Abstract: System for the optical examination of human nails that has a camera and a power source or a smartphone provided with a connection to these, a converter connected to the smartphone, which converter contains a housing and a measuring probe, the housing contains a microcontroller, the measuring probe contains at least one macro lens and at least one polarising filter, at least two light sources and a polarising filter film in front of some of the light sources arranged in such a way that the axes of polarisation of the polarising filter films and of the polarising filter are rotated by 90 degrees as compared to each other, where due to the various light sources the system is adapted to use various illumination modes and the smartphone is connected to a neural network. Also, a method for the examination of nails for diagnostic purposes with such devices.

Abstract: An affinity ligand is reactive to the GARP protein may be capable of binding to an extracellular domain of GARP protein expressed on regulatory T (Treg) cells. The affinity ligand may be an antibody and may be used to identify Treg cells. A method comprises providing a blood sample from a subject and determining the amount of Treg cells in that sample. A composition containing Treg cells may be administered to an individual to suppress effector T cell activity in the individual. A composition containing an affinity ligand capable of binding to a GARP domain may be administered to an individual to suppress Treg cell activity and increase effector T cell activity in the individual. A kit for detecting Treg cells may include an affinity ligand reactive with mammalian GARP protein.

Abstract: An affinity ligand is reactive to the GARP protein may be capable of binding to an extracellular domain of GARP protein expressed on regulatory T (Treg) cells. The affinity ligand may be an antibody and may be used to identify Treg cells. A method comprises providing a blood sample from a subject and determining the amount of Treg cells in that sample. A composition containing Treg cells may be administered to an individual to suppress effector T cell activity in the individual. A composition containing an affinity ligand capable of binding to a GARP domain may be administered to an individual to suppress Treg cell activity and increase effector T cell activity in the individual. A kit for detecting Treg cells may include an affinity ligand reactive with mammalian GARP protein.