicationFiled: August 16, 1999Publication date: December 20, 2001Inventors: XING SU, ROLFE C. ANDERSON
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Patent number: 6326211Abstract: The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.Type: GrantFiled: March 10, 2000Date of Patent: December 4, 2001Assignee: Affymetrix, Inc.Inventors: Rolfe C. Anderson, Robert J. Lipshutz, Richard P. Rava, Stephen P. A. Fodor
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Publication number: 20010036672Abstract: The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.Type: ApplicationFiled: December 31, 2000Publication date: November 1, 2001Inventors: Rolfe C. Anderson, Robert J. Lipshutz, Richard P. Rava, Stephen P. A. Fodor
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Patent number: 6197595Abstract: The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.Type: GrantFiled: April 19, 1999Date of Patent: March 6, 2001Assignee: Affymetrix, Inc.Inventors: Rolfe C. Anderson, Robert J. Lipshutz, Richard P. Rava, Stephen P. A. Fodor
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Patent number: 6168948Abstract: The present invention provides a miniaturized integrated nucleic acid diagnostic device and system which includes a nucleic acid extraction zone including nucleic acid binding sites.Type: GrantFiled: January 12, 1998Date of Patent: January 2, 2001Assignee: Affymetrix, Inc.Inventors: Rolfe C. Anderson, Robert J. Lipshutz, Richard P. Rava, Stephen P. A. Fodor
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Patent number: 6043080Abstract: The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.Type: GrantFiled: December 11, 1998Date of Patent: March 28, 2000Assignee: Affymetrix, Inc.Inventors: Robert J. Lipshutz, Richard P. Rava, Rolfe C. Anderson, Stephen P. A. Fodor
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Patent number: 5922591Abstract: The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.Type: GrantFiled: June 27, 1996Date of Patent: July 13, 1999Assignee: Affymetrix, Inc.Inventors: Rolfe C. Anderson, Robert J. Lipshutz, Richard P. Rava, Stephen P. A. Fodor
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Patent number: 5856174Abstract: The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.Type: GrantFiled: January 19, 1996Date of Patent: January 5, 1999Assignee: Affymetrix, Inc.Inventors: Robert J. Lipshutz, Richard P. Rava, Rolfe C. Anderson, Stephen P. A. Fodor