Patents by Inventor Romain Zufferey

Romain Zufferey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for identifying a CIS-acting RNA export element
    Patent number: 6312912
    Abstract: A cis-acting posttranscriptional regulatory element (PRE) useful for efficient RNA export of RNA is provided. The element, termed WPRE, is originally derived from woodchuck hepatitis virus. The invention also provides a method for enhancing the expression of transgenes by insertion of the WPRE nucleic acid sequences in operably linkage with the transgene.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: November 6, 2001
    Assignee: Salk Institute
    Inventors: Thomas J. Hope, Romain Zufferey, Didier Trono, John Edward Donello
  • RNA export element and methods of use
    Patent number: 6287814
    Abstract: A cis-acting posttranscriptional regulatory element (PRE) useful for efficient RNA export of RNA is provided. The element, termed WPRE, is originally derived from woodchuck hepatitis virus. The invention also provides a method for enhancing the expression of transgenes by insertion of the WPRE nucleic acid sequences in operably linkage with the transgene.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: September 11, 2001
    Assignee: Salk Institute
    Inventors: Thomas J. Hope, Romain Zufferey, Didier Trono, John Edward Donello
  • RNA export element and methods of use
    Patent number: 6284469
    Abstract: A cis-acting posttranscriptional regulatory element (PRE) useful for efficient RNA export of RNA is provided. The element, termed WPRE, is originally derived from woodchuck hepatitis virus. The invention also provides a method for enhancing the expression of transgenes by insertion of the WPRE nucleic acid sequences in operably linkage with the transgene.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: September 4, 2001
    Assignee: The Salk Institute
    Inventors: Thomas J. Hope, Romain Zufferey, Didier Trono, John Edward Donello
  • RNA export element
    Patent number: 6136597
    Abstract: A cis-acting posttranscriptional regulatory element (PRE) useful for efficient RNA export of RNA is provided. The element termed WPRE, is originally derived from woodchuck hepatitis virus. The invention also provides a method for enhancing the expression of transgenes by insertion of the WPRE nucleic acid sequences in operably linkage with the transgene.
    Type: Grant
    Filed: September 18, 1997
    Date of Patent: October 24, 2000
    Assignee: The Salk Institute for Biological Studies
    Inventors: Thomas J. Hope, Romain Zufferey, Didier Trono, John Edward Donello