Patents by Inventor Roman EFFENBERG

Roman EFFENBERG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aminooxylipids for the construction of self-assembling liposomal systems enabling their subsequent modification by biologically functional molecules
    Patent number: 11492327
    Abstract: New aminooxylipids of general formula I, wherein n1=5-30 and X is polymethylene linker of the general formula II where n2=2-10, or X is polyethylene glycol linker of the general formula III, wherein n3=1-14 are provided. A method of preparation of the aminooxylipids of general formula I characterized in that the acylation of N-tert-butoxycarbonyl-polymethylenediamine {(CH3)3C—O—(C?O)—HN—(CH2)n—NH2, n=2-13}, or N-tert-butoxycarbonyl-polyethyleglycoldiamine {(CH3)3C—O—(C?O)—HN—(CH2)2—[O—(CH2)]n—O—(CH2)2NH2, n=1-14} with in position C(2) symmetrically branched fatty acids of general formula IV, wherein n1=5-30, in the presence of condensation reagent, or from acid of general formula IV derived acylchloride of general formula V wherein n1=5-30, produces N-Boc-aminolipids of general formula VI, wherein n1=5-30 a X is polymethylene linker of the general formula II or X is polyethylene glycol linker of the general formula III.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: November 8, 2022
    Assignees: VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE, VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V. V. I., APIGENEX S.R.O.
    Inventors: Miroslav Ledvina, Roman Effenberg, Jaroslav Turanek, Elissa Bartheldyova, Ladislav Droz, Josef Masek, Frantisek Hubatka
  • AMINOOXYLIPIDS FOR THE CONSTRUCTION OF SELF-ASSEMBLING LIPOSOMAL SYSTEMS ENABLING THEIR SUBSEQUENT MODIFICATION BY BIOLOGICALLY FUNCTIONAL MOLECULES
    Publication number: 20210292275
    Abstract: New aminooxylipids of general formula I, wherein n1=5-30 and X is polymethylene linker of the general formula II where n2=2-10, or X is polyethylene glycol linker of the general formula III, wherein n3=1-14 are provided. A method of preparation of the aminooxylipids of general formula I characterized in that the acylation of N-tert-butoxycarbonyl-polymethylenediamine {(CH3)3C—O—(C?O)—HN—(CH2)n—NH2, n=2-13}, or N-tert-butoxycarbonyl-polyethyleglycoldiamine {(CH3)3C—O—(C?O)—HN—(CH2)2—[O—(CH2)]n—O—(CH2)2NH2, n=1-14} with in position C(2) symmetrically branched fatty acids of general formula IV, wherein n1=5-30, in the presence of condensation reagent, or from acid of general formula IV derived acylchloride of general formula V wherein n1=5-30, produces N-Boc-aminolipids of general formula VI, wherein n1=5-30 a X is polymethylene linker of the general formula II or X is polyethylene glycol linker of the general formula III.
    Type: Application
    Filed: November 2, 2017
    Publication date: September 23, 2021
    Applicants: VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE, VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V.V.I., APIGENEX S.R.O.
    Inventors: Mirolav LEDVINA, Roman EFFENBERG, Jaroslav TURANEK, Elissa BARTHELDYOVA, Ladislav DROZ, Josef MASEK, Frantisek HUBATKA