Patents by Inventor Roli K. Hirata

Roli K. Hirata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Beta-2 microglobulin-deficient cells
    Patent number: 11813318
    Abstract: The invention provides isolated primate cells preferably human cells that comprise a genetically engineered disruption in a beta-2 microglobulin (B2M) gene, which results in deficiency in MHC class I expression and function. Also provided are the method of using the cells for transplantation and treating a disease condition.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: November 14, 2023
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: David W. Russell, Roli K. Hirata
  • BETA-2 MICROGLOBULIN-DEFICIENT CELLS
    Publication number: 20190381154
    Abstract: The invention provides isolated primate cells preferably human cells that comprise a genetically engineered disruption in a beta-2 microglobulin (B2M) gene, which results in deficiency in MHC class I expression and function. Also provided are the method of using the cells for transplantation and treating a disease condition.
    Type: Application
    Filed: July 10, 2019
    Publication date: December 19, 2019
    Inventors: David W. Russell, Roli K. Hirata
  • HLA Class II Deficient Cells, HLA Class I Deficient Cells Capable of Expressing HLA Class II Proteins, and Uses Thereof
    Publication number: 20190365876
    Abstract: The invention provides isolated primate cells preferably human cells that comprise a genetically engineered disruption in a human leukocyte antigen (HLA) class II-related gene, which results in deficiency in MHC class II expression and function. This invention also provides isolated cells further comprising a genetically engineered disruption in a beta-2 microglobulin (B2M) gene, which results in HLA class I/class II deficiency. Also provided are the method of using the cells for transplantation and treating a disease condition.
    Type: Application
    Filed: June 14, 2019
    Publication date: December 5, 2019
    Inventors: David W. Russell, Roli K. Hirata
  • Targeted gene modification by parvoviral vectors
    Patent number: 8846387
    Abstract: This invention provides methods for obtaining targeted gene modification in vertebrate cells using parvoviral vectors, including adeno-associated virus (AAV). The parvoviral vectors used in the methods of the invention are capable of targeting a specific genetic modification to a preselected target locus in a cellular genome by homologous pairing.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: September 30, 2014
    Assignee: The University of Washington
    Inventors: David W. Russell, Roli K. Hirata
  • HLA homozygous cells
    Patent number: 8586358
    Abstract: The present invention provides methods of generating a mammalian cell that is homozygous at a locus of interest, as well as cells made by the method. The present invention further provides methods of using the cells.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: November 19, 2013
    Assignee: University of Washington
    Inventors: David W. Russell, Roli K. Hirata
  • HLA HOMOZYGOUS CELLS AND METHODS OF USE THEREOF
    Publication number: 20120093790
    Abstract: The present invention provides methods of generating a mammalian cell that is homozygous at a locus of interest, as well as cells made by the method. The present invention further provides methods of using the cells.
    Type: Application
    Filed: December 21, 2011
    Publication date: April 19, 2012
    Applicant: University of Washington
    Inventors: David W. RUSSELL, Roli K. HIRATA
  • TARGETED GENE MODIFICATION BY PARVOVIRAL VECTORS
    Publication number: 20120070890
    Abstract: This invention provides methods for obtaining targeted gene modification in vertebrate cells using parvoviral vectors, including adeno-associated virus (AAV). The parvoviral vectors used in the methods of the invention are capable of targeting a specific genetic modification to a preselected target locus in a cellular genome by homologous pairing.
    Type: Application
    Filed: May 24, 2011
    Publication date: March 22, 2012
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: David W. Russell, Roli K. Hirata
  • Parvoviral production of HLA homozygous cells
    Patent number: 8105831
    Abstract: The present invention provides methods of generating a mammalian cell that is homozygous at a locus of interest, as well as cells made by the method. The present invention further provides methods of using the cells.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: January 31, 2012
    Assignee: University of Washington
    Inventors: David W. Russell, Roli K. Hirata
  • Targeted gene modification by parvoviral vectors
    Patent number: 7972856
    Abstract: This invention provides methods for obtaining targeted gene modification in vertebrate cells using parvoviral vectors, including adeno-associated virus (AAV). The parvoviral vectors used in the methods of the invention are capable of targeting a specific genetic modification to a preselected target locus in a cellular genome by homologous pairing.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: July 5, 2011
    Assignee: The University of Washington
    Inventors: David W. Russell, Roli K. Hirata
  • Targeted gene modification by parvoviral vectors
    Publication number: 20110097804
    Abstract: This invention provides methods for obtaining targeted gene modification in vertebrate cells using parvoviral vectors, including adeno-associated virus (AAV). The parvoviral vectors used in the methods of the invention are capable of targeting a specific genetic modification to a preselected target locus in a cellular genome by homologous pairing.
    Type: Application
    Filed: April 24, 2003
    Publication date: April 28, 2011
    Inventors: David W. Russell, Roli K. Hirata
  • HLA HOMOZYGOUS CELLS AND METHODS OF USE THEREOF
    Publication number: 20080219956
    Abstract: The present invention provides methods of generating a mammalian cell that is homozygous at a locus of interest, as well as cells made by the method. The present invention further provides methods of using the cells.
    Type: Application
    Filed: March 7, 2008
    Publication date: September 11, 2008
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: DAVID W. RUSSELL, ROLI K. HIRATA