Abstract: A method is offered to predict and prevent the event of fracture hit (direct fluid communication) between a parent well and a child (active) well. The growth of a child well creates 3D stress field in the vicinity of a parent well. The growth of a child well is simulated using the geomechanic-transport model. A model of interaction between the child well and parent well is provided. The simulations for different job designs create a set of pressure scenario in the parent both for the cases with and without fracture hit (fracture hit catalogue). Comparison (matching) of actual pressure data in the parent and child well with the pre-calculated pressure scenarios indicate the risk of fracture development with a fracture hit, which means a stop in fracturing stimulation.

Abstract: The present invention provides a method of designing a modulator of a myosin, the method comprising molecular modeling of a compound such that the modeled compound interacts with at least three amino acid residues of said myosin, said residues being selected from (a) ranges K265-V268, V411-L441, N588-Q593, D614-T629, and V630-E646 of SEQ ID NO: 2, said myosin comprising or consisting of (i) the sequence of SEQ ID NO: 2; (ii) the sequence encoded by the sequence of SEQ ID NO: 1; (iii) a sequence being at least 40% identical to the sequence of SEQ ID NO: 2 or to the sequence encoded by the sequence of SEQ ID NO: 1; or (iv) a sequence encoded by a sequence being at least 40% identical to the sequence of SEQ ID NO: 1; wherein said sequence of (iii) or (iv) comprises said three amino acid residues, and wherein said residues comprise K265; or (b) ranges of any one of SEQ ID NOs: 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 7