Abstract: A slurry chamber is fastened to and held in coaxial alignment with a chromatography column by a V-band. One end of the column has an end cap and frit. A slurry of fluid and chromatographic media is placed in the column and chamber. A piston is forced through the chamber and into the column by a hydraulic ram to expel the fluid and form a media bed in the column. The slurry chamber is removed, and a split end cap is fastened to the column. A threaded recess in the split end cap receives a split, threaded collet. The collet is tightened until it pushes against the piston with the same force as the ram, at which point the ram is released and the column removed for use.

Abstract: A slurry chamber is fastened to and held in coaxial alignment with a chromatography column by a V-band. One end of the column has an end cap and frit. A slurry of fluid and chromatographic media is placed in the column and chamber. A piston is forced through the chamber and into the column by a hydraulic ram to expel the fluid and form a media bed in the column. The slurry chamber is removed, and a split end cap is fastened to the column. A threaded recess in the split end cap receives a split, threaded collet. The collet is tightened until it pushes against the piston with the same force as the ram, at which point the ram is released and the column removed for use.

Abstract: A slurry chamber is fastened to and held in coaxial alignment with a chromatography column by a V-band. One end of the column has an end cap and frit. A slurry of fluid and chromatographic media is placed in the column and chamber. A piston is forced through the chamber and into the column by a hydraulic ram to expel the fluid and form a media bed in the column. The slurry chamber is removed, and a split end cap is fastened to the column. A threaded recess in the split end cap receives a split, threaded collet. The collet is tightened until it pushes against the piston with the same force as the ram, at which point the ram is released and the column removed for use.

Abstract: A slurry chamber is fastened to and held in coaxial alignment with a chromatography column by a V-band. One end of the column has an end cap and fit. A slurry of fluid and chromatographic media is placed in the column and chamber. A piston is forced through the chamber and into the column by a hydraulic ram to expel the fluid and form a media bed in the column. The slurry chamber is removed, and a split end cap is fastened to the column. A threaded recess in the split end cap receives a split, threaded collet. The collet is tightened until it pushes against the piston with the same force as the ram, at which point the ram is released and the column removed for use.

Abstract: A slurry chamber is fastened to and held in coaxial alignment with a chromatography column by a V-band. One end of the column has an end cap and frit. A slurry of fluid and chromatographic media is placed in the column and chamber. A piston is forced through the chamber and into the column by a hydraulic ram to expel the fluid and form a media bed in the column. The slurry chamber is removed, and a split end cap is fastened to the column. A threaded recess in the split end cap receives a split, threaded collet. The collet is tightened until it pushes against the piston with the same force as the ram, at which point the ram is released and the column removed for use.

Abstract: A multiple-channel spectrometer assembly for analyzing a plurality of sample flows. The assembly includes a plurality of spectrometer channels, each fluidly connectable to a respective one of the sample flows. Each channel has a sample inlet and a sample outlet connectable to a respective one of the sample flows. Each channel has a chassis and a light source mounted to the chassis. A spectrometer module is adjacent to each chassis and is optically coupled a light outlet portion of the light source. The spectrometer module has an optical inlet axially coupled to the light outlet portion to receive light from the light source. A high-pressure flow cell assembly is positioned adjacent to the chassis between the light source and the spectrometer module to emulate a fiber optic cable therebetween. The flow cell assembly has a flow passageway in fluid communication with the sample inlet and sample outlet.

Abstract: A multiple-channel spectrometer assembly for analyzing a plurality of sample flows. The assembly includes a plurality of spectrometer channels, each fluidly connectable to a respective one of the sample flows. Each channel has a sample inlet and a sample outlet connectable to a respective one of the sample flows. Each channel has a chassis and a light source mounted to the chassis. A spectrometer module is adjacent to each chassis and is optically coupled a light outlet portion of the light source. The spectrometer module has an optical inlet axially coupled to the light outlet portion to receive light from the light source. A high-pressure flow cell assembly is positioned adjacent to the chassis between the light source and the spectrometer module to emulate a fiber optic cable therebetween. The flow cell assembly has a flow passageway in fluid communication with the sample inlet and sample outlet.

Abstract: A system for producing a library of oligomer comprising at least two monomers in a positionally determined array comprise a plurality of synthesis supports, a first plurality of support carriers wherein each carrier has a uniform array of distinct support holding positions for the synthesis supports; means for contacting each array of synthesis supports with a different monomer to provide a first chemical transformation of the synthesis supports; a second plurality of support carriers wherein each carrier has a uniform array of distinct support holding positions for receiving the chemically transformed synthesis supports contained in the first plurality of support carriers; transfer apparatus for transferring a selected row or column of synthesis supports from each of the first plurality of carriers to each of the second plurality of carriers to enable the supports in the second to undergo at least a second chemical transformation; and whereby each support position in each carrier identifies the chemical comp

Abstract: A system for producing a library of oligomer comprising at least two monomers in a positionally determined array comprise a plurality of synthesis supports, a first plurality of support carriers wherein each carrier has a uniform array of distinct support holding positions for the synthesis supports; means for contacting each array of synthesis supports with a different monomer to provide a first chemical transformation of the synthesis supports; a second plurality of support carriers wherein each carrier has a uniform array of distinct support holding positions for receiving the chemically transformed synthesis supports contained in the first plurality of support carriers; transfer apparatus for transferring a selected row or column of synthesis supports from each of the first plurality of carriers to each of the second plurality of carriers to enable the supports in the second to undergo at least a second chemical transformation; and whereby each support position in each carrier identifies the chemical comp

Abstract: A high throughput liquid chromotagraphy column assembly for separating a large sample with a selected mass weight and fluid volume. The assembly includes a loading column with a loading chamber with a first inner diameter and a first length. The loading chamber contains a removable cartridge containing a bed packing material on to which sample is loaded and spatially distributed. The cartridge's volume is sufficient to fully load the sample therein but the length of the loading chamber is insufficient to achieve the selected chromatographic separation. A separation column is in fluid communication with the loading column. The separation column has a separation chamber with a diameter smaller than the loading cartridge's inner diameter and a length greater than the cartridge's length. In one embodiment, the cartridge has an inner diameter two or more times greater than the separation chamber's diameter, and the cartridge has a length one-half or less than the length of the separation chamber.

Abstract: A docking station includes remotely actuated locking mechanisms for secure registration of reaction blocks, and provides for introduction of gases, liquids, and vacuum to the reaction blocks.

Abstract: Methods and apparatus for the generation of chemical libraries are described. The preferred embodiments include a reaction block which uses replaceable reaction chambers supported in the block. Each reaction block is fitted with four sets of 12 reaction chambers, and has fittings that facilitate robotic manipulation. The reaction chambers are preferably fitted with a frit. An s-shaped trap tube snaps into a fitting on the bottom of each reaction chamber. The trap tube runs into a drain tube. The reaction block is fitted with gas (preferably N.sub.2) lines and a septum seal such that gas pressurization empties the reaction chambers into the drain tubes. The drain tubes are arranged so as to mate directly with a standard 96 well microtiter plate for the collection of material. A docking station provides for secure registration of the reaction blocks, and provides for introduction of gases and liquids into the reaction blocks.

Abstract: Methods and apparatus for the generation of chemical libraries are described. The preferred embodiments include a reaction block which uses replaceable reaction chambers supported in the block. Each reaction block is fitted with four sets of 12 reaction chambers, and has fittings that facilitate robotic manipulation. The reaction chambers are preferably fitted with a frit. An s-shaped trap tube snaps into a fitting on the bottom of each reaction chamber. The trap tube runs into a drain tube. The reaction block is fitted with gas (preferably N.sub.2) lines and a septum seal such that gas pressurization empties the reaction chambers into the drain tubes. The drain tubes are arranged so as to mate directly with a standard 96 well microtiter plate for the collection of material. A docking station provides for secure registration of the reaction blocks, and provides for introduction of gases and liquids into the reaction blocks.

Abstract: An apparatus for protecting an auto from hijacking, comprises a nozzle for mounting in a position adjacent a driver's door for directing a spray of a disabling substance into an area at about face level at the driver's door, a source of pressurized disabling fluid, a conduit for connecting the source of fluid to the nozzle for delivering a selected quantity of the fluid to the nozzle, and a remote control switch operative from the driver's seat of the auto for initiating the dispensing of a quantity of the fluid via the nozzle.

Abstract: A liquid electrophotographic development system has a plurality of removable cartridges mounted on a rotatable support for selective engagement with an electrophotographic member to be developed. Each cartridge has a liquid developer reservoir and a flexible toner concentrate container from which concentrate is supplied to the developer in the reservoir as needed. A fluted roll pumps developer in a uniform manner from the reservoir to the electrophotographic member. After depletion of the toner concentrate and developer, any developer remaining in the cartridge can be pumped into the flexible container to prevent spillage on disposal of the cartridge. The cartridge housing has only one opening and minimum-size passages between the reservoir and the opening to inhibit evaporation of developer liquid.

Abstract: Positive displacement pumps, each having multiple pistons reciprocated by a swash plate, are connected to corresponding liquid reservoirs and are individually actuated to dispense a selected liquid type and pour size volume through a hand held gun. A digital control circuit receives feedback from an emitter, detector, chopper wheel combination associated with each pump to monitor the amount of liquid dispensed. The control circuit also monitors the actuation of switches on each dispensing gun and causes the desired pour size volume of the selected liquid to be dispensed. Pour size volume and pricing information may be programmed through a keyboard coupled to the control circuit and accounting information may be displayed or printed on command.